scholarly journals p38 Mitogen-Activated Protein Kinase and Liver X Receptor-α Mediate the Leptin Effect on Sterol Regulatory Element Binding Protein-1c Expression in Hepatic Stellate Cells

2011 ◽  
Vol 18 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Kunfeng Yan ◽  
Xiong Deng ◽  
Xuguang Zhai ◽  
Mingming Zhou ◽  
Xin Jia ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Hepatic Stellate Cells ◽  
Regulatory Element ◽  
Stellate Cells ◽  
Liver X Receptor ◽  
Mitogen Activated Protein Kinase ◽  
Liver X Receptor Α ◽  
Mitogen Activated Protein ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor α, liver X receptor α and sterol regulatory element-binding protein-1c

2002 ◽  
Vol 61 (3) ◽  
pp. 371-374 ◽  
Author(s):  
Sander Kersten
Keyword(s):  
Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Liver X Receptor ◽  
Dietary Fatty Acids ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Liver X Receptor Α ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.

scholarly journals Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver

2007 ◽  
Vol 282 (16) ◽  
pp. 11687-11695 ◽  
Author(s):  
Takashi Yamamoto ◽  
Hitoshi Shimano ◽  
Noriyuki Inoue ◽  
Yoshimi Nakagawa ◽  
Takashi Matsuzaka ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Binding Protein ◽  
Regulatory Element ◽  
Liver X Receptor ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Kinase A
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