scholarly journals Generating comprehensive comparative evidence on various interventions for penile rehabilitation in patients with erectile dysfunction after radical prostatectomy: a systematic review and network meta-analysis

2021 ◽  
Vol 10 (1) ◽  
pp. 109-124
Author(s):  
Dechao Feng ◽  
Shengzhuo Liu ◽  
Yubo Yang ◽  
Yunjin Bai ◽  
Dengxiong Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Meta Analysis ◽  
Penile Rehabilitation

scholarly journals Penile Rehabilitation and Treatment Options for Erectile Dysfunction Following Radical Prostatectomy and Radiotherapy: A Systematic Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Melianthe Nicolai ◽  
Ahmet Urkmez ◽  
Selcuk Sarikaya ◽  
Mikkel Fode ◽  
Marco Falcone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Animal Studies ◽  
Structural Changes ◽  
Treatment Options ◽  
Nerve Sparing ◽  
Phosphodiesterase Type 5 Inhibitors ◽  
Pelvic Floor Training ◽  
Penile Rehabilitation

After radical prostatectomy (RP) or radiotherapy (RT) for prostate cancer, erectile dysfunction (ED) is the main complication next to urinary incontinence, affecting quality of life. The pathophysiology of ED after these treatments is believed to include neuropraxia causing reduced oxygenation and structural changes of the tissue in the corpora cavernosa. Next to the option of sparing the nerves during RP, research has been focusing on methods for penile rehabilitation after RP and RT, since it occurs often, even after nerve-sparing techniques were used. In animal studies, the use of phosphodiesterase type 5 inhibitors (PDE5i) after cavernous nerve damage is supported, but results in human studies are contradictory. Non-medical treatment options such as vacuum device therapy, hyperbaric oxygen therapy, yoga, aerobic, or pelvic floor training may be helpful, but evidence is scarce. Clear guidelines for penile rehabilitation are not yet available. However, care and support for ED after RP and RT is highly demanded by a large group of patients, so measures have to be taken even though the evidence is not strong yet. In this systematic review, an overview of the literature for penile rehabilitation and treatment options for ED after RP and RT is provided, using only randomized controlled trials (RCT).

scholarly journals MP85-08 PENILE REHABILITATION FOR POST-PROSTATECTOMY ERECTILE DYSFUNCTION: A COCHRANE SYSTEMATIC REVIEW AND META-ANALYSIS

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Yiannis Philippou ◽  
Jae Hung Jung ◽  
Martin Steggall ◽  
Caitlin Bakker ◽  
Philipp Dahm
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Meta Analysis ◽  
Cochrane Systematic Review ◽  
Penile Rehabilitation

scholarly journals Erectile dysfunction and penile rehabilitation after pelvic fracture: a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e045117
Author(s):  
Florian A Schmid ◽  
Ulrike Held ◽  
Daniel Eberli ◽  
Hans-Christoph Pape ◽  
Sascha Halvachizadeh
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Literature Search ◽  
Meta Analysis ◽  
P Value ◽  
Systematic Literature Search ◽  
Rehabilitation Therapy ◽  
Increased Risk ◽  
Before And After ◽  
Penile Rehabilitation

ObjectiveTo investigate the rate of erectile dysfunction (ED) after pelvic ring fracture (PRF).DesignSystematic review and meta-analysis.MethodsA systematic literature search of the Cochrane, EMBASE, MEDLINE, Scopus and Web of Science Library databases was conducted in January 2020. Included were original studies performed on humans assessing ED after PRF according to the 5-item International Index of Erectile Function (IIEF-5) questionnaire and fracture classification following Young and Burgess, Tile or Arbeitsgemeinschaft für Osteosynthesefragen/Orthopedic Trauma Association. Furthermore, interventional cohort studies assessing the effect of penile rehabilitation therapy with phosphodiesterase-5-inhibitors (PDE-5-I) on IIEF-5 scores compared before and after treatment were included. Results were presented as forest plots of proportions of patients with ED after PRF or mean changes on IIEF-5 questionnaires before and after penile rehabilitation. Studies not included in the quantitative analysis were narratively summarised. Risk of bias assessment was conducted using the revised tool for the Quality Assessment on Diagnostic Accuracy Studies.ResultsThe systematic literature search retrieved 617 articles. Seven articles were included in the qualitative analysis and the meta-analysis. Pooled proportions revealed 37% of patients with ED after suffering any form of PRF (result on probability scale pr=0.37, 95% CI: 0.26 to 0.50). Patients after 3 months of penile rehabilitation therapy reported a higher IIEF-5 score than before (change score=6.5 points, 95% CI: 2.54 to 10.46, p value=0.0013).ConclusionDespite some heterogeneity and limited high-quality research, this study concludes that patients suffering from any type of PRF have an increased risk of developing ED. Oral intake of PDE-5-I for the purpose of penile rehabilitation therapy increases IIEF-5 scores and may relevantly influence quality-of-life in these patients.PROSPERO registration numberCRD42020169699.

Management of erectile dysfunction following robot-assisted radical prostatectomy: a systematic review

2020 ◽  
Vol 72 (5) ◽  
Author(s):  
Michele Marchioni ◽  
Piergustavo De Francesco ◽  
Roberto Castellucci ◽  
Rocco Papalia ◽  
Selçuk Sarikaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Robot Assisted

scholarly journals Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Irham Arif Rahman ◽  
Nur Rasyid ◽  
Ponco Birowo ◽  
Widi Atmoko
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Kidney Transplantation ◽  
Renal Transplantation ◽  
End Stage Renal Disease ◽  
Erectile Function ◽  
Meta Analysis ◽  
Post Transplantation ◽  
Stage Renal Disease ◽  
End Stage

AbstractErectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function.

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