scholarly journals Advances in novel molecular typing and precise treatment strategies for small cell lung cancer

2021 ◽  
Vol 33 (4) ◽  
pp. 522-534
Author(s):  
Rilan Bai ◽  
◽  
Lingyu Li ◽  
Xiao Chen ◽  
Yuguang Zhao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Molecular Typing ◽  
Treatment Strategies ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Small cell lung cancer transformation during antitumor therapies: A systematic review

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1160-1167
Author(s):  
Xing Chai ◽  
Xinru Zhang ◽  
Wenqian Li ◽  
Jin Chai
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Treatment Strategies ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Histological Transformation ◽  
Nsclc Patients

Abstract Lung cancer is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major histological categories of lung cancers. Drug resistance is a great challenge for cancer treatment, and histological transformation from NSCLC to SCLC is one of the mechanisms underlying drug resistance in NSCLC patients. SCLC-transformed patients show combined characteristics of NSCLC and SCLC; however, they lack timely diagnoses and effective treatment strategies. Thus, we reviewed the clinical characteristics of SCLC transformation patients with a literature search to enhance clinical consciousness, diagnosis, and personalized treatment for patients with it.

scholarly journals Advances and Therapeutic Perspectives in Extended-Stage Small-Cell Lung Cancer

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3224
Author(s):  
Thomas Pierret ◽  
Anne-Claire Toffart ◽  
Matteo Giaj Levra ◽  
Denis Moro-Sibilot ◽  
Elisa Gobbini
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Treatment Algorithm ◽  
Treatment Strategies ◽  
Predictive Biomarkers ◽  
Small Cell ◽  
Small Cell Lung ◽  
Comprehensive Overview ◽  
First Choice

Extended small cell lung cancer (ED-SCLC) is a very aggressive disease, characterized by rapid growth and an early tendency to relapse. In contrast to non-small cell lung cancer, no therapeutic innovation has improved survival in patients with ED-SCLC over the past 20 years. Recently, immunotherapy has shown an important role in the management of these patients, emerging as the treatment of first choice in combination with chemotherapy and completely changing the therapeutic paradigm. However, patients’ selection for this strategy is still challenging due to a lack of reliable predictive biomarkers. Conversely, the immunotherapy efficacy beyond the first line is pretty disappointing and innovative chemotherapies or target agents seem to be more promising in this setting. Some of them are also under evaluation as an upfront strategy and they will probably change the treatment algorithm in the next future. This proposal provides a comprehensive overview of available treatment strategies for ED-SCLC patients, highlighting their strengths and weaknesses.

The role of genetic and other biomarkers in NSCLC prognosis

Open Medicine ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. 382-390
Author(s):  
Diana Schveigert ◽  
Saulius Cicenas ◽  
Jaroslav Bublevic ◽  
Renatas Askinis ◽  
Virginijus Sapoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Treatment Strategies ◽  
Small Cell ◽  
Cancer Prognosis ◽  
Lung Carcinogenesis ◽  
Small Cell Lung ◽  
Multistep Process ◽  
New Treatment

AbstractThe development of non-small-cell lung cancer (NSCLC) is a multistep process, which is triggered and maintained by various factors. Many steps of non-small-cell lung carcinogenesis, risk factors and biomarkers have been identified; however no consistent model has been established of personalized medicine for these patients. Distinct various gene expression, products of mutated genes and other markers such as circulating nucleic acids or tumor cells has been proven to be potential biomarkers of non-small cell lung cancer as well as potential targets for new treatment strategies. This article will highlight promising biomarkers in non-small cell lung cancer prognosis.

scholarly journals Molecular Analysis-Based Treatment Strategies for the Management of Non-small Cell Lung Cancer

2009 ◽  
Vol 4 (9) ◽  
pp. S1029-S1039 ◽  
Author(s):  
Howard West ◽  
Rogerio Lilenbaum ◽  
David Harpole ◽  
Antoinette Wozniak ◽  
Lecia Sequist
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Molecular Analysis ◽  
Cell Lung Cancer ◽  
Treatment Strategies ◽  
Small Cell ◽  
Small Cell Lung
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