scholarly journals The Relation of IGF-1 and Insulin Resistance in a Sample of Iraqi Obese Type 2 Diabetic Patients with Macrovascular Disease

2012 ◽  
Vol 9 (4) ◽  
pp. 656-662
Author(s):  
Baghdad Science Journal

Type 2 diabetes mellitus(T2DM) is a metabolic disease that is associated with an increased risk for atherosclerosis by 2-4 folds than in non- diabetics. In general population, low IGF-1 has been associated with higher prevalence of cardiovascular disease and mortality .This study aims to find out the relationship between IGF-1 level and other biochemical markers such as Homeostasis Model Assessment insulin resistance(HOMAIR) and Body Mass Index(BMI) in type 2 diabetic patients . This study includes (82) patients (40 females and 42 males) with age range (40-75) years,(34) non obese diabetic patients and (48) obese diabetic patients. The non obese individuals considered as a controls group, all controls and patients groups with type 2 DM, ischemic heart disease and hypertension, and free from other disease by history and clinical exam .The results showed that serum IGF-1 levels were lower in obese diabetic patients than non obese.HOMAIR has been found to be significantly higher in obese than non obese diabetic patients ,there is negative correlation between IGF-1 and HOMAIR. Body mass index (BMI) was in positive correlation with HOMAIR and innegativecorrelationwithIGF-1. Conclusion of this study was the serum level of IGF-1 is significantly lower in obese than non obese type 2 DM , but HOMA IR is significantly higher in obese diabetic subjects .

Metabolism ◽  
2004 ◽  
Vol 53 (2) ◽  
pp. 142-146 ◽  
Author(s):  
Sang Ah Chang ◽  
Hee Seung Kim ◽  
Kun Ho Yoon ◽  
Seung Hyun Ko ◽  
Hyuk Sang Kwon ◽  
...  

2016 ◽  
Vol 17 (3) ◽  
pp. 276.e15-276.e22 ◽  
Author(s):  
Kitty K.T. Cheung ◽  
Guozhi Jiang ◽  
Jenny S.W. Lee ◽  
Andrea O.Y. Luk ◽  
Alice P.S. Kong ◽  
...  

2018 ◽  
Vol 65 (3) ◽  
pp. 281-290 ◽  
Author(s):  
Yongmei Li ◽  
Xing Fan ◽  
Chunjun Li ◽  
Xinyue Zhi ◽  
Liyuan Peng ◽  
...  

2019 ◽  
Vol 6 (6) ◽  
pp. 1788
Author(s):  
Rakesh K. Sisodia ◽  
Mahendra Chouhan

Background: Obesity has major adverse effects on health. Obesity is associated with an increase in mortality, with a 50-100% increased risk of death from all causes compared to normal-weight individuals, mostly due to cardiovascular causes. The aim of this study was to correlate Body Mass Index (BMI) and glycaemic control (HbA1c) in type 2 Diabetic patients.Methods: In this study 100 patients of type 2 diabetic were subjected to detailed history, clinical examination, BMI, HbA1c and routine biochemical investigations.Results: Out of 100 diabetic patients included in this study 62 of them were male and 38 were female. Among 100 patients. Majority of patients were overweight (BMI 25-29.9) which is account to about 58 of total cases, 30 patients were normal BMI and 12 patients were obese. Statistical analysis a positive correlation found between BMI and poor glycaemic control (HbA1c), which is significant.Conclusions: From this study it was concluded that obesity (BMI) is associated with poor glycaemic control.


2013 ◽  
Vol 12 (1) ◽  
pp. 88 ◽  
Author(s):  
Hirofumi Nagao ◽  
Susumu Kashine ◽  
Hitoshi Nishizawa ◽  
Takuya Okada ◽  
Takekazu Kimura ◽  
...  

2018 ◽  
Vol 65 (7) ◽  
pp. 685-691 ◽  
Author(s):  
Huanhuan Zang ◽  
Fusong Jiang ◽  
Xingbo Cheng ◽  
Hong Xu ◽  
Xingna Hu

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