scholarly journals SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

2020 ◽  
Author(s):  
Valeria Salinas ◽  
Juana Villarroel ◽  
Hernán Silva ◽  
Luisa Herrera ◽  
Sonia Jerez ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Genetic Factors ◽  
Borderline Personality ◽  
Genetic Constitution ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
S Allele ◽  
The Brain

Abstract Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.Results We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

scholarly journals SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

2020 ◽  
Author(s):  
Valeria Salinas ◽  
Juana Villarroel ◽  
Hernán Silva ◽  
Luisa Herrera ◽  
Sonia Jerez ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Genetic Factors ◽  
Borderline Personality ◽  
Genetic Constitution ◽  
Bdnf Gene ◽  
Bdnf Val66met Polymorphism ◽  
S Allele ◽  
The Brain

Abstract Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

scholarly journals SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

2019 ◽  
Author(s):  
Valeria Salinas ◽  
Juana Villarroel ◽  
Hernán Silva ◽  
Luisa Herrera ◽  
Sonia Jerez ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Genetic Factors ◽  
Borderline Personality ◽  
Genetic Constitution ◽  
Bdnf Gene ◽  
Bdnf Val66met Polymorphism ◽  
S Allele ◽  
The Brain

Abstract Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

Borderline Personality Disorder and the Big Five: Molecular Genetic Analyses Indicate Shared Genetic Architecture with Neuroticism and Openness

2021 ◽  
Author(s):  
Fabian Streit ◽  
Stephanie Witt ◽  
Swapnil Awasthi ◽  
Jerome Foo ◽  
Martin Jungkunz ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Big Five ◽  
Genetic Factors ◽  
Five Factor Model ◽  
Genetic Correlations ◽  
Borderline Personality ◽  
A Genome ◽  
Shared Genetic

Abstract Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic factors underlying these symptoms/features are shared in part with the personality traits of the Five Factor Model (FFM) of personality – the “Big Five". In the present study, the genetic overlap of BPD with the Big Five -Openness to Experience, Conscientiousness, Extraversion, Agreeableness and Neuroticism- was assessed. Linkage disequilibrium score regression was used to calculate genetic correlations between a genome-wide association study (GWAS) in central European populations on BPD (N = 2,543) and GWAS on the “Big Five” (N = 76,551–122,886, Neuroticism N = 390,278). Significant positive genetic correlations were found between BPD and the traits Neuroticism (rg=.34, p=6.3*10−5) and Openness (rg=.24, p=.036), but not between BPD and the other personality traits (all |rg|<.14, all p>.30). A cluster and item-level analysis showed positive correlations with the Neuroticism clusters “Depressed Affect” and “Worry”, and with a broad range of Neuroticism items (N = 348,219 – 376,352). The observed associations indicate a partially shared genetic background of BPD and the personality traits Neuroticism and Openness. Larger GWAS of BPD and the “Big Five” are needed to further explore the role of personality traits in the etiology of this disorder.

Interaction effects between the brain-derived neurotrophic factor Val66Met polymorphism and parental rearing on personality traits in healthy subjects

2011 ◽  
Vol 26 (S2) ◽  
pp. 817-817
Author(s):  
A. Suzuki ◽  
Y. Matsumoto ◽  
N. Shibuya ◽  
R. Sadahiro ◽  
M. Kamata ◽  
...  
Keyword(s):  
Personality Traits ◽  
Maternal Care ◽  
Healthy Subjects ◽  
Harm Avoidance ◽  
Novelty Seeking ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
Parental Rearing ◽  
Main Effects ◽  
The Brain

AimsThere is a growing body of data suggesting the gene-environment interaction in the characterization of personality traits, but variation in ordinary parental rearing among environmental factors has not been focused yet. We examined the effects of the interaction between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and parental rearing on personality traits.MethodsSubjects were 710 Japanese healthy volunteers. Perceived parental rearing was assessed by the Parental Bonding Instrument (PBI), which consists of the care and protection factors. Personality assessment was performed by the Temperament and Character Inventory (TCI), which has 7 dimensions, i.e., novelty seeking, harm avoidance, reward dependence, persistence, self-directedness, cooperativeness, and self-transcendence. The BDNF Val66Met polymorphism was detected by the PCR-RFLP method.ResultsParental rearing has significant main effects on all TCI dimensions except novelty seeking, while no significant main effects of the BDNF genotype on the TCI scores were found. The interaction between the BDNF genotype and maternal care of the PBI had significant effects on harm avoidance and self-directedness of the TCI. Post-hoc analyses showed that decreased maternal care was correlated with increased harm avoidance and decreased self-directedness in most of the genotype groups, and for both personality traits the correlation was highest in the Met/Met genotype and lowest in the Val/Val genotype and that for the Val/Met genotype was in between the two values.ConclusionThe present study suggests that the BDNF Val66Met polymorphism moderates the effects of parenting rearing, especially maternal care, on harm avoidance and self-directedness in healthy subjects.

Screening for depression with the Edinburgh Postnatal Depression Scale and finding borderline personality disorder

2018 ◽  
Vol 53 (5) ◽  
pp. 424-432 ◽  
Author(s):  
Fiona Judd ◽  
Stephanie Lorimer ◽  
Richard H Thomson ◽  
Angela Hay
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Personality Traits ◽  
Pregnant Women ◽  
Postnatal Depression ◽  
Edinburgh Postnatal Depression Scale ◽  
Past History ◽  
Depression Scale ◽  
Borderline Personality ◽  
Borderline Personality Traits

Objective: The aim of the study was to explore the range of psychiatric diagnoses seen in pregnant women who score above the ‘cut-off’ on the Edinburgh Postnatal Depression Scale when this is used as a routine screening instrument in the antenatal period. Method: Subjects were all pregnant women referred to and seen by the Perinatal Consultation-Liaison Psychiatry Team of a tertiary public hospital over a 14-month period. Edinburgh Postnatal Depression Scale score at maternity ‘booking-in’ visit, demographic and clinical data were recorded and diagnoses were made according to Diagnostic and Statistical Manual of Mental Disorders (5th ed.) criteria following clinical interview(s) and review of documented past history. Data were analysed using descriptive statistics. Results: A total of 200 patients who had completed the Edinburgh Postnatal Depression Scale were seen for assessment; 86 (43%) scored ⩾13 on Edinburgh Postnatal Depression Scale. Of those scoring 13 or more on Edinburgh Postnatal Depression Scale, 22 (25.6%) had a depressive disorder. In total, 12 patients (14%) had an anxiety disorder, 14 (16.3%) had borderline personality disorder and 13 (15.1%) had a substance use disorder. An additional 23 women (26.7%) had two or more borderline personality traits. Conclusion: Psychiatric assessment of women who scored 13 or more on the Edinburgh Postnatal Depression Scale at routine antenatal screening identified a significant number with borderline personality disorder or borderline personality traits rather than depressive or anxiety disorders. Clinical Practice Guidelines note the importance of further assessment for all women who score 13 or more on the Edinburgh Postnatal Depression Scale. The findings here suggest that this assessment should be made by a clinician able to identify personality pathology and organise appropriate and timely interventions.

scholarly journals Borderline personality disorder in twins: the preponderance of environmental and genetic factors

10.3823/1655 ◽  
2015 ◽  
Author(s):  
Hiroê Alencar Braga ◽  
Ákila Macêdo Freire ◽  
Araly Alencar Braga ◽  
João Marcos Ferreira de Lima Silva ◽  
Modesto Leite Rolim Neto
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Genetic Factors ◽  
Borderline Personality
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