scholarly journals Effect of hydrogen sulfide on the contractile activity of smooth muscle cells from the rat aorta

2010 ◽  
Vol 9 (6) ◽  
pp. 12-17
Author(s):  
M. B. Baskakov ◽  
S. V. Gusakova ◽  
A. S. Zheludeva ◽  
L. V. Smagly ◽  
I. V. Kovalyov ◽  
...  

In preparations of rat aorta, used as a model of muscular type arteries, the method mehanografii studied the effect of hydrogen sulfide on the reduction of isolated of vascular smooth muscle. Found that hydrogen sulfide in concentrations 1—50 mmol increases the mechanical stress of smooth muscle in high-K + medium. At higher concentrations (300—1 000 mmol) H2S leads to lower amplitude giperkalievoy contraction in high-K + medium. Reduction of smooth muscle cells caused by phenylephrine inhibited the action of hydrogen sulfide in the whole range of concentrations. The causes of differences in data obtained with the results of studies in other laboratories, and possible mechanisms of action of hydrogen sulfide on the contractile activity of vascular smooth muscle.

2009 ◽  
Vol 8 (4) ◽  
pp. 41-46
Author(s):  
I. V. Kovalyev ◽  
S. V. Gusakova ◽  
O. S. Melnik ◽  
M. B. Baskakov ◽  
L. V. Kapilevich ◽  
...  

The influence of of hydrogen peroxide on the contractile reactions of smooth muscle cells caused by hyperpotassium solution end phenylephrine in modulation a potassium conductance the membrane and the state of cytoskeleton elements has been investigated by the mechanographical method. It has multidirectional influence of hydrogen peroxide in the reduction of smooth muscles of rat aorta with the membrane depolarization hyperpotassium solution and action phenylephrine: phenylephrine decline in value and increase strength hyperpotassium contractures. We show that the cytoskeleton components involved in the mechanisms of action of hydrogen peroxide in the contractile reactions of smooth muscles of rat aorta caused by phenylephrine.


2010 ◽  
Vol 12 (9) ◽  
pp. 1093-1100 ◽  
Author(s):  
Tuanjie Chang ◽  
Ashley Untereiner ◽  
Jianghai Liu ◽  
Lingyun Wu

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