Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Aggressive Periodontitis: Cytokine Profile in Gingival Crevicular Fluid, Preliminary Results

The aim of this study was to evaluate the effectiveness of the non-surgical periodontal treatment in reducing the gingival crevicular fluid (GCF) levels of IL-18 from inflamed periodontal sites. Fourteen patients with periodontal disease were included, being 9 patients with chronic periodontitis (mean age: 48.8 SD ± 7.4 years) and 5 patients with gingivitis (mean age: 43.6 SD ± 11.8). The patients were divided in the following groups: gingivitis sites from periodontitis patients (sites GP), periodontitis sites from periodontitis patients (sites PP), and gingivitis sites from gingivitis patients (sites GG). Probing pocket depth (PPD), probing attachment level (AL), plaque index (PI) and gingival index (GI) were recorded, and gingival fluid samples were collected. The subjects received non-surgical treatment and were re-evaluated 30 days after treatment (day 30 AT). There was a significant reduction in PI in GG (1.0 ± 0.4 to 0.5 ± 0.2), GP (1.2 ± 0.3 to 0.5 ± 0.3), and in PP (1.3 ± 0.4 to 0.7 ± 0.3) 30 AT. There was also a significant reduction in the GI in GG (1.3 ± 0.3 to 0.7 ± 0.4). PPD reduced significantly in GG (2.4 ± 0.6 to 1.9 ± 0.1), and PP (6.7 ± 1.1 to 5.2 ± 0.9) 30 AT. When all the samples were analyzed together, there was a significant reduction in IL-18 (12.9 ± 7.2 to 10.0 ± 3.1). This study showed that non-surgical treatment was effective in reducing GCF levels of IL-18 from inflamed periodontal sites.

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Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2020.101808 ◽

2020 ◽

Vol 31 ◽

pp. 101808

Author(s):

Eduardo Quintão Manhanini Souza ◽

Tiago Esgalha da Rocha ◽

Luan Felipe Toro ◽

Isabella Zacarin Guiati ◽

Edilson Ervolino ◽

...

Keyword(s):

Systematic Review ◽

Photodynamic Therapy ◽

Surgical Treatment ◽

Antibiotic Therapy ◽

Meta Analysis ◽

Antimicrobial Photodynamic Therapy ◽

Systemic Antibiotic ◽

Systemic Antibiotic Therapy ◽

Non Surgical Treatment

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PHOTODYNAMIC THERAPY AS AN EFFICIENT ADJUNCT TO NON SURGICAL TREATMENT OF PERIODONTITIS: A CASE SERIES

10.36106/gjra/0909580 ◽

2021 ◽

pp. 76-77

Author(s):

Nisha Jain ◽

Rudrax Jindal

Keyword(s):

Photodynamic Therapy ◽

Surgical Treatment ◽

Chronic Periodontitis ◽

Case Series ◽

Antimicrobial Photodynamic Therapy ◽

Pocket Depth ◽

Clinical Attachment Loss ◽

Bleeding On Probing ◽

Probing Depth ◽

Non Surgical Treatment

The aim of this case series was to assess the efcacy of antimicrobial photodynamic therapy in the treatment of chronic periodontitis. This case series included two subjects with Presence of pocket depth 6 mm or more with clinical attachment loss(CAL) and bleeding on probing (BOP) in minimum of 1 tooth in atleast two quadrants. After full mouth mechanical debridement (SRP), rst site received no further treatment, whereas, second site was subjected to photodynamic therapy. SRP+PDT group showed signicant improvement in (CAL) and reduction in probing depth as compared to SRP group. Therefore, it can be concluded that Photodynamic therapy has its own advantage as an adjunct to SRP in the non surgical treatment of chronic periodontitis,further research for which may be advocated

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