This chapter presents George Boole's lecture on the discoveries of Sir Isaac Newton. The first subject of importance that engaged Newton's attention was the phenomena of prismatic colors. The results of his inquiries were communicated to the Royal Society in the year 1675, and afterwards published with most important additions in 1704. The production was entitled “Optics; or, a Treatise on the Reflections, Refractions, Inflections, and Colours of Light.” It is considered one of the most elaborate and original of his works, and carries on every page the traces of a powerful and comprehensive mind. Newton also discovered universal gravitation, which was announced to the world in 1687 through the publication of the “Principia, or Mathematical Principles of Natural Philosophy.” The object of the “Principia” is twofold: to demonstrate the law of planetary influence, and to apply that law to the purposes of calculation.