The Role of Nitric Oxide Synthase and Heme Oxygenase in the Protective Effect of Hypothermia in Ischemia-Reperfusion Injury

2009 ◽  
Vol 91 (11) ◽  
pp. 2637-2645 ◽  
Author(s):  
Russell Ward ◽  
Nicholas Souder ◽  
Daniel Stahl ◽  
Felicia Hunter ◽  
Robert Probe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Oxide Synthase

Protective role of nitric oxide synthase against ischemia-reperfusion injury in guinea pig myocardial mitochondria

1999 ◽  
Vol 380 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Yoshihiro Hotta ◽  
Hidetsugu Otsuka-Murakami ◽  
Michiko Fujita ◽  
Junichi Nakagawa ◽  
Michio Yajima ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guinea Pig ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Myocardial Mitochondria ◽  
Oxide Synthase

scholarly journals Protective role of nitric oxide synthase in mitochondria against ischemia-reperfusion injury in guinea-pig hearts

1998 ◽  
Vol 76 ◽  
pp. 286
Author(s):  
Yoshihiro Hotta ◽  
Michiko Fujita ◽  
Junichi Nakagawa ◽  
Hidetugu Murakami ◽  
Michio Yajima ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guinea Pig ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Oxide Synthase

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines ◽  
2013 ◽  
Vol 24 (1) ◽  
pp. 13-19
Author(s):  
Benno Cardini ◽  
Rupert Oberhuber ◽  
Sven R. Hein ◽  
Katrin Watschinger ◽  
Martin Hermann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pathological State ◽  
Vascular Endothelial ◽  
Oxide Synthase

AbstractIschemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular endothelial dysfunction. Tetrahydrobiopterin supplementation has been shown to protect from this pathological state in a plethora of cardiovascular diseases including transplant-related ischemia-reperfusion injury. Even though still controversially discussed, there is increasing evidence emerging from both human as well as animal studies that tetrahydrobiopterin-mediated actions rely on its nitric oxide synthase cofactor activity rather than on its antioxidative properties. Herein, we review the current literature regarding the role of tetrahydrobiopterin in ischemia-reperfusion injury including our experience acquired in a murine pancreas transplantation model.

scholarly journals Protective role of nitric oxide synthase in myocardial mitochondria against ischemia-reperfusion injury in guinea pigs.

1999 ◽  
Vol 79 ◽  
pp. 175
Author(s):  
Yoshihiro Hotta ◽  
Hidetsugu Murakami ◽  
Michiko Fujita ◽  
Junichi Nakagawa ◽  
Naohisa Ishikawa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Guinea Pigs ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Myocardial Mitochondria ◽  
Oxide Synthase

Expression of Neuronal Nitric Oxide Synthase (nNOS) on Ischemia/reperfusion Injury in Rat Spinal Cord

2007 ◽  
Vol 52 (4) ◽  
pp. 449
Author(s):  
Hee Uk Kwon ◽  
Kwang Ho Lee ◽  
Po Soon Kang ◽  
Choon Kyu Cho ◽  
Chun Woo Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuronal Nitric Oxide Synthase ◽  
Rat Spinal Cord ◽  
Oxide Synthase

scholarly journals Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury

2002 ◽  
Vol 61 (3) ◽  
pp. 862-871 ◽  
Author(s):  
Prabal K. Chatterjee ◽  
Nimesh S.A. Patel ◽  
Espen O. Kvale ◽  
Salvatore Cuzzocrea ◽  
Paul A.J. Brown ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Inducible Nitric Oxide Synthase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
Sign in / Sign up

Export Citation Format

Share Document