scholarly journals Risk Factors for Sub–therapeutic Serum Concentrations of Magnesium Sulfate in Severe Preeclampsia of Chinese Patients

2020 ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Maintenance Dose ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Roc Curve Analysis ◽  
Serum Magnesium Concentration

Abstract Background: Magnesium sulfate (MgSO 4 ) is the standard drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. There is little information on how to achieve and maintain effective therapeutic concentrations. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO 4 in patients with severe preeclampsia. Methods: Patients with severe preeclampsia who received MgSO 4 intravenous infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO 4 , and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration. Results: A total of 93 patients with severe preeclampsia were included in the study. 52 (55.91%) patients did not attain therapeutic serum magnesium levels. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time interval from measurement of blood magnesium concentration to the beginning of maintenance dose administration) as independent risk factors for sub - therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in a cutoff point of 132.82 mL/min; while measurement time had limited predictive value, with cutoff point of 2.375 h. Conclusions: Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub - therapeutic serum magnesium concentration. A loading dose of MgSO 4 everytime before the maintenance dose, as well as an infusion time of more than 2.375 hours for MgSO 4 maintenance dose are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE whose Ccr is ≥ 132.82 mL/min.

scholarly journals Risk Factors for Sub–therapeutic Serum Concentrations of Magnesium Sulfate in Severe Preeclampsia of Chinese Patients

2020 ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Roc Curve Analysis ◽  
Serum Magnesium Concentration ◽  
Independent Risk Factors

Abstract Background: Magnesium sulfate (MgSO4) is the standard drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. There is little information on how to achieve and maintain effective therapeutic concentrations. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO4 in patients with severe preeclampsia. Methods: Patients with severe preeclampsia who received MgSO4 intravenous infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO4, and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration. Results: A total of 93 patients with severe preeclampsia were included in the study. 52 (55.91%) patients did not attain therapeutic serum magnesium levels. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time from start of MgSO4 infusion to blood draw for serum sampling) as independent risk factors for sub-therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in a cutoff point of 133 mL/min; while measurement time had limited predictive value, with cutoff point of 2.375 h. Conclusions: Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub-therapeutic serum magnesium concentration. A loading dose of MgSO4 everytime before the maintenance dose, as well as the duration of MgSO4 maintenance dose of more than 2.375 hours are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE and whose Ccr is ≥ 133 mL/min.

scholarly journals Risk Factors for Sub–therapeutic Serum Concentrations of Magnesium Sulfate in Severe Preeclampsia of Chinese Patients

2020 ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Roc Curve Analysis ◽  
Serum Magnesium Concentration ◽  
Independent Risk Factors

Abstract Background: Magnesium sulfate (MgSO4) is the standard drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. There is little information on how to achieve and maintain effective therapeutic concentrations. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO4 in patients with severe preeclampsia. Methods: Patients with severe preeclampsia who received MgSO4 intravenous infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO4, and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration. Results: A total of 93 patients with severe preeclampsia were included in the study. 52 (55.91%) patients did not attain therapeutic serum magnesium levels. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time from start of MgSO4 infusion to blood draw for serum sampling) as independent risk factors for sub-therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in a cutoff point of 133 mL/min; while measurement time had limited predictive value, with cutoff point of 2.375 h. Conclusions: Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub-therapeutic serum magnesium concentration. A loading dose of MgSO4 everytime before the maintenance dose, as well as the duration of MgSO4 maintenance dose of more than 2.375 hours are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE and whose Ccr is ≥ 133 mL/min.

scholarly journals Risk factors for sub–therapeutic serum concentrations of magnesium sulfate in severe preeclampsia of Chinese patients

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Roc Curve Analysis ◽  
Serum Magnesium Concentration ◽  
Independent Risk Factors

Abstract Background Magnesium sulfate (MgSO4) is the standard drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. There is little information on how to achieve and maintain effective therapeutic concentrations. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO4 in patients with severe preeclampsia. Methods Patients with severe preeclampsia who received MgSO4 intravenous infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO4, and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration. Results A total of 93 patients with severe preeclampsia were included in the study. 52 (55.91%) patients did not attain therapeutic serum magnesium levels. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time from start of MgSO4 infusion to blood draw for serum sampling) as independent risk factors for sub-therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in a cutoff point of 133 mL/min; while measurement time had limited predictive value, with cutoff point of 2.375 h. Conclusions Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub-therapeutic serum magnesium concentration. A loading dose of MgSO4 everytime before the maintenance dose, as well as the duration of MgSO4 maintenance dose of more than 2.375 h are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE and whose Ccr is ≥133 mL/min.

scholarly journals Risk Factors for Sub–therapeutic Serum Concentrations of Magnesium Sulfate in Severe Preeclampsia of Chinese Patients

2020 ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Roc Curve ◽  
Maintenance Dose ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Serum Magnesium Concentration

Abstract Background: Magnesium sulfate (MgSO4) is the ideal drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. Although there have been individual reports on the use of MgSO4 in pregnant women with severe preeclampsia, there is little information on how to achieve and maintain effective therapeutic concentrations in China. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO4 in patients with severe preeclampsia.Methods: Patients with severe preeclampsia who received MgSO4 intravenous (IV) infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO4, and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration.Results: A total of 93 patients with severe preeclampsia were included in the study. There were 41 (44.09%) patients attained therapeutic serum magnesium levels and 52 (55.91%) patients did not. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time interval from measurement of blood magnesium concentration to the beginning of maintenance dose administration) as independent risk factors for sub-therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in the area under ROC curve of 0.715 and a cutoff point of 132.82 mL/min, while measurement time had limited predictive value, with the area under ROC curve of 0.650 and cutoff point of 2.375 h.Conclusions: Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub-therapeutic serum magnesium concentration. A loading dose of MgSO4 everytime before the maintenance dose, as well as an infusion time of more than 2.375 hours for MgSO4 maintenance dose are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE and whose Ccr is ≥ 132.82 mL/min.

scholarly journals Risk Factors for Sub–therapeutic Serum Concentrations of Magnesium Sulfate in Severe Preeclampsia of Chinese Patients

2020 ◽  
Author(s):  
Jingjing Li ◽  
Lian Tang ◽  
Ruiheng Tang ◽  
Lan Peng ◽  
Liqiang Chai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Magnesium ◽  
Multivariate Logistic Regression Analysis ◽  
Severe Preeclampsia ◽  
Measurement Time ◽  
Magnesium Concentration ◽  
Loading Dose ◽  
Roc Curve Analysis ◽  
Serum Magnesium Concentration ◽  
Independent Risk Factors

Abstract Background: Magnesium sulfate (MgSO4) is the standard drug for eclampsia prophylaxis and treatment. In China, the effective therapeutic serum magnesium level is 1.8–3.0 mmol/L. There is little information on how to achieve and maintain effective therapeutic concentrations. This study aimed to investigate risk factors for sub-therapeutic serum concentrations of MgSO4 in patients with severe preeclampsia. Methods: Patients with severe preeclampsia who received MgSO4 intravenous infusion were retrospectively reviewed. The maternal demographic characteristics, regimens for the administration of MgSO4, and lab test results of patients were collected. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were conducted for the risk factors influencing the serum magnesium concentration. Results: A total of 93 patients with severe preeclampsia were included in the study. 52 (55.91%) patients did not attain therapeutic serum magnesium levels. A multivariate logistic regression analysis identified creatinine clearance (Ccr), whether the loading dose was given, and measurement time of serum magnesium concentration (referring to the time from start of MgSO4 infusion to blood draw for serum sampling) as independent risk factors for sub-therapeutic serum magnesium concentration (P < 0.05). ROC curve analysis indicated that the continuous variable Ccr had a significant predictive value for the serum magnesium concentration, which resulted in a cutoff point of 133 mL/min; while measurement time had limited predictive value, with cutoff point of 2.375 h. Conclusions: Ccr, whether the loading dose was given, and measurement time were independent risk factors for sub-therapeutic serum magnesium concentration. A loading dose of MgSO4 everytime before the maintenance dose, as well as the duration of MgSO4 maintenance dose of more than 2.375 hours are recommended for all the patients with severe PE. Routine evaluation of serum magnesium levels is a recommended practice for women with severe PE and whose Ccr is ≥ 133 mL/min.

Maternal magnesium therapy, neonatal serum magnesium concentration and immediate neonatal outcomes

2017 ◽  
Vol 37 (12) ◽  
pp. 1297-1303 ◽  
Author(s):  
D Narasimhulu ◽  
A Brown ◽  
N M Egbert ◽  
M Rojas ◽  
S Haberman ◽  
...  
Keyword(s):  
Serum Magnesium ◽  
Neonatal Outcomes ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration ◽  
Magnesium Therapy

53: Serum Magnesium Concentration After Magnesium Citrate Bowel Preparation

2010 ◽  
Vol 55 (4) ◽  
pp. B45
Author(s):  
Nisha Bhatt ◽  
George Bayliss ◽  
M. Rachel Sim ◽  
Suzanne Martin ◽  
Jacqueline Wolf ◽  
...  
Keyword(s):  
Bowel Preparation ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Magnesium Citrate ◽  
Serum Magnesium Concentration

Total serum magnesium in cats with chronic kidney disease with nephrolithiasis

2019 ◽  
Vol 21 (12) ◽  
pp. 1172-1180 ◽  
Author(s):  
Fernanda Chicharo Chacar ◽  
Marcia Mery Kogika ◽  
Andréa C Ferreira ◽  
Khadine K Kanayama ◽  
Archivaldo Reche
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Magnesium ◽  
Magnesium Concentration ◽  
Total Serum ◽  
Serum Magnesium Concentration ◽  
Electrolyte Disturbances ◽  
Kaplan Meier ◽  
Ckd Stage ◽  
Stage 1

ObjectivesMagnesium has been ‘the forgotten ion’ for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. The purpose of this study was to investigate whether CKD cats with nephrolithiasis have changes in total serum magnesium concentrations, and whether magnesium disorders may be associated with other electrolyte disturbances, as well as with prognosis. We also aimed to evaluate whether total serum magnesium concentration differs between CKD cats with and without nephrolithiasis.MethodsTotal serum magnesium concentrations were assessed in 42 cats with CKD with stage 1–4 nephrolithiasis. The correlation between magnesium and other electrolytes, as well as Kaplan–Meier survival analysis, were performed. We also selected 14 control cats with CKD without nephrolithiasis age-matched with 14 cats with CKD with nephrolithiasis.ResultsHypermagnesemia was observed in 16/42 (38.1%) and hypomagnesemia in 6/42 (14.3%) cats. Serum magnesium abnormalities were observed in cats of all stages, and marked hypermagnesemia was noted in cats with stage 4 CKD with nephrolithiasis ( P <0.001). There was a negative correlation between total serum magnesium and ionized calcium ( r = −0.64; P <0.01), and a positive correlation between total serum magnesium and serum phosphorus ( r = 0.58, P = 0.01). Cats with CKD with nephrolithiasis and hypomagnesemia or hypermagnesemia had higher mortality than those with normal total serum magnesium concentration ( P <0.01), regardless of CKD stage. There was no difference in total serum magnesium concentration between CKD cats with and without nephrolithiasis.Conclusions and relevanceCats with CKD with nephrolithiasis have magnesium abnormalities. Hypomagnesemia and hypermagnesemia were associated with an increase in mortality, and thus total serum magnesium abnormalities may be used as prognostic factors in these cases.

scholarly journals Serum Magnesium Concentration Is Inversely Associated with Albuminuria and Retinopathy among Patients with Diabetes

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Lu ◽  
Yuying Gu ◽  
Meixiang Guo ◽  
Peihong Chen ◽  
Hongtao Wang ◽  
...  
Keyword(s):  
Microvascular Complications ◽  
Serum Magnesium ◽  
Multiple Logistic Regression Analysis ◽  
Albumin Excretion Rate ◽  
Normal Serum ◽  
Fundus Photography ◽  
Magnesium Concentration ◽  
Serum Magnesium Concentration ◽  
Patients With Diabetes ◽  
Diabetic Microvascular Complications

Aim. To investigate the association between serum magnesium levels and microvascular complications among patients with diabetes.Methods. Patients with diabetes were recruited between April 2012 and January 2015. All patients received an assay of serum magnesium concentration, were screened for 24 h albumin excretion rate, and underwent nonmydriatic fundus photography. Albuminuria and retinopathy were defined accordingly. A total of 3,100 patients with normal serum magnesium levels were included in this study.Results. Patients with albuminuria and/or retinopathy had lower levels of serum magnesium than patients without these complications (P<0.001). The prevalence of isolated albuminuria, isolated retinopathy, and combined albuminuria and retinopathy decreased as the concentration of serum magnesium increased. Multiple logistic regression analysis indicated that the odds ratio for isolated albuminuria, isolated retinopathy, and concomitant albuminuria and retinopathy decreased by approximately 20% for every 0.1 mmol/L increase in serum magnesium concentration.Conclusion. Serum magnesium levels were negatively associated with the risk of diabetic microvascular complications among patients with serum magnesium levels within the normal range.

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