scholarly journals Electrophysiological assessment of peripheral nerves and neuro-muscular junctions in patients following self-poisoning with paraquat

2021 ◽  
Author(s):  
Sudheera S Jayasinghe ◽  
Kithsiri D Pathirana ◽  
Klintean Wunnapuk ◽  
A W K Mithunika ◽  
H M N W Chandrasiri ◽  
...  
Keyword(s):  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Peripheral Nerves ◽  
Nerve Conduction Velocity ◽  
Cardiovascular Response ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Paraquat Poisoning ◽  
F Wave

Abstract Paraquat is neurotoxic. We aimed to study the electrophysiological effects of peripheral nerves and neuromuscular junction (NMJ) in the survivors of paraquat poisoning. A cohort study was conducted on patients following paraquat poisoning. Controls were recruited. The assessments were performed around one and six weeks after the exposure. Motor nerve conduction velocity (MNCV), amplitude of compound muscle action potential (CMAP), sensory nerve conduction velocity (SNCV), F-wave studies, cardiovascular response to different stimuli, sympathetic skin response (SSR) studies, and exercise modified supramaximal slow repetitive stimulation (RNS) and electromyography (EMG) were performed. There were 28 (21 males) patients and 56 controls. The mean (SD) age of the patients and the controls were 29 (12) and 31 (11) years. Significant impairment at the first assessment in the SNCV of ulnar nerve, amplitude of ulnar nerve CMAP on distal stimulation, and F-wave occurrence in median, ulnar and tibial nerves; change of systolic blood pressure three minutes after standing and SSR amplitude ( vs controls) was observed. All parameters reverted to normal at six weeks after the exposure. There was electrophysiological evidence for somatic nerve, autonomic, and NMJ dysfunction following acute paraquat poisoning which was not seen at six weeks after the exposure.

scholarly journals Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice

2014 ◽  
Vol 115 (6) ◽  
pp. 577-580 ◽  
Author(s):  
Chongshan Dai ◽  
Shusheng Tang ◽  
Jichang Li ◽  
Jiping Wang ◽  
Xilong Xiao
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Sensory Nerve ◽  
Sensory Nerve Conduction Velocity ◽  
F Wave

Serial changes of sensory nerve conduction velocity and minimal F-wave latency in streptozotocin-induced diabetic rats

1998 ◽  
Vol 244 (3) ◽  
pp. 169-172 ◽  
Author(s):  
Noriaki Kato ◽  
Mitsuhiro Makino ◽  
Kuniharu Mizuno ◽  
Tsunemasa Suzuki ◽  
Masaomi Shindo
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Sensory Nerve ◽  
Diabetic Rats ◽  
Sensory Nerve Conduction Velocity ◽  
F Wave ◽  
Wave Latency

scholarly journals Effect of pregnancy on median and ulnar nerve conduction

2017 ◽  
Vol 5 (3) ◽  
pp. 978
Author(s):  
Sapana S. Motewar ◽  
Narendra P. Bachewar
Keyword(s):  
Action Potential ◽  
Pregnant Women ◽  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Sensory Nerve ◽  
Action Potential Amplitude ◽  
Minimum Latency ◽  
Sensory Latency

Background: Pregnancy causes altered function of excitable membranes such as muscle and nerve, due to hormonal changes and edema. We failed to find any studies focusing on the issue of nerve conduction during pregnancy, in India. Thus present study aims to see the difference between nerve conduction parameters viz. motor and sensory conduction, in pregnant and non-pregnant women.Methods: This was a cross-sectional study carried out in randomly selected 30 pregnant women, of any age, in 28-40 weeks of gestation and age matched non-pregnant controls. We studied distal motor latency, compound muscle action potential amplitude, motor nerve conduction velocity, F-minimum latency, sensory latency, sensory nerve action potential amplitude and sensory nerve conduction velocity in bilateral median and ulnar nerves using Aleron-RMS.Results: Present study found no statistically significant difference between motor and sensory conduction of above said nerves in pregnant and nonpregnant women, except F minimum latency of left median nerve in pregnant women and sensory latency of left ulnar nerve in non-pregnant women were prolonged significantly (p<0.05).Conclusions: All motor and sensory parameters of bilateral median and ulnar nerves were normal as compared to non-pregnant controls.

Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome

2020 ◽  
Vol 20 ◽  
Author(s):  
Riccardo Marvulli ◽  
Giancarlo Ianieri ◽  
Grazia Devenuto ◽  
Marta Falcicchio ◽  
Giulia A. Gallo ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Sleep Quality ◽  
Conduction Velocity ◽  
Carpal Tunnel ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Pantothenic Acid ◽  
Sensory Nerve ◽  
Sensory Nerve Conduction Velocity ◽  
Tunnel Syndrome

Background and Objective: Carpal tunnel syndrome (CTS) is the most common form of nerve entrapment. Clinically, various signs and symptoms compare due to overexposure to mechanical vibrations transmitted to the wrist bones and cartilage, resulting in compression of the sensory and motor nerve fibers of median nerve. Early symptoms include nocturnal paresthesia and electromyography reveals reduced sensory nerve conduction velocity. Aim of this study was to evaluate the efficacy of a dietary integrator composed of acetyl-L-carnitine, α-lipoic acid,quercetin, bromelain, pantothenic acid, C and B1 and B2 and B6 and B12 vitamins in patients with early (minimal) carpal tunnel syndrome. Methods: 36 patients (28 female and 8 male) with early CTS characterized by sensory nerve demyelination and inflammation of the transverse carpal ligament. Patients were divided into two groups, group A (18 patients received physical therapy) and group B (18 patients, received physical therapy and an oral integrator). Clinical (sleep quality questionnaire to measure severity of paresthesia) and neurophysiological assessment (Sensory Nerve Conduction Velocity) performed at baseline, and then at 30 and 60 days after treatment. Results: Sleep quality and Sensory Nerve Conduction Velocity data analysis show improvement in both groups at 30 and 60 days, with statistically difference between them in both time of analysis. Conclusions: In the early CTS, with sensory fibers damage, use of dietary integrator, such as Micronil Dol®, composed composed of acetyl-L-carnitine, α-lipoic acid,quercetin, bromelain, pantothenic acid, C and B1 and B2 and B6 and B12 vitamins can be effective in quick recovery of median nerve sensory.

scholarly journals Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study

2021 ◽  
Vol 9 (1) ◽  
pp. e001698
Author(s):  
Haifa Maalmi ◽  
Kristiaan Wouters ◽  
Hans H C M Savelberg ◽  
Jeroen H P M van der Velde ◽  
Jos P H Reulen ◽  
...  
Keyword(s):  
T Cells ◽  
Adaptive Immunity ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Essential Feature ◽  
Sensory Nerve ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Innate And Adaptive Immunity

IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.

scholarly journals Two measurement methods of motor ulnar nerve conduction velocity at the elbow: A comparative study

2007 ◽  
Vol 55 (2) ◽  
pp. 145 ◽  
Author(s):  
H Mahmoudi ◽  
K Azma ◽  
K Bahmanteimoury ◽  
B Tavana ◽  
FR Moghaddam ◽  
...  
Keyword(s):  
Comparative Study ◽  
Ulnar Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Measurement Methods

scholarly journals Normal neurophysiologic parameters of the median nerve among adult healthy Sudanese population

2020 ◽  
Vol 10 (4) ◽  
pp. 136-141
Author(s):  
Mohammed Salah Elmagzoub ◽  
Ahmed Hassan Ahmed ◽  
Hussam M A Hameed
Keyword(s):  
Action Potential ◽  
Median Nerve ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Peak Latency ◽  
Muscle Action Potential ◽  
Sensory Nerve Action

Background: Nerve conduction studies (NCSs) help in delineating the extent distribution of neural lesion, and the diagnosis of peripheral nerve disorders. Because normative nerve conduction parameters were not yet established in Sudan EMG laboratories, this study aims towards having our own reference values, as we are using the American and British parameters. This will allow avoiding the discrepancies that might be induced by many factors. Methods: NCSs were performed in 200 Median nerves of 100 adult healthy Sudanese subjects using standardized techniques. Results: The median SNAP (sensory nerve action potential) values were as follows: distal latency, 2.6±3 ms with a range of (2.3-2.9); peak latency, 3.5±0.5 ms (3.0-4.0); amplitude, 47.7±18.0μV (29.7-65.7); conduction velocity, 53.0±7.8 m/s (45.2-60.8). The following values were obtained for the Median nerve CMAP (compound muscle action potential) at wrist stimulation: distal latency, 3.5±0.5 ms with a range of (3.0-4.0); peak latency, 9.4± 1.0 ms (8.4-10.4); duration, 5.9±0.9 ms (5.0-6.8); amplitude, 12.3±2.5 mV (9.8-14.8); area, 43.0±10.4 mVms (32.6-53.4); conduction velocity, 63.6±6.2 m/s (57.4-69.8). The F wave was 28.4±1.8 ms (26.6-30.2). Conclusion: The overall mean sensory and motor nerve conduction parameters for the tested nerve compared favorably with the existing literature with some discrepancies that were justified.

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