scholarly journals Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Optical Parameter ◽  
Vessel Density ◽  
Normal Adult ◽  
Optical Coherence ◽  
Healthy Humans ◽  
Cynomolgus Macaques ◽  
Optic Discs

Abstract Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169, retrospectively registered on 26 sept 2018 Keywords: Cynomolgus macaques, Healthy humans, Vascular, Optical coherence tomography angiography (OCT-A), Vessel density (VD)

scholarly journals Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Optical Parameter ◽  
Vessel Density ◽  
Normal Adult ◽  
Optical Coherence ◽  
Healthy Humans ◽  
Cynomolgus Macaques ◽  
Optic Discs

Abstract Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169, retrospectively registered on 26 sept 2018 Keywords: Cynomolgus macaques, Healthy humans, Vascular, Optical coherence tomography angiography (OCT-A), Vessel density (VD)

scholarly journals Vascular parameters of normal cynomolgus macaques and healthy humans obtained by fundus fluorescence angiography and optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Parameter ◽  
Fluorescence Angiography ◽  
Optical Coherence ◽  
Advantages And Disadvantages ◽  
Healthy Humans ◽  
En Face ◽  
Cynomolgus Macaques ◽  
Optic Discs

Abstract Background: To provide and compare normal vascular parameters for cynomolgus macaques and healthy humans, compare the advantages and disadvantages of fundus fluorescence angiography (FFA) and optical coherence tomography angiography (OCT-A) in angiography, and establish an eye parameter database for cynomolgus macaques and healthy humans. Methods: 5 normal cynomolgus macaques with a mean age of 4.60±0.55 years were studied for data collection. A Heidelberg Spectralis® HRA+OCT was used to obtain parameters for FFA. The macula of 28 healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macula and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: FFA of cynomolgus macaques revealed stages similar to those observed in humans. OCT-A was used to image the superficial and deep capillary plexuses and radial peripapillary capillary network. The highest entire en-face mean VD in the macular area was 68.19±0.75% in the choroid capillary layer. In both layers of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for cynomolgus macaques using FFA and OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169

scholarly journals Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optic Disc ◽  
Optical Parameter ◽  
Normal Adult ◽  
Healthy Humans ◽  
Cynomolgus Macaques ◽  
Circulation Parameters ◽  
Temporal Quadrant ◽  
Optic Discs ◽  
Ophthalmic Disease ◽  
Radial Peripapillary Capillary

Abstract Background The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods Twelve normal adult cynomolgus macaques with a mean age of 4.91 ± 0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11 ± 6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56 ± 6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3 × 3 mm and 4.5 × 4.5 mm, respectively. Results OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration Current Controlled Trials NCT03692169, retrospectively registered on 26 sept 2018.

scholarly journals Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optic Disc ◽  
Optical Parameter ◽  
Normal Adult ◽  
Healthy Humans ◽  
Cynomolgus Macaques ◽  
Circulation Parameters ◽  
Temporal Quadrant ◽  
Optic Discs ◽  
Ophthalmic Disease ◽  
Radial Peripapillary Capillary

Abstract Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169

scholarly journals Vascular Parameters of Normal Cynomolgus Macaques by Fundus Fluorescence Angiography and Optical Coherence Tomography Angiography

2018 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Parameter ◽  
Vessel Density ◽  
Fluorescence Angiography ◽  
Optical Coherence ◽  
Advantages And Disadvantages ◽  
En Face ◽  
Cynomolgus Macaques ◽  
Capillary Plexus

Abstract Background: To provide normal vascular parameters for cynomolgus macaques. Compare the advantages and disadvantages of Fundus fluorescence angiography (FFA) and Optical coherence tomography angiography (OCT-A) in angiography. To establish an eye parameter database for cynomolgus macaques. Methods: Five normal cynomolgus macaques were studied for the collection of data, with a mean age of 4.6±0.55 years. The Heldelberg Spectralis® HRA+OCT was used to obtain parameters for Fundus fluorescence angiography (FFA). The vessel density was measured using the RTVue XR with AngioVue (software version 2017.1.0.155; Optovue, Inc., Fremont, CA, USA); the scan sizes of the macular and optic discs were 3×3mm and 4.5×4.5mm, respectively. Results: Cynomolgus macaque's fundus fluorescence angiography had similar stages as those found in humans. Optical coherence tomography can image the superficial, deep capillary plexus and the radial peripapillary capillary network. The highest whole En-face mean vessel density (VD) in the macular area was 68.19±0.75 % in the choroid capillary layer. In both layers of the optic disc, the vessel density in the Nasal quadrant was lower than in the inferior-tempo quadrant. Conclusions: This is a rare research, where we have collected the normal FFA and the novel OCT-A parameters for cynomolgus macaques. This study provides normal vascular parameters of cynomolgus macaques via Fundus fluorescence angiography (FFA) and Optical coherence tomography angiography (OCT-A), helping to establish an optical parameter database for cynomolgus macaques, promoting choroid-retinopathy research.

scholarly journals Comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography

2019 ◽  
Author(s):  
Jingyi Peng ◽  
Liuxueying Zhong ◽  
Li Ma ◽  
Jiayi Jin ◽  
Yongxin Zheng ◽  
...  
Keyword(s):  
Optic Disc ◽  
Optical Parameter ◽  
Normal Adult ◽  
Healthy Humans ◽  
Cynomolgus Macaques ◽  
Circulation Parameters ◽  
Temporal Quadrant ◽  
Optic Discs ◽  
Ophthalmic Disease ◽  
Radial Peripapillary Capillary

Abstract Background: The metabolic activity of retina is higher than other human tissues and is crucial to the vision. Cynomolgus macaques is widely used in ophthalmic disease research. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using OCT-A can promote better use of nonhuman primate models in studies of ophthalmic vascular disease. Methods: 12 normal adult cynomolgus macaques with a mean age of 4.91±0.43 years were studied for data collection. The macula of 28 adult healthy humans (14 males and 14 females), with a mean age of 25.11±6.21 years and the optic discs of 9 adult healthy humans (4 males and 5 females) with a mean age of 28.56±6.78 years were measured. The vessel density (VD) was measured using an RTVue XR with AngioVue. The scan sizes of the macular and optic discs were 3×3 mm and 4.5×4.5 mm, respectively. Results: OCT-A can image the superficial and deep capillary plexuses and radial peripapillary capillary network. In RPC layer of the optic disc, the VD in the nasal quadrant was lower than the VD in the inferior temporal quadrant. Similarities and significant differences in VD between healthy humans and cynomolgus macaques were obtained using OCT-A. Conclusions: This study provides normal vascular parameters for adult cynomolgus macaques using OCT-A to help establish an optical parameter database for cynomolgus macaques and compare VD between healthy humans and cynomolgus macaques to promote choroid-retinopathy research. Trial registration: Current Controlled Trials NCT03692169

scholarly journals Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lu Xiang ◽  
Yingming Zhou ◽  
Yanwei Chen ◽  
Siyu Jiang ◽  
Chunli Fei ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Preschool Children ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Retinal Vasculature ◽  
Optical Coherence ◽  
Significant Difference ◽  
Capillary Plexus ◽  
The Mean

Abstract Purpose To establish normal parameters of macular and optic disc vasculature by optical coherence tomography angiography (OCTA) in healthy preschool children aged 4–6 years old in China. OCTA reflects retinal metabolism and development in children at these ages and could be used clinically and in future studies to aid diagnosis and prediction of retinal abnormalities and developmental stagnation. Methods In this cross-sectional study, we measured foveal, parafoveal, and perifoveal vessel density in the superficial capillary plexus (SCP); the deep capillary plexus (DCP), the foveal avascular zone (FAZ), and the radial capillary peripapillary (RPC) in the optic disc using investigational spectral-domain OCTA. The magnification effect of the FAZ area and microvasculature measurements was corrected by Littman and the modified Bennett formula. Results A total of 242 eyes (116 males and 126 females, 5.31 ± 0.73 years) were recruited for the analysis. The mean macular vessel density was 48.10 ± 2.92% and 48.74 ± 6.51% in the SCP and the DCP, respectively. The RPC vessel density was 47.17 ± 2.52%, 47.99 ± 4.48%, and 48.41 ± 3.07% in the whole image, inside disc, and peripapillary, respectively; and the mean FAZ area was 0.28 ± 0.11 mm2. A significant difference between male and female participants was found in the retinal vasculature (DCP, SCP, and RPC). None of these parameters were significantly different in age (P > 0.05), except that DCP slightly increased with aging. The right and left eyes had good consistency in the parameters of the macula and optic disc. Conclusions Our study establishes the macular and optic disc OCTA reference values in 4- to 6-year-old healthy preschool children. They may be used in longitudinal OCTA studies and clinical applications.

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