Post-Transplant Lymphoproliferative Diseases in an Elderly Population Who Underwent Cardiac Transplantation: Role of Physical Activity Rehabilitation Program

The incidence of post transplantation lymphoproliferative disorders (PTLDs) and other neoplasms in organ transplant patients is higher than in the non-transplanted population. This event is more frequent in older subjects, due, at least in part, to the immune dysfunction induced by immunosuppressants administered to prevent rejection. Alterations of the immune system mechanisms of protection against carcinogenesis appear to be the key role in the in the pathogenesis of these neoplasms. The data of our study on the incidence of neoplasms occurred during a long-term follow-up in an elderly population after they underwent cardiac transplantation. This study gives, also evidence of the favorable effect of physical activity programs on cardiorespiratory and psychomotor function.

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The nephrology crystal ball: the medium-term future

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfz199 ◽

2019 ◽

Author(s):

Carmine Zoccali ◽

Peter J Blankestijn ◽

Annette Bruchfeld ◽

Giovambattista Capasso ◽

Danilo Fliser ◽

...

Keyword(s):

Kidney Disease ◽

Ad Hoc ◽

Organ Transplant ◽

Medium Term ◽

Transplant Patients ◽

Clinical Ward ◽

Long Term Follow Up ◽

Kidney Transplant Patients ◽

The Impact

Abstract In January 2019, the ERA-EDTA surveyed nephrologists with questions on kidney care and kidney research designed to explore comprehension of the impact of alterations to organization of renal care and of advancements in technology and knowledge of kidney disease. Eight hundred and twenty-five ERA-EDTA members, ∼13% of the whole ERA-EDTA membership, replied to an ad hoc questionnaire. More than half of the respondents argued that kidney centres will be increasingly owned by large dialysis providers, nearly a quarter of respondents felt that many medical aspects of dialysis will be increasingly overseen by non-nephrologists and a quarter (24%) also believed that the care and long-term follow-up of kidney transplant patients will be increasingly under the responsibility of transplant physicians caring for patients with any organ transplant. Nearly half of the participants (45%, n = 367) use fully electronic clinical files integrating the clinical ward, the outpatient clinics, the haemodialysis and peritoneal dialysis units, as well as transplantation. Smartphone-based self-management programmes for the care of chronic kidney disease (CKD) patients are scarcely applied (only 11% of surveyed nephrologists), but a substantial proportion of respondents (74%) are eager to know more about the potential usefulness of these apps. Finally, European nephrologists expressed a cautious optimism about the application of omic sciences to nephrology and on wearable and implantable kidneys, but their expectations for the medium term are limited.

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Bariatric surgery in solid organ transplant patients: Long-term follow-up results of outcome, safety, and effect on immunosuppression

American Journal of Transplantation ◽

10.1111/ajt.14739 ◽

2018 ◽

Vol 18 (11) ◽

pp. 2772-2780 ◽

Cited By ~ 22

Author(s):

Renana Yemini ◽

Eviatar Nesher ◽

Janos Winkler ◽

Idan Carmeli ◽

Carmil Azran ◽

...

Keyword(s):

Bariatric Surgery ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Patients ◽

Long Term Follow Up

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Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

10.20944/preprints201912.0379.v1 ◽

2019 ◽

Author(s):

Antonello Sica ◽

Maria Luisa de Rimini ◽

Beniamino Casale ◽

Caterina Sagnelli ◽

Alessandro Spada ◽

...

Keyword(s):

Inflammatory Diseases ◽

Organ Transplant ◽

The Elderly ◽

Rehabilitation Program ◽

Favorable Effect ◽

Sports Activity ◽

Transplant Patients ◽

Positron Emission ◽

Diagnostic Role ◽

Conventional Ct

The incidence of cancer in organ transplant patients is higher than in the non-transplanted population. The incidence increases with increasing age. The use of Fludeoxyglucose positron emission tomography/CT (PET/CT) is sensitive and specific to detect PTLD LD compared with conventional CT imaging. We analyzed the medical data of 127 patients aged over 60 years, who underwent heart transplantation in the above period, who have been practicing early CT-PET for diagnostic purposes between February 2007 and October 2018. Of 127 consecutive patients who underwent CT-PET, SUVs up than 4, were found in 84 patients of which 20 were affected by PTLDs, seven patients were affected by chronic non neoplastic inflammatory diseases, the remainder were affected by other neoplasms. The favorable effect of physical activity programs on cardiorespiratory and psychomotor function occur in all patients. In conclusion, CT-PET at the first doubts about the possibility of the development of neoplasms has allowed a diagnosis and then a treatment more quickly. Education in behavioral norms that improve the patient's quality of life is necessary.

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