Longitudinal Evolution of Cognitive Function in Colorectal and Breast Cancer Survivors Treated with (Neo)Adjuvant Chemotherapy.

Abstract Introduction & objectives: Advances in early diagnosis and treatment are improving the long-term survival of patients with cancer. Cancer-related cognitive impairment (CRCI) is often reported as a long-term chemotherapy sequel. Improving the knowledge of CRCI may help to prevent, manage and identify risk factors. Our main goal is to assess the cognitive function evolution and determine the potential influence of chemotherapy in neurological decline. Material and methods We designed a prospective and longitudinal study of a colorectal and breast cancer patient cohort (n=62) and we assessed cognitive function evolution using a battery of 11 neuropsychological tests at three time points: baseline, post chemotherapy and 6 months after finishing chemotherapy. Sociodemographic features, quality of life, anxiety and depression status were recorded as well as their interplay with cognitive evolution. Results At baseline, 14.5% of the patients had cognitive dysfunction. Older age, low level of education, colorectal cancer and comorbidities were associated to initial cognitive damage. A total of 61.9% of patients presented a decline of scores in 4 or more tests from baseline to post chemotherapy assessment. This percentage decreased to 24.4% in the late follow up evaluation, showing an intra-patient recovery after chemotherapy. Verbal and visual memory is the domain most affected. Conclusion Our data suggest that cognitive function of cancer patients treated with chemotherapy may subtly but transiently decline during treatment, with most patients recovering their cognitive function over time. Further research is needed in this field as CRCI continues to impact on quality of life and mental well-being.

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A comparison of the clinical determinants of health-related quality of life and subjective well-being in long-term breast cancer survivors

European Journal of Cancer Care ◽

10.1111/j.1365-2354.2012.01344.x ◽

2012 ◽

Vol 21 (5) ◽

pp. 692-700 ◽

Cited By ~ 14

Author(s):

P. TESSIER ◽

S. LELORAIN ◽

A. BONNAUD-ANTIGNAC

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Breast Cancer Survivors ◽

Well Being ◽

Subjective Well Being ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Physical activity and body weight of breast cancer survivors – VICAN national survey

European Journal of Public Health ◽

10.1093/eurpub/ckaa165.1273 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

D Rey ◽

R Touzani ◽

A Monet ◽

M K Bendiane ◽

A D Bouhnik ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Healthy Lifestyle ◽

Well Being ◽

Healthy Habits ◽

Mental Well Being

Abstract Background Cancer recurrence and poor quality of life are major challenges of the growing population of breast cancer (BC) survivors. International guidelines encourage survivors to engage in regular physical activity (PA) and to maintain a healthy body weight (BW), as both have a proven benefit on survival. Our aims were (1) to describe PA and BW 5 years after a BC diagnosis and (2) to define the predictors of long-term engagement in healthy lifestyle, in a representative sample of French survivors. Methods The French National VICAN surveys were implemented in 2012 and 2015 among cancer survivors. This analysis focused on 723 women with BC, without progression at 5 years, and who participated in both surveys. The questionnaires dealt with several topics including socioeconomic status, treatments and side effects, psychometric scales and lifestyle habits. Results Five years after diagnosis, 26% of women reported regular PA, 61% occasional PA and 14% no PA. Moreover, 27% reported a weight gain ≥5kg, and 10% a weight loss ≥5kg. Half of the women had decreased or stopped PA since diagnosis. In logistic regression, long-term regular PA was associated with better mental quality of life (aOR=1.04; 1.01-1.07), no depression (aOR=3.42; 1.21-9.65), higher Post Traumatic Growth Inventory score (aOR=1.02; 1.01-1.04), normal arm mobility (aOR=3.7; 1.6-8.4) and healthy and stable BW since diagnosis (aOR=4.47; 1.61-12.37). Weight gain ≥5kg was associated with younger age (aOR=0.96; 0.93-0.99), higher BW at diagnosis (aOR=1.02; 1.01-1.04), and lymphedema 5 years after diagnosis (aOR=1.69; 1.02-2.83). Conclusions For BC survivors, mental well-being is essential for successful long-term investment in healthy habits. More psychological and dietary support, and a better management of sequelae are needed in this population. Key messages For breast cancer survivors, mental well-being is essential for successful long-term investment in healthy habits. More psychological and dietary support, and better sequelae management are needed to help breast cancer survivors to persist in healthy lifestyle.

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Quality of life among breast cancer survivors treated with breast-conserving therapy in Hawaii.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.31_suppl.154 ◽

2013 ◽

Vol 31 (31_suppl) ◽

pp. 154-154

Author(s):

Francisco A. Conde ◽

Andrea R. Wilburn

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Side Effects ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Well Being ◽

Breast Conserving Therapy ◽

Long Term Survivors

154 Background: Aim of this study was to compare quality of life (QOL), treatment-related side effects, and needs of recent and long-term breast cancer survivors following breast-conserving therapy. Methods: Surveys were sent to 750 women with Tis, T1 – T4 breast tumors without lymph node involvement who received lumpectomy followed by radiotherapy at a large, tertiary care facility in Hawai‘i from January 2001 to December 2010. To assure adequate representation across years, 75 women were randomly selected from each year. Surveys included demographic items, City of Hope Quality of Life – Breast Cancer Instrument, and Breast Cancer Prevention Trial Symptom Scales. Completed surveys were received from 265 (35.3%) women, and findings were analyzed for long-term survivors (diagnosed from 2001-2003, n=76), mid-range survivors (diagnosed from 2004-2007, n=95), and recent survivors (diagnosed from 2008-2010, n=94). Results: Overall, respondents reported high QOL. Similarly to recent breast cancer survivors, long-term survivors reported slight to moderate side effects, including hot flashes, vaginal problems, musculoskeletal pain, and cognitive dysfunction. After controlling for age, ethnicity, and cancer stage, there was no significant differences in QOL physical, psychological, and social well-being subscale scores across time periods. Long-term survivors were more likely than shorter-term survivors to want information regarding nutrition (p<.01), physical activity (p=.018), and ways to restore strength, mobility, and cognition (p<.01). Conclusions: Breast cancer survivors treated with breast conserving therapy report relatively good QOL between 2 and 12 years post-treatment, although they continued to experience physiological issues (which could be exacerbated by age), and anxieties about their cancer. Healthcare professionals should continually assess for ongoing cancer-related side effects even years after completing treatment. Funding: This research was supported by ‘Imi Hale Native Hawaian Cancer Network (U54 CA153459).

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