The technology of horizontal well emerges in 1970s-1980s, mainly from the standard length of the horizontal well, the reasonable level in the reservoir, trajectory optimization of the level to ensure the level and get the best production results. Numerical simulation is the most effective and accurate way to optimize the parameters of horizontal well, to understand the geology in this article, based on the use of reservoir simulation methods, looking for the benefit of regional development of horizontal well, and the Optimization methods to determine the length of the horizontal wells and production parameters, design two-level horizontal well in TZ422 oilfield of Tower, and achieved good results.