scholarly journals THE STUDY OF THE EFFECT OF POLYMER-ADENOSINE MOLECULAR COMPLEXES ON THE THERMAL BURN MODEL

Author(s):  
A.A. Ermolaeva ◽  
◽  
V.V. Ponomarenko ◽  
A.V. Novoselov ◽  
E.D. Semivelichenko ◽  
...  
2002 ◽  
Vol 4 ◽  
pp. 133-133
Author(s):  
D. Teyssier ◽  
P. Hennebelle ◽  
M. Pérault
Keyword(s):  

Author(s):  
Narendar D ◽  
Ettireddy S

The content of this investigation was to study the influence of β-cyclodextrin and hydroxy propyl-β-cyclodextrin complexation on enhancement of solubility and dissolution rate of isradipine. Based on preliminary phase solubility studies, solid complexes prepared by freeze drying method in 1:1 molar ratio were selected and characterized by DSC for confirmation of complex formation. Prepared solid dispersions were evaluated for drug content, solubility and in vitro dissolution. The physical stability of optimized formulation was studied at refrigerated and room temperature for 2 months. Solid state characterization of optimized complex performed by DSC and XRD studies.  Dissolution rate of isradipine was increased compared with pure drug and more with HP-β-CD inclusion complex than β-CD. DSC and XRD analyzes that drug was in amorphous form, when the drug was incorporated as isradipine β-CD and HP-β-CD inclusion complex. Stability studies resulted in low or no variations in the percentage of complexation efficiency suggesting good stability of molecular complexes. The results conclusively demonstrated that the enhancement of solubility and dissolution rate of isradipine by drug-cyclodextrin complexation was achieved.   


2015 ◽  
Vol 12 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Leonid A. Yakovishin ◽  
Vladimir I. Grishkovets ◽  
Elena N. Korzh

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Z. Q. Wang ◽  
K. Nithyanandan ◽  
A. Coillet ◽  
P. Tchofo-Dinda ◽  
Ph. Grelu

2021 ◽  
Author(s):  
Stanislav N. Melnikov ◽  
Igor Evstifeev ◽  
Stanislav A. Nikolaevskii ◽  
Ivan V. Ananyev ◽  
Evgenia Varaksina ◽  
...  

The systematical series of Zn-Ln trinuclear carboxylate molecular complexes with general formula [Zn2Ln(NO3)(phbz)6(L)2] (Ln = Eu, Gd, Tb; phbz is anion of 4-biphenylcarboxylic acid; L is pyridine, 2,3-lutidine or 2,2’-bipyridine)...


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