scholarly journals N-acetylcysteine fails to prevent renal dysfunction and oxidative stress after noniodine contrast media administration during percutaneous coronary interventions

2010 ◽  
Vol 120 (10) ◽  
pp. 383-389 ◽  
Author(s):  
Hakan Buyukhatipoglu ◽  
Yusuf Sezen ◽  
Ali Yildiz ◽  
Memduh Bas ◽  
Idris Kirhan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Contrast Media ◽  
Renal Dysfunction ◽  
Percutaneous Coronary Interventions ◽  
Coronary Interventions ◽  
Percutaneous Coronary ◽  
And Oxidative Stress ◽  
Contrast Media Administration

scholarly journals Trends in contrast-induced acute kidney injury rate after percutaneous coronary interventions in coronary artery disease

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
O Mironova ◽  
OA Sivakova ◽  
VV Fomin
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Media ◽  
Preventive Measures ◽  
Clinical Importance ◽  
Injury Rate ◽  
Kidney Injury ◽  
Percutaneous Coronary Interventions ◽  
Coronary Interventions ◽  
Percutaneous Coronary ◽  
Coronary Syndromes

Abstract Funding Acknowledgements Type of funding sources: None. Background. Contrast-induced acute kidney injury remains one of the dangerous complications of percutaneous coronary interventions, in spite of the evolution of contrast media and prevention strategies. Many researchers assume that this syndrome is not as frequent as it used to be and its clinical importance is overestimated. Purpose. The aim of the study was to assess the rates of contrast-induced acute kidney injury in a prospective study in patients with chronic coronary syndromes after percutaneous coronary interventions in 2012 and 2017 respectively. Methods. 1023 patients with chronic coronary syndromes and indications for the interventions with intra-arterial contrast media administration were included in the prospective open cohort study. 561 patients were enrolled in 2012 and 462 in 2017 respectively. The contrast media remained the same both in 2012 and 2017. Preventive measures included the administration of 0,9% saline 1 ml/kg/h intravenously and 0,5 kg/ml/h for the patients with heart failure before and after procedure. The primary endpoint was the development of contrast-induced acute kidney injury.  Results. The incidence of contrast-induced acute kidney injury decreased more than 3 times in 2017 than in 2012 (6% vs. 18,5%, 28 patients vs 104 patients respectively). The difference was statistically significant (p < 0,0001). The patients included in the study in 2017 were older, had higher body mass index and had more risk factors, than the ones enrolled in 2012. We organised several conferences for all the cardiologist involved in the treatment of patients undergoing percutaneous coronary intervention, as well as were printing materials describing the risk assessment and preventive measures that should be done in patients with chronic coronary syndromes before percutaneous coronary interventions (eg, stopping metformin and nephrotoxic drugs). Conclusion. The prevalence of contrast-induced acute kidney injury is decreasing not only due to the evolution of contrast media and preventive strategies, but also due to the higher level of education of all the doctors about the syndrome and its prognosis, as well as available preventive measures and treatment options.

Serious renal dysfunction after percutaneous coronary interventions can be predicted

2008 ◽  
Vol 155 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Jeremiah R. Brown ◽  
James T. DeVries ◽  
Winthrop D. Piper ◽  
John F. Robb ◽  
Michael J. Hearne ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Percutaneous Coronary Interventions ◽  
Coronary Interventions ◽  
Percutaneous Coronary

scholarly journals Topical Issues of Rational Use of Iodine-Containing Contrast Agents in X-Ray Diagnostics

2021 ◽  
Vol 102 (4) ◽  
pp. 255-262
Author(s):  
N. L. Shimanovskiy
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agents ◽  
Injection Pressure ◽  
Solution Viscosity ◽  
Percutaneous Coronary Interventions ◽  
Rational Use ◽  
X Ray ◽  
Coronary Interventions ◽  
Percutaneous Coronary

The possibilities of rational use of iodine radiopaque agents in computed tomography and percutaneous coronary interventions are considered, taking into account the route, method of their administration and the viscosity of their solutions. When fixing the rate of iodine administration and the temperature of the injected solution, the required injection pressure of the contrast media is determined by the solution viscosity.

scholarly journals Oxidant and antioxidant status in patients undergoing percutaneous coronary interventions

2017 ◽  
Vol 8 (2) ◽  
pp. 29-33
Author(s):  
Vonteru Lakshmi Asha Latha ◽  
Musturu Manohar Suchitra ◽  
Aparna Rajeswara Rao Bitla ◽  
Pemmaraju Venkata Lakshmi Narasimha Srinivasa Rao ◽  
Durgaprasad Rajasekhar
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Time Course ◽  
Myocardial Damage ◽  
Percutaneous Coronary Interventions ◽  
Mortality And Morbidity ◽  
Antioxidative Status ◽  
Coronary Interventions ◽  
Reducing Ability ◽  
Percutaneous Coronary

Background: Coronary artery disease (CAD) is the major disease leading to cause mortality and morbidity. The imbalance between the generation of reactive oxygen species (ROS) and the intrinsic antioxidant defense system leading to the oxidative stress, has been implicated in the pathogenesis of the cardiovascular disease. The formed free radicals and subsequent lipid peroxidation may be responsible for myocardial damage in patients undergoing percutaneous coronary interventions. Therefore, the understanding of the pathophysiological role of ROS generated during or after coronary interventions is essential to improve the success rate of these procedures.Aims and Objective: The aim of this study was to evaluate the time course changes of oxidant and antioxidant status, in patients undergoing percutaneous coronary interventions (PCI).Materials and Methods: The study included 120 consecutive patients (117 males, 3 females; mean age 58.4 years) who underwent elective PCI. Coronary angiography and coronary angioplasty were performed according to the standard protocols. Blood samples were taken just before (0hrs) and at 4 hrs and 24 hrs after coronary interventions to determine the oxidative status i.e. plasma malondialdehyde (MDA) and for antioxidative status, erythrocyte glutathione peroxidase (GPx), erythrocyte glutathione (GSH) and plasma ferric reducing ability of plasma (FRAP).Results: There was significant increase in MDA levels (1.87±0.34, 1.90±0.46, p=0.000), at 4hrs and 24hrs after coronary interventions when compared to baseline levels. After coronary interventions, the GPx activity (12.96±8.37, 12.3±7.76, p=0.000) and FRAP levels (0.73±0.21, 0.70±0.23, p=0.001 respectively) were found to be increased significantly at 4hrs and 24hrs. However, the glutathione levels (2.40±0.57, 2.47±0.53, p=0.040) were decreased at 4hrs and 24hrs after coronary interventions.Conclusion: Our study demonstrates that presence of oxidative stress in coronary interventions. The increase in antioxidants in the present study may be due to paradoxical increase in oxidant levels in patients undergoing coronary interventions.Asian Journal of Medical Sciences Vol.8(2) 2017 29-33

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