DIFFERENCES IN LED VALUES IN DENGUE FEVER PATIENTS WITH HEMOCONCENTRATION AND NOT HEMOCONCENTRATION

Background: Patients with dengue fever with hemoconcentration will experience plasma tearing (loss of plasma protein) which will affect the value of the Erythrocyte Sedimentation Rate (LED). Plasma proteins that play a role in influencing the value of the Sedimentation Rate (LED) are fibrinogen and globulins. An erythrocyte sedimentation (LED) examination measures the degree of erythrocyte deposition in a blood sample over a period of time. LEDs are sensitive but not specific tests. Purpose: To determine the difference in LED values of DHF patients with hemoconcentration and not hemoconcentration. Methods: Observational analytic, 30 samples with criteria for dengue fever patients with hemoconcentration and not hemoconcentration were examined at the Clinical Pathology Laboratory of Haji Hospital Surabaya in March - April 2019. The study used an independent t test with SPSS 16.0 program to determine whether there were differences in LED values in dengue fever patients with hemoconcentration and not hemoconsetration. Results: The results of the Independent t test showed that there were significant differences between the results of the erythrocyte sedimentation rate in patients with dengue fever with hemoconcentration and not hemoconsetration with Sig. (2-failed) of 0.00 (p <0.005). Conclusion: There are significant differences in sediment rate results with the Westergreen blood method in patients with dengue fever who experience hemoconcentration and who do not experience hemoconcentration.

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The comparison of erythrocyte sedimentation rate (ESR) modify Westergren Caretium Xc-A30 and Westergren Manual in Clinical Pathology Laboratory, Sanglah General Hospital, Denpasar, Bali

Bali Medical Journal ◽

10.15562/bmj.v8i2.1401 ◽

2019 ◽

Vol 8 (2) ◽

pp. 487

Author(s):

Made Minarti Witarini Dewi ◽

Sianny Herawati ◽

Ni Kadek Mulyantari ◽

I Putu Yuda Prabawa

Keyword(s):

Erythrocyte Sedimentation Rate ◽

General Hospital ◽

Sedimentation Rate ◽

Clinical Pathology ◽

Pathology Laboratory ◽

Erythrocyte Sedimentation

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The plasma proteins in cases with high erythrocyte sedimentation rate

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1946.tb19246.x ◽

2009 ◽

Vol 123 (S170) ◽

pp. 280-306

Author(s):

HAQVIN MALMROS ◽

GUNNAR BLIX

Keyword(s):

Erythrocyte Sedimentation Rate ◽

Sedimentation Rate ◽

Plasma Proteins ◽

Erythrocyte Sedimentation ◽

High Erythrocyte Sedimentation Rate

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Microfluidic-Based Biosensor for Blood Viscosity and Erythrocyte Sedimentation Rate Using Disposable Fluid Delivery System

Micromachines ◽

10.3390/mi11020215 ◽

2020 ◽

Vol 11 (2) ◽

pp. 215

Author(s):

Yang Jun Kang

Keyword(s):

Blood Sample ◽

Erythrocyte Sedimentation Rate ◽

Flow Rate ◽

Sedimentation Rate ◽

Blood Viscosity ◽

Blood Samples ◽

Image Intensity ◽

Fluid Delivery ◽

Erythrocyte Sedimentation ◽

Over Time

To quantify the variation of red blood cells (RBCs) or plasma proteins in blood samples effectively, it is necessary to measure blood viscosity and erythrocyte sedimentation rate (ESR) simultaneously. Conventional microfluidic measurement methods require two syringe pumps to control flow rates of both fluids. In this study, instead of two syringe pumps, two air-compressed syringes (ACSs) are newly adopted for delivering blood samples and reference fluid into a T-shaped microfluidic channel. Under fluid delivery with two ACS, the flow rate of each fluid is not specified over time. To obtain velocity fields of reference fluid consistently, RBCs suspended in 40% glycerin solution (hematocrit = 7%) as the reference fluid is newly selected for avoiding RBCs sedimentation in ACS. A calibration curve is obtained by evaluating the relationship between averaged velocity obtained with micro-particle image velocimetry (μPIV) and flow rate of a syringe pump with respect to blood samples and reference fluid. By installing the ACSs horizontally, ESR is obtained by monitoring the image intensity of the blood sample. The averaged velocities of the blood sample and reference fluid (<UB>, <UR>) and the interfacial location in both fluids (αB) are obtained with μPIV and digital image processing, respectively. Blood viscosity is then measured by using a parallel co-flowing method with a correction factor. The ESR is quantified as two indices (tESR, IESR) from image intensity of blood sample (<IB>) over time. As a demonstration, the proposed method is employed to quantify contributions of hematocrit (Hct = 30%, 40%, and 50%), base solution (1× phosphate-buffered saline [PBS], plasma, and dextran solution), and hardened RBCs to blood viscosity and ESR, respectively. Experimental Results of the present method were comparable with those of the previous method. In conclusion, the proposed method has the ability to measure blood viscosity and ESR consistently, under fluid delivery of two ACSs.

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