scholarly journals Robust Metabolomics Approach For The Evaluation Of Human Embryos From In-Vitro Fertilization.

2021 ◽  
Author(s):  
Cecilia Figoli ◽  
Marcelo Garcea ◽  
Claudio Bisioli ◽  
Valeria Tafintseva ◽  
Volha Shapaval ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
In Vitro Fertilization ◽  
Selection Criterion ◽  
Human Embryos ◽  
Spectral Features ◽  
Success Rates ◽  
Vitro Fertilization ◽  
Main Challenge ◽  
Culture Supernatants

Abstract The identification of the most competent embryos for transfer to the uterus constitutes the main challenge of in-vitro fertilization (IVF). We established a metabolomic-based approach applying Fourier Transform Infrared spectroscopy (FTIR) on 130 samples of 3-days embryo culture supernatants from 26 embryos that implanted and 104 that failed. Examining the internal structure of the data by unsupervised multivariate analysis, it was observed that the supernatants of nonimplanted embryos contained highly heterogeneous spectral features. These features were overlapping with metabolic-implantation fingerprints, thus demonstrating that in establishing embryo-assessment models a one-class modelling involving only the samples with positive-implantation outcomes should be applied. Analysis of variance confirmed that the women´s age (>40 years) undermined the implantation of the embryos exhibiting implantation metabolomics, and also that constituted a condition triggering embryos to express nonimplantation metabolomics. We conclude that IVF-success rates can be significantly improved if FTIR spectroscopy is used as an embryo-selection criterion.

scholarly journals A robust metabolomics approach for the evaluation of human embryos from in vitro fertilization

The Analyst ◽  
2021 ◽  
Vol 146 (20) ◽  
pp. 6156-6169
Author(s):  
Cecilia Beatriz Figoli ◽  
Marcelo Garcea ◽  
Claudio Bisioli ◽  
Valeria Tafintseva ◽  
Volha Shapaval ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ftir Spectroscopy ◽  
Human Embryos ◽  
Success Rates ◽  
Vitro Fertilization

When establishing embryo-assessment models, only those samples with positive-implantation outcomes should be applied. By this strategy, a noninvasive FTIR-spectroscopy-based method that will be helpful for improving IVF success rates was developed.

Professional Self-Regulation and Shared-Risk Programs for In Vitro Fertilization

1997 ◽  
Vol 25 (4) ◽  
pp. 283-291 ◽  
Author(s):  
John A. Robertson ◽  
Theodore J. Schneyer
Keyword(s):  
In Vitro Fertilization ◽  
Success Rate ◽  
Legal Status ◽  
Self Regulation ◽  
The United States ◽  
Human Embryos ◽  
Success Rates ◽  
Vitro Fertilization ◽  
Shared Risk

In vitro fertilization (IVF) is now a well-established practice in the field of assisted reproduction. In 1995, over 41,000 IVF cycles were done in the United States, at a cost of more than $300 million. The overall success rate has risen to 22.8 deliveries per 100 egg-retrieval procedures (19.6 deliveries per initiated cycle). As the field has matured, the attention of policy-makers has shifted from questions about the ethical and legal status of human embryos to concerns about providing access and protecting consumers.Three such concerns have emerged. One is the danger that IVF programs will disseminate misleading information about their success rates in order to attract patients. This problem, however, may be alleviated by the publication in late 1997 of the first of annual national and clinic specific reports, based on randomly audited data, by the Centers for Disease Control and Prevention, the American Society of Reproductive Medicine (ASRM), the Society for Assisted Reproductive Technology (SART), and RESOLVE, pursuant to the federal 1992 Fertility Clinic Success Rate and Laboratory Certification Act.

Doing Wrong to ‘Lulu’ and ‘Nana’? Applying Parfit to the He Jiankui Experiment

2020 ◽  
Vol 34 (1) ◽  
pp. 157-170
Author(s):  
Norman K. Swazo ◽  
Keyword(s):  
Clinical Trial ◽  
In Vitro Fertilization ◽  
Research Team ◽  
Gene Editing ◽  
Genomic Research ◽  
Human Embryos ◽  
Derek Parfit ◽  
Identity Problem ◽  
Vitro Fertilization

In November 2018, Dr. He Jiankui announced the birth of two baby girls born through the use of in vitro fertilization technology and the use of the gene-editing tool CRISPR-Cas9. There has been nigh uniform international condemnation of the clinical trial for violating international norms governing genomic research, especially research in human embryos that has implications for the germline. At issue also is the question whether the parents and the clinical research team harmed, and therefore wronged, the two girls. Here this question is engaged through application of the reasoning Derek Parfit has provided on the non-identity problem. One concludes that on this reasoning the parents are not morally culpable on that argument, although there is other reasoning that is to be considered to resist the Parfitian conclusion.

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