Smartphone Interventions Effect in Pediatric Subjects on the Day of Surgery: A Meta-Analysis

Background: A meta-analysis was performed to evaluate the effect of smartphone interventions on the anxiety of the pediatric subjects at induction on the day of surgery compared to oral midazolam or standard care as control.Methods: A systematic literature search up to June 2021 was performed and nine studies selected 785 pediatric subjects on the day of surgery at the start of the study; 390 of them were using smartphone interventions, 192 were control, and 203 were using oral midazolam. They were reporting relationships between the effects of smartphone interventions on the anxiety of the pediatric subjects at induction on the day of surgery compared to oral midazolam or control. The mean difference (MD) with its 95% CIs was calculated to assess the effect of smartphone interventions on the anxiety of the pediatric subjects at induction on the day of surgery compared to oral midazolam or control using the continuous method with a fixed or a random-effects model.Results: Smartphone interventions in pediatric subjects were significantly related to lower anxiety at induction on the day of surgery (MD, −19.74; 95% CI, −29.87 to −9.61, p < 0.001) compared to control and significantly related to lower anxiety at induction on the day of surgery (MD, −7.81; 95% CI, −14.49 to −1.14, p = 0.02) compared to oral midazolam.Conclusion: Smartphone interventions in pediatric subjects on the day of surgery may have lower anxiety at induction compared to control and oral midazolam. Further studies are needed to confirm these findings.

Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review

Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited. Objectives: To explore the pharmacological profile of specified compounds against COVID-19 Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review. Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.

P-Curve analysis of autonomous and controlling motivation priming effects supports their evidential value

Extant literature consistently demonstrates the level of self-determination individuals experience or demonstrate during an activity can be primed. However, considering most of this literature comes from a period wherein p-hacking was prevalent (pre-2015), it may be that these effects reflect false positives. The aim of the present study was to investigate whether published literature showing autonomous and controlling motivation priming effects contain evidential value or not. A systematic literature search was conducted to identify relevant priming research, while set rules determined which effects from each study would be used in p-curve analysis. Two p-curves including 33 effects each were constructed. P-curve analyses, even after excluding surprising effects (e.g., effects large in magnitude), demonstrated that literature showing autonomous and controlling motivation priming effects contained evidential value. The present findings support prior literature suggesting the effects of autonomous and controlling motivation primes exist at the population level. They also reduce (but do not eliminate) concerns from broader psychology that p-hacking may underlie reported effects.

Physical comorbidity and use of healthcare services in people with schizophrenia: protocol for a systematic review

IntroductionPeople with schizophrenia die about 15–20 years earlier than the general population. A constellation of factors contributes to this gap in life expectancy: side effects of psychotropic drugs, unhealthy lifestyles (inactivity, unhealthy diet) and inequality in the provision of healthcare services. This is a topic of main importance, which requires constant update and synthesis of the literature. The aim of this review is to explore the evidence of physical comorbidity and use of healthcare services in people with schizophrenia.Methods and analysisWe will conduct a systematic literature search in the databases PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO and Cochrane Library, Proquest Health Research Premium Collection, in order to identify studies that answer to our research question: Are patients with schizophrenia different from the non-psychiatric population in terms of physical comorbidity and use of healthcare services? Two authors will independently review the studies and extract the data.Ethics and disseminationThis study does not include human or animal subjects. Thus, ethics considerations are not applicable. Dissemination plans include publications in peer-reviewed journals and discussion of results in psychiatric congresses.PROSPERO registration numberCRD42020139972.

How effective are devices in the management of Onychomycosis? A protocol for a systematic review

Review question / Objective: To compile evidence and determine the utility of various device-based treatments for the treatment of onychomycosis, and improve the appearance of afflicted toenails. Condition being studied: Toenail onychomycosis, also known as tinea unguium. Information sources: A systematic literature search will be conducted in Scopus, MEDLINE and PubMed. The bibliographies of relevant articles will also be searched to ensure a comprehensive review is presented. Clinical trial registries (such as clinicaltrials.gov) will also be searched for complete, or incomplete trials.

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis

The unprecedented successes of immunotherapies (IOs) including immune checkpoint blockers (ICBs) and adoptive T-cell therapy (ACT) in patients with late-stage cancer provide proof-of-principle evidence that harnessing the immune system, in particular T cells, can be an effective approach to eradicate cancer. This instills strong interests in understanding the immunomodulatory effects of radiotherapy (RT), an area that was actually investigated more than a century ago but had been largely ignored for many decades. With the “newly” discovered immunogenic responses from RT, numerous endeavors have been undertaken to combine RT with IOs, in order to bolster anti-tumor immunity. However, the underlying mechanisms are not well defined, which is a subject of much investigation. We therefore conducted a systematic literature search on the molecular underpinnings of RT-induced immunomodulation and IOs, which identified the IFN–JAK–STAT pathway as a major regulator. Our further analysis of relevant studies revealed that the signaling strength and duration of this pathway in response to RT and IOs may determine eventual immunological outcomes. We propose that strategic targeting of this axis can boost the immunostimulatory effects of RT and radiosensitizing effects of IOs, thereby promoting the efficacy of combination therapy of RT and IOs.

Ocean acidification and bivalve byssus: explaining variable responses using meta-analysis

1. Many bivalve molluscs settle and attach to surfaces using adhesive byssal threads – proteinaceous fibers that together form a network known as the byssus. Since these bivalves rely on byssus for survival, strong byssal attachment promotes a myriad of broad ecological services, including water filtration, nutrient extraction, sediment stabilization, and enhancing biodiversity through habitat creation.2. Numerous studies have documented weakened byssal attachment strength under ocean acidification (OA); however, a comparable number report no effect, even within the same species. Consequently, whether elevated CO2 levels expected under near-future OA will affect byssal attachment strength in nature remains hotly contested.3. We used a systematic literature search and meta-analysis to explore factors that could potentially explain observed effect size variation in byssal attachment strength following OA exposure. 4. A systematic literature search uncovered 20 studies experimentally testing the impact of OA on byssal attachment strength (or some proxy thereof). Meta-analysis revealed that body size (mean shell length) was the strongest predictor of effect size variation, with no significant effect of climate, species, year, study temperature, study location, exposure time, food amount, and pH offset. Functionally, a negative linear relationship was observed between body size and effect size.5. Our finding that the byssal strength of larger bivalves is more susceptible to negative OA effects runs counter to prevailing wisdom that larger, older animals of a given species are more robust to OA than earlier life history stages. 6. This highlights that body size and age may be important factors that determine OA sensitivity in adult calcifiers. In addition to body size, a critical review of each study revealed commonly neglected factors that could influence byssal thread attachment strength which we highlight to provide suggestions for future research in this area.

Protocol for the development of a core outcome set for studies of pregnant women with pre-existing multimorbidity

IntroductionIncreasingly more pregnant women are living with pre-existing multimorbidity (≥two long-term physical or mental health conditions). This may adversely affect maternal and offspring outcomes. This study aims to develop a core outcome set (COS) for maternal and offspring outcomes in pregnant women with pre-existing multimorbidity. It is intended for use in observational and interventional studies in all pregnancy settings.Methods and analysisWe propose a four stage study design: (1) systematic literature search, (2) focus groups, (3) Delphi surveys and (4) consensus group meeting. The study will be conducted from June 2021 to August 2022. First, an initial list of outcomes will be identified through a systematic literature search of reported outcomes in studies of pregnant women with multimorbidity. We will search the Cochrane library, Medline, EMBASE and CINAHL. This will be supplemented with relevant outcomes from published COS for pregnancies and childbirth in general, and multimorbidity. Second, focus groups will be conducted among (1) women with lived experience of managing pre-existing multimorbidity in pregnancy (and/or their partners) and (2) their healthcare/social care professionals to identify outcomes important to them. Third, these initial lists of outcomes will be prioritised through a three-round online Delphi survey using predefined score criteria for consensus. Participants will be invited to suggest additional outcomes that were not included in the initial list. Finally, a consensus meeting using the nominal group technique will be held to agree on the final COS. The stakeholders will include (1) women (and/or their partners) with lived experience of managing multimorbidity in pregnancy, (2) healthcare/social care professionals involved in their care and (3) researchers in this field.Ethics and disseminationThis study has been approved by the University of Birmingham’s ethical review committee. The final COS will be disseminated through peer-reviewed publication and conferences and to all stakeholders.