scholarly journals Commentary on an article by Matthew D. Milewski, MD, et al.: “Lyme Arthritis in Children Presenting with Joint Effusions”

2011 ◽  
Vol 93 (3) ◽  
pp. e11-1-2
Author(s):  
R Mervyn Letts
Keyword(s):  
Lyme Arthritis ◽  
Joint Effusions

Lyme Arthritis in Children Presenting with Joint Effusions

2011 ◽  
Vol 93 (3) ◽  
pp. 252-260 ◽  
Author(s):  
Matthew D Milewski ◽  
Aristides I Cruz ◽  
Christopher P Miller ◽  
Ashley T Peterson ◽  
Brian G Smith
Keyword(s):  
Lyme Arthritis ◽  
Joint Effusions

Differentiating Between Lyme Arthritis and Septic Arthritic in Children Presenting with Knee Joint Effusions: The Predictive Role of Magnetic Resonance Imaging

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 566A-566A
Author(s):  
Yi-Meng Yen ◽  
Benjamin J Shore ◽  
Kyna S Donohue ◽  
Patricia E Miller ◽  
Michael Glotzbecker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Knee Joint ◽  
Lyme Arthritis ◽  
Resonance Imaging ◽  
Predictive Role ◽  
Joint Effusions

Lyme Arthritis: Highly Treatable, Slow to Resolve

2012 ◽  
Vol 42 (16) ◽  
pp. 18
Author(s):  
BRUCE JANCIN
Keyword(s):  
Lyme Arthritis

Lyme arthritis: linking infection, inflammation and autoimmunity

2021 ◽  
Author(s):  
Robert B. Lochhead ◽  
Klemen Strle ◽  
Sheila L. Arvikar ◽  
Janis J. Weis ◽  
Allen C. Steere
Keyword(s):  
Lyme Arthritis

scholarly journals Borrelia burgdorferiNapA-driven Th17 cell inflammation in lyme arthritis

2008 ◽  
Vol 58 (11) ◽  
pp. 3609-3617 ◽  
Author(s):  
Gaia Codolo ◽  
Amedeo Amedei ◽  
Allen C. Steere ◽  
Elena Papinutto ◽  
Andrea Cappon ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Lyme Arthritis

scholarly journals Arthritis and Diagnostics in Lyme Disease

2021 ◽  
Vol 6 (1) ◽  
pp. 18
Author(s):  
Javier A. Quintero ◽  
Raluchukwu Attah ◽  
Reena Khianey ◽  
Eugenio Capitle ◽  
Steven E. Schutzer
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Diagnostic Tests ◽  
Laboratory Tests ◽  
Diagnostic Methods ◽  
Lyme Arthritis ◽  
Differential Diagnoses ◽  
Antibody Testing ◽  
Active Infection ◽  
Indirect Measure

The diagnosis of Lyme disease, caused by Borrelia burgdorferi, is clinical but frequently supported by laboratory tests. Lyme arthritis is now less frequently seen than at the time of its discovery. However, it still occurs, and it is important to recognize this, the differential diagnoses, and how laboratory tests can be useful and their limitations. The most frequently used diagnostic tests are antibody based. However, antibody testing still suffers from many drawbacks and is only an indirect measure of exposure. In contrast, evolving direct diagnostic methods can indicate active infection.

Reliability of Total Nucleated Cell Counts in the Setting of Hip Arthroplasty

2020 ◽  
Author(s):  
Lauren N Pearson ◽  
Robert L Schmidt ◽  
Kenneth Cahoon ◽  
Christopher E Pelt
Keyword(s):  
Synovial Fluid ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Metal Debris ◽  
Total Hip ◽  
Cell Counts ◽  
History Of ◽  
Joint Effusions ◽  
Automated Instruments ◽  
Automated Methods

Abstract Background Total nucleated cell (TNC) count and differential are used to classify joint effusions as inflammatory or noninflammatory. Further diagnostic evaluation and management is contingent on this classification. TNC count can be measured by automated analyzers or by manual assessment using a hemocytometer. Studies have raised concerns regarding the accuracy of TNC counts measured by automated instruments, particularly in the setting of joint arthroplasty. The objective of this study was to determine whether metallosis, a complication of total hip arthroplasty in which metal debris accumulates in periprosthetic tissues and synovial fluid, is associated with inaccurate TNC counts in synovial fluid. Methods We compared the accuracy of cell counts measured by the Sysmex XN-1000 and Beckman Coulter Iris iQ200 with the gold standard of manual assessment using a hemocytometer in synovial fluid from patients with suspected metallosis and in fluid obtained from controls from patients with native joints and a history of arthroplasty for other indications. Results TNC counts produced by automated analyzers were associated with increased levels of discordance (relative to manual counts) in patients with metallosis. Metallosis was not associated with increased levels of discordance for RBC counts or WBC differentials. The Sysmex XN flagged all but 1 metallosis sample for manual verification of the results. Conclusions Automated methods are generally reliable for analysis of synovial fluid. TNC counts can be inaccurate in the context of metallosis following total hip arthroplasty. Laboratories should correlate automated cell counts with a microscopic assessment of the specimen, as recommended by instrument manufacturers.

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