Analysis of surgical treatment and prognostic factors for hepatocellular carcinoma with portal vein tumor thrombus

2017 ◽  
Vol 6 (1) ◽  
pp. 247-253
Author(s):  
Jingyu Cao ◽  
Zusen Wang ◽  
Shengkun Wu ◽  
Yao Yu ◽  
Chengzhan Zhu ◽  
...  
2021 ◽  
Vol 8 ◽  
Author(s):  
Shun Liu ◽  
Kai-Cai Liu ◽  
Wei-Fu Lv ◽  
Dong Lu ◽  
Xian-Hai Zhu ◽  
...  

Objective: Apatinib is a inhibitor of vascular endothelial growth factor receptor-2. To explore the efficacy and prognostic factors of transarterial chemoembolization (TACE) combined with apatinib in the treatment of Barcelona Clinic Liver Cancer stage C (BCLC C) hepatocellular carcinoma (HCC).Methods: Clinical data of 146 HCC patients with BCLC stage C admitted to our hospital were collected and analyzed retrospectively, of which 76 cases were treated with TACE combined with apatinib (TACE-apatinib) and 70 with TACE alone. The tumor response, survival time, and adverse events were compared between the two groups, and the factors affecting the prognosis were analyzed.Results: The objective response rate (ORR) and disease control rate (DCR) in the TACE-apatinib group were higher than in the TACE-alone group (ORR: 42.10 vs. 25.71%, P = 0.03; DCR: 84.21 vs. 55.71%, P = 0.001). The median time to progression (TTP) and overall survival (OS) in the TACE-apatinib group were longer than in the TACE-alone group (TTP: 5.5 vs. 3.7 months, P = 0.02; OS: 10.0 vs. 6.2 months, P = 0.01). Univariate and multivariate Cox regression analysis showed that tumor size, Child-Pugh class, and the presence of the portal vein tumor thrombus affect the prognosis of patients. Subgroup analysis revealed that TACE-apatinib therapy resulted in a higher OS in patients with tumor size <10 cm, without portal vein tumor thrombus, and with Child-Pugh class A (P < 0.05). The likelihood of adverse events (hand-foot syndrome, hypertension, oral ulcer) was significantly higher in the increased in the TACE-apatinib group than in the TACE alone group (P < 0.05).Conclusion: TACE-apatinib is an effective and safe method for the treatment of BCLC stage C HCC. Tumor size, Child-Pugh class, and portal vein tumor thrombus affect survival time in HCC patients with BCLC stage C.


2018 ◽  
Vol 24 (40) ◽  
pp. 4527-4535 ◽  
Author(s):  
Shu-You Peng ◽  
Xu-An Wang ◽  
Cong-Yun Huang ◽  
Jiang-Tao Li ◽  
De-Fei Hong ◽  
...  

2010 ◽  
Vol 17 (8) ◽  
pp. 2073-2080 ◽  
Author(s):  
Jie Shi ◽  
Eric C. H. Lai ◽  
Nan Li ◽  
Wei-Xing Guo ◽  
Jie Xue ◽  
...  

2009 ◽  
Vol 13 (6) ◽  
pp. 1078-1083 ◽  
Author(s):  
Kazuhiro Kondo ◽  
Kazuo Chijiiwa ◽  
Masahiro Kai ◽  
Kazuhiro Otani ◽  
Koki Nagaike ◽  
...  

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