MANAGEMENT STRATEGY FOR RECURRENT HEAD AND NECK CANCER FOLLOWING CHEMORADIATION AND CHALLENGES IN DECISION MAKING FOR SURGICAL SALVAGE OF LOCO-REGIONAL DISEASE

Author(s):  
D R NAYAK ◽  
◽  
Suraj Nair ◽  
Balakrishnan R ◽  
Asheesh Dora ◽  
...  
Author(s):  
Mitchell Machtay ◽  
David I Rosenthal ◽  
Ara A Chalian ◽  
Robert Lustig ◽  
Diane Hershock ◽  
...  

2020 ◽  
Vol 29 (1) ◽  
pp. 377-385
Author(s):  
Bethany A. Rhoten ◽  
Jessie I. Sellers ◽  
Breanna Baraff ◽  
Kelly H. Holler ◽  
Sheila H. Ridner

Head & Neck ◽  
2013 ◽  
Vol 36 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Allen S. Ho ◽  
Dennis H. Kraus ◽  
Ian Ganly ◽  
Nancy Y. Lee ◽  
Jatin P. Shah ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1910
Author(s):  
Kaley Woods ◽  
Robert K. Chin ◽  
Kiri A. Cook ◽  
Ke Sheng ◽  
Amar U. Kishan ◽  
...  

This study evaluates the potential for tumor dose escalation in recurrent head and neck cancer (rHNC) patients with automated non-coplanar volumetric modulated arc therapy (VMAT) stereotactic body radiation therapy (SBRT) planning (HyperArc). Twenty rHNC patients are planned with conventional VMAT SBRT to 40 Gy while minimizing organ-at-risk (OAR) doses. They are then re-planned with the HyperArc technique to match these minimal OAR doses while escalating the target dose as high as possible. Then, we compare the dosimetry, tumor control probability (TCP), and normal tissue complication probability (NTCP) for the two plan types. Our results show that the HyperArc technique significantly increases the mean planning target volume (PTV) and gross tumor volume (GTV) doses by 10.8 ± 4.4 Gy (25%) and 11.5 ± 5.1 Gy (26%) on average, respectively. There are no clinically significant differences in OAR doses, with maximum dose differences of <2 Gy on average. The average TCP is 23% (± 21%) higher for HyperArc than conventional plans, with no significant differences in NTCP for the brainstem, cord, mandible, or larynx. HyperArc can achieve significant tumor dose escalation while maintaining minimal OAR doses in the head and neck—potentially enabling improved local control for rHNC SBRT patients without increased risk of treatment-related toxicities.


2021 ◽  
Vol 161 ◽  
pp. S855
Author(s):  
J. von der Grün ◽  
A. Altay-Langguth ◽  
P. Balermpas ◽  
C. Brandts ◽  
S. Balster ◽  
...  

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