scholarly journals SARS-CoV-2 Preimmune IgM Epitopes

2020 ◽  
Author(s):  
Velizar Shivarov ◽  
Peter Petrov ◽  
Anastas Pashov
Keyword(s):  
Fast Track ◽  
Vaccine Development ◽  
Open Reading Frame ◽  
Spike Protein ◽  
Reading Frame

Abstract While studying the human public IgM igome as represented by a library of 224087 linear mimotopes, three exact matches to peptides in the proteins of SARS-CoV-2 were found: two in the open reading frame 1ab and one in the spike protein. Joining the efforts to fast track SARS-CoV-2 vaccine development, here we describe briefly these potential epitopes in comparison to mimotopes representing peptides of SARS-CoV , HCoV 229E and OC43.

scholarly journals Immunoinformatics Patterns and Characteristic of Epitope-Based Peptide Vaccine candidates against COVID-19

2020 ◽  
Author(s):  
Mujahed I. Mustafa ◽  
Abdelrahman H. Abdelmoneim ◽  
Abdelrafie M. Makhawi
Keyword(s):  
Vaccine Development ◽  
Peptide Vaccine ◽  
Infectious Agent ◽  
Spike Protein ◽  
Reading Frame ◽  
Vaccine Candidates ◽  
Human Genome Sequencing ◽  
The Difference ◽  
Immunogenic Proteins ◽  
Selection Of

Vaccination as defined by the WHO is “the administration of agent-specific, but safe, antigenic components that in vaccinated individuals can induce protective immunity against the corresponding infectious agent”. Regardless of their debated history, the standard vaccine approaches have been unsuccessful in providing vaccines for numerous infectious organisms. In the recent three decades, an enormous amount of immunological data was retrieved from clinical studies  due to the advancement in human genome sequencing. These data are being deposited in databases and numerous scientific literature. The development of several bioinformatics tools to analyze this rapidly increasing immunological databank has given rise to the field of immunoinformatics. This approach allows the selection of immunogenic residues from the pathogen genomes. The ideal residues could be industrialized as vaccine candidates to provide protective immune responses in the hosts. This methodology will significantly decrease the time and cost needed for the vaccine development.  This review focus on  published articles that proposed as vaccine candidates through immunoinformatics analysis. The reviewed  Published immunoinformatics studies provided vaccine peptide candidates against SARS-COV-2, which is based on functional and non functional immunogenic proteins like open reading frame , spike protein, envelope protein and membranous protein .All of which  are designed by unique strategies like reverse vaccinology . Spike protein was the most common used target with different suggeststed B and T cell peptides  due to the difference in methodology between the findings.

scholarly journals The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame

1991 ◽  
Vol 266 (16) ◽  
pp. 10050-10053
Author(s):  
K.E. Hill ◽  
R.S. Lloyd ◽  
J.G. Yang ◽  
R. Read ◽  
R.F. Burk
Keyword(s):  
Open Reading Frame ◽  
Selenoprotein P ◽  
Reading Frame
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