scholarly journals Ormond’s disease accompanied by ankylosing spondylitis – a case report

2020 ◽  
Vol 66 (3) ◽  
Author(s):  
Paulina Żukowska ◽  
Jerzy Świerkot ◽  
Magdalena Szmyrka ◽  
Renata Sokolik ◽  
Piotr Wiland ◽  
...  

Idiopathic retroperitoneal fibrosis, or Ormond’s disease, is a rare syndrome which is in essence the deposition of pathological fibrous tissue in the retroperitoneal space. In most cases, it is initially asymptomatic, but as the disease progresses, clinical symptoms develop. The main complaint are abdominal pain and symptoms resulting from the involvement of ureters, arterial and venous vessels. Diagnosis is based on computed tomography or magnetic resonance imaging, demonstrating a fibrotic tissue mass accumulated in the retroperitoneal space. Due to the typically late presentation of clinical symptoms, a diagnosis is difficult and is often made after complications occur. In our article, we present the case of a 71-year-old patient in whom coexisting ankylosing spondylitis and retroperitoneal fibrosis were diagnosed 15 years after non-specific abdominal pain occurred.

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A1988-A1989
Author(s):  
Mariam Saeed ◽  
Muneer Khan ◽  
Moses Bachan ◽  
Zinobia Khan

1998 ◽  
Vol 65 (2) ◽  
pp. 253-256
Author(s):  
D. Schiavone ◽  
G. Carluccio

A presentation is given of the stages through which Ormond in 1962 managed to define Idiopathic Retroperitoneal Fibrosis (RPF), thereby giving it a precise clinical identity while the disease became known with his name. In the following years Ormond examined some etiopathogenetic hypotheses and showed that the etiology of RPF was still unknown, even if in some cases the cause had been traced to some medicines, such as methysergide, which were thought to act as haptens. The anatomical limits of the retroperitoneum and its structures are then outlined, in particular the retroperitoneal connective tissue.


1998 ◽  
Vol 65 (2) ◽  
pp. 267-271
Author(s):  
M. Chilosi ◽  
G. Mariuzzi

Histopathological studies have significantly contributed to clarifing the pathogenetic mechanisms of idiopathic retroperitoneal fibrosis (Ormond's disease), confirming in most cases its inflammatory nature. In this review we describe the principal pathologic features of the lesion, describing the different inflammatory and fibrogenic cell components. In addition, the differential diagnosis of Ormond's disease and the clinical role of histopathology and immunophenotypical analysis are briefly discussed.


2002 ◽  
Vol 69 (5) ◽  
pp. 502-505 ◽  
Author(s):  
A Bezza ◽  
A El Maghraoui ◽  
M Ghadouane ◽  
F Tabache ◽  
A Abouzahir ◽  
...  

2020 ◽  
Vol 8 (1) ◽  
pp. 101-107
Author(s):  
S.V. Shchekaturov ◽  
◽  
M.M. Kaabak ◽  
A.K. Zokoev ◽  
E.R. Charchyan ◽  
...  

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 919 ◽  
Author(s):  
Viggiano ◽  
Madej-Pilarczyk ◽  
Carboni ◽  
Picillo ◽  
Ergoli ◽  
...  

X-linked Emery–Dreifuss muscular dystrophy (EDMD1) affects approximately 1:100,000 male births. Female carriers are usually asymptomatic but, in some cases, they may present clinical symptoms after age 50 at cardiac level, especially in the form of conduction tissue anomalies. The aim of this study was to evaluate the relation between heart involvement in symptomatic EDMD1 carriers and the X-chromosome inactivation (XCI) pattern. The XCI pattern was determined on the lymphocytes of 30 symptomatic and asymptomatic EDMD1 female carriers—25 familial and 5 sporadic cases—seeking genetic advice using the androgen receptor (AR) methylation-based assay. Carriers were subdivided according to whether they were above or below 50 years of age. A variance analysis was performed to compare the XCI pattern between symptomatic and asymptomatic carriers. The results show that 20% of EDMD1 carriers had cardiac symptoms, and that 50% of these were ≥50 years of age. The XCI pattern was similar in both symptomatic and asymptomatic carriers. Conclusions: Arrhythmias in EDMD1 carriers poorly correlate on lymphocytes to a skewed XCI, probably due to (a) the different embryological origin of cardiac conduction tissue compared to lymphocytes or (b) the preferential loss of atrial cells replaced by fibrous tissue.


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