Abstract
Background: Many factors cause hospital mortality (HM) after liver transplantation (LT). Methods: We performed a retrospective research in single center from October 2005 to June 2019. The study included 466 living donor LT patients. They were divided into a no-HM group (n=436, 93.56%) and an HM group (n=30, 6.44%). Logistic regression analysis of factors affecting clinical features and surgical volume of HM. We regrouped patients into met the surgical volume periods based cutoffs of LTs, and analyze the clinical features.Results: Multivariate analysis revealed that donor age (OR= 1.049, 95% CI: 1.011– 1.090, p=0.013), blood loss (OR=1.000, 95% CI: 1.000–1.000, p=0.004), and annual surgical volumes being < 30 LTs (OR=2.521, 95% CI: 1.004–6.332, p=0.049) were significant risk factors. A comparison of years based on surgical volume found that when the annual surgical volumes were at least 30 there was significantly higher recipient age (p=0.022), donor age (p=0.024), and ABO-incompatible operations (p<0.001) and also significantly blood loss (p<0.001), operative time (p<0.001), intensive care unit days (p<0.001), length of stay (p=0.013), re-operative (p<0.001), and HM (p=0.029) compared to when the annual surgical volumes were less than 30. Conclusions: Donor age, blood loss and an annual surgical volume < 30 LTs were significant pre- and peri-operative risk factors. Hospital mortality and annual surgical volume were associated with statistically significant differences; surgical volume may impact quality of care and transplant outcomes.
In-hospital mortality of liver transplantation and risk factors: a single-center experience
