scholarly journals Comparison of CT Volumetry versus Nuclear Renography for Predicting Remaining Kidney Function After Uninephrectomy in Living Kidney Donors

2021 ◽  
Author(s):  
Sang Hun Eum ◽  
Hanbi Lee ◽  
Eun Jeong Ko ◽  
Hyuk Jin Cho ◽  
Chul Woo Yang ◽  
...  
Keyword(s):  
Kidney Function ◽  
Imaging Modalities ◽  
Kidney Volume ◽  
Ct Volumetry ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Cohort Group ◽  
Total Cohort ◽  
Function Recovery ◽  
Discordant Group

Abstract Computed tomography (CT) and nuclear renography are used to determine kidney procurement in living kidney donors (LKDs). The present study investigated which modality better predicts kidney function after donation. This study included 835 LKDs and they were divided into two subgroups based on whether the left-right dominance of kidney volume was concordant with kidney function (concordant group) or not (discordant group). The predictive value for post-donation kidney function between the two imaging modalities was compared at 1 month, 6 months, and > 1 year in total cohort, concordant, and discordant groups. Split kidney function (SKF) measured by both modalities showed significant correlation with each other at baseline. SKFs of remaining kidney measured using both modalities before donation showed significant correlation with eGFR (estimated glomerular filtration rate) after donation in the total cohort group and two subgroups, respectively. CT volumetry was superior to nuclear renography for predicting post-donation kidney function in the total cohort group and both subgroups. In the discordant subgroup, a higher tendency of kidney function recovery was observed when kidney procurement was determined based on CT volumetry. In conclusion, CT volumetry is preferred when determining procurement strategy especially when discordance is found between the two imaging modalities.

Quantification of Single-Kidney Function and Volume in Living Kidney Donors Using Dynamic Contrast-Enhanced MRI

2016 ◽  
Vol 207 (5) ◽  
pp. 1022-1030 ◽  
Author(s):  
Eli Eikefjord ◽  
Erling Andersen ◽  
Erlend Hodneland ◽  
Einar Svarstad ◽  
Arvid Lundervold ◽  
...  
Keyword(s):  
Kidney Function ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Single Kidney ◽  
Contrast Enhanced Mri

scholarly journals Reduced kidney function in living kidney donors

2007 ◽  
Vol 71 (10) ◽  
pp. 1077 ◽  
Author(s):  
R.K. Wan ◽  
E. Spalding ◽  
D. Winch ◽  
K. Brown ◽  
C.C. Geddes
Keyword(s):  
Kidney Function ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Reduced Kidney Function

Prediabetic Living Kidney Donors Have Preserved Kidney Function at 10 Years After Donation

2014 ◽  
Vol 97 (7) ◽  
pp. 748-754 ◽  
Author(s):  
Sindhu Chandran ◽  
Umesh Masharani ◽  
Allison B. Webber ◽  
David M. Wojciechowski
Keyword(s):  
Kidney Function ◽  
Kidney Donors ◽  
Living Kidney Donors

Comparison of Postdonation Kidney Function Between Caucasian Donors and Low-risk APOL1 Genotype Living Kidney Donors of African Ancestry

2018 ◽  
Vol 102 (11) ◽  
pp. e462-e463 ◽  
Author(s):  
François Gaillard ◽  
Olivier Gribouval ◽  
Marie Courbebaisse ◽  
Catherine Fournier ◽  
Corinne Antignac ◽  
...  
Keyword(s):  
Kidney Function ◽  
African Ancestry ◽  
Low Risk ◽  
Kidney Donors ◽  
Living Kidney Donors

Efficacy of Follow-up Care System of Living Kidney Donors in Monitoring of Residual Kidney Function

2018 ◽  
Vol 50 (6) ◽  
pp. 1590-1596
Author(s):  
M. Kwapisz ◽  
R. Kieszek ◽  
K. Jędrzejko ◽  
M. Bieniasz ◽  
J. Gozdowska ◽  
...  
Keyword(s):  
Kidney Function ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Residual Kidney Function ◽  
Follow Up Care ◽  
Care System

scholarly journals P1663CLINICAL AND PATHOLOGICAL FACTORS INFLUENCING RESIDUAL RENAL FUNCTION AFTER LIVING DONOR NEPHRECTOMY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Akihiro Okubo ◽  
Hideki Yokoi ◽  
Kaoru Sakai ◽  
Takeshi Matsubara ◽  
Motoko Yanagita
Keyword(s):  
Renal Function ◽  
Kidney Transplantation ◽  
University Hospital ◽  
Kidney Volume ◽  
Nephron Number ◽  
Kidney Donors ◽  
Protocol Biopsy ◽  
Living Kidney Donors ◽  
Post Transplant ◽  
Factors Influencing

Abstract Background and Aims Renal function decreases with aging. Aging is associated with significant changes in structure and function of the kidney. On the macrostructural level, kidney cortical volume decreases, therefore total kidney volume (TKV) also decreases with aging. On the microstructural level, the number of glomerulosclerosis increases, therefore nephron number decreases with aging. Some reports show that the decline of TKV and nephron number is accompanied by a reduction in renal function. However, in the field of living kidney transplantation, TKV and glomerulosclerosis are not fully evaluated as factors influencing the donor’s post-transplant renal function. Living kidney transplantation is an established renal replacement therapy for end-stage renal disease patients. To predict living kidney recipient’s renal function, one-hour protocol biopsy is conducted during the operation. From one-hour protocol biopsy, donor’s pathophysiological findings such as glomerulosclerosis can be evaluated. In this study, we evaluated the correlation of potential influencing factors including TKV and glomerulosclerosis with pre- and post-transplant renal function in living kidney donors. Method This is a retrospective study including all 37 living related kidney donors seen at Kyoto University Hospital from January 2013 to April 2019. Estimated glomerular filtration rate (eGFR) was calculated using equation for Japanese population from serum creatinine levels at pre- and post-transplant. TKV was calculated from the 3D volume-rendered images of enhanced CT (=π/6×length×width×thickness), and adjusted to standard body surface area (BSA) by individual BSA. The ratio of number of non-glomerulosclerosis per that of whole glomeruli (non-GS) was evaluated by protocol renal biopsy at one hour after renal reperfusion. This study protocol was approved by the Ethics Committee on human research of the Graduate School of Medicine, Kyoto University. Results We evaluated 37 living kidney donors (35.1% male, mean age 58.2 ± 12.0 years). Mean pre-transplant eGFR was 75.7 ± 12.1 ml/min/1.73m2, mean post-transplant eGFR; 44.9 ± 7.75 ml/min/1.73m2, adjusted TKV (aTKV); 349.3 ± 58.4 ml, and non-GS; 0.892 ± 0.086. Pre-transplant eGFR was associated with aTKV and aTKV×nonGS (r=0.525, 0.569 respectively, p<0.01). Post-transplant eGFR was associated with age (≧65 years old, p<0.01), aTKV, non-GS, and aTKV×non-GS (r=0.527, 0.344, 0.626 respectively, p<0.05). The rate of eGFR decline was associated with age (≧65 years old, p=0.044), but not with aTKV and non-GS, aTKV×non-GS. Conclusion These results suggest that non-GS and age are correlated with post-transplant renal function but not pre-transplant renal function in living kidney donor, and the decline rate of eGFR are correlated with age.

Predictors of Kidney Volume Change and Delayed Kidney Function Recovery After Donor Nephrectomy

2010 ◽  
Vol 184 (3) ◽  
pp. 1057-1063 ◽  
Author(s):  
Hwang Gyun Jeon ◽  
Seung Ryeol Lee ◽  
Dong Jin Joo ◽  
Young Taik Oh ◽  
Myoung Soo Kim ◽  
...  
Keyword(s):  
Kidney Function ◽  
Volume Change ◽  
Donor Nephrectomy ◽  
Kidney Volume ◽  
Function Recovery

scholarly journals The evaluation of kidney function in living kidney donor candidates

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0003052021
Author(s):  
Neetika Garg ◽  
Emilio D. Poggio ◽  
Didier Mandelbrot
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Creatinine Clearance ◽  
Kidney Function ◽  
The United States ◽  
Estimated Gfr ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Increased Risk ◽  
Measured Gfr

Living kidney donors incur a small increased risk of end-stage kidney disease (ESKD), of which pre-donation glomerular filtration rate (GFR) is an important determinant. As a result, kidney function assessment is central to the donor candidate evaluation and selection process. This article reviews the different methods of GFR assessment including estimated GFR, creatinine clearance and measured GFR, and the current guidelines on GFR thresholds for donor acceptance. Estimated GFR obtained using the 2009 Chronic Kidney Disease Epidemiology Collaboration equation, while the best of estimating estimations, tends to underestimate and has limited accuracy, especially near normal GFR values. In the United States, the Organ Procurement and Transplantation Network policy on living donation mandates either measured GFR or creatinine clearance as part of evaluation. Measured GFR is considered the gold standard, although there is some variation in performance characteristics depending on the marker and technique used. Major limitations of creatinine clearance are dependency on accuracy of timed collection, and overestimation as a result of distal tubular creatinine secretion. GFR declines with healthy aging, and most international guidelines recommend use of age-adapted selection criteria. The 2017 Kidney Disease: Improving Global Outcomes Guideline for the Evaluation and Care of Living Kidney Donors diverges from other guidelines and recommends using absolute cut-off of <60 ml/min/1.73m2 for exclusion and of ≥90 ml/min/1.73m2 for acceptance, and determination of candidacy with intermediate GFR based on long-term ESKD risk. However, several concerns for this strategy exist, including inappropriate acceptance of younger candidates due to underestimation of risk, and exclusion of older candidates whose kidney function is in fact appropriate for age. Role of cystatin C and other newer biomarkers, as well as data on impact of pre-donation GFR on not just ESKD risk but also advanced chronic kidney disease risk and cardiovascular outcomes are needed.

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