FABRICATION AND CHARACTERIZATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM BASED IN SUPERPOROUS HYDROGEL COMPOSITE

2017 ◽  
pp. 575-600
Author(s):  
Aakash Sahu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrogel Composite ◽  
Fabrication And Characterization ◽  
Superporous Hydrogel

scholarly journals Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Hitesh Chavda ◽  
Ishan Modhia ◽  
Anant Mehta ◽  
Rupal Patel ◽  
Chhagan Patel
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Release Kinetics ◽  
Hydrogel Composite ◽  
Intestinal Delivery ◽  
Superporous Hydrogel

Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 32full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content,in vitrodrug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.

Facile fabrication and characterization of a novel oral pH-sensitive drug delivery system based on CMC hydrogel and HNT-AT nanohybrid

2018 ◽  
Vol 107 ◽  
pp. 2436-2449 ◽  
Author(s):  
Seyed Jamal Hossieni-Aghdam ◽  
Behrouz Foroughi-Nia ◽  
Zhila Zare-Akbari ◽  
Solmaz Mojarad-Jabali ◽  
Hamidreza motasadizadeh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Facile Fabrication ◽  
Fabrication And Characterization

The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system

2016 ◽  
Vol 52 (6) ◽  
pp. 3133-3145 ◽  
Author(s):  
Madichaba P. Chelopo ◽  
Lonji Kalombo ◽  
James Wesley-Smith ◽  
Anne Grobler ◽  
Rose Hayeshi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fabrication And Characterization ◽  
Plga Nanoparticle
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