Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

Abstract Background: To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. Methods: This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. Results: According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. Conclusions: Metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v3 ◽

2020 ◽

Author(s):

Mohd Razif Shahril ◽

Syed Amirfaiz ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

East Coast ◽

Fasting Blood Glucose ◽

Peninsular Malaysia ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

Abstract To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. In conclusion, metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v2 ◽

2020 ◽

Author(s):

Mohd Razif Shahril ◽

Syed Amirfaiz ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

East Coast ◽

Fasting Blood Glucose ◽

Peninsular Malaysia ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

Abstract To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. In conclusion, metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v1 ◽

2020 ◽

Author(s):

Syed Amirfaiz ◽

Mohd Razif Shahril ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Cancer Survivors ◽

Body Fat ◽

Breast Cancer Survivors ◽

East Coast ◽

Peninsular Malaysia ◽

Body Fat Percentage ◽

Fat Percentage

Abstract To date, limited data are available on metabolic syndrome (MetS) prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of MetS and abnormal MetS components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the MetS prevalence was 50.5%. Among those with MetS, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other MetS components were significantly different (p<0.05) between those with and without MetS. Significant differences between MetS and non-MetS groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). Otherwise, no significant difference was reported in other sociodemographic and clinical parameters between cancer survivors with and without MetS. In conclusion, MetS was highly prevalent among breast cancer survivors in this study, with weight, BMI, waist circumference, body fat percentage and cancer stages significantly affect MetS status.

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Factors Affecting Onset and Persistence of Metabolic Syndrome in Korean Breast Cancer Survivors: A Prospective Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186814 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6814

Author(s):

Suyoun Maeng ◽

Jungok Yu

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Cancer Survivors ◽

Health Care Providers ◽

Urban Areas ◽

Breast Cancer Survivors ◽

Health Examination ◽

Care Providers ◽

The Metabolic Syndrome

This study aimed to investigate the onset and persistence of metabolic syndrome in breast cancer survivors in a community setting. The study included 329 female breast cancer survivors from 39 community health examination centers located in 14 urban areas in Korea. After an average of 4.6 years of follow-up, based on the presence of metabolic syndrome at baseline and follow-up, the subjects were assigned to three groups: Non-metabolic syndrome (n = 249), onset (n = 32), and persistent (n = 48). Factors associated with the metabolic syndrome were analyzed and presented as odds ratios (ORs). Older age, postmenopausal status, lower education, and lower-income level were associated with an increased prevalence of metabolic syndrome in the onset Mets and persistent Mets group. In particular, when the breast cancer survivor was obese (≥25 kg/m2), the probability of developing metabolic syndrome was 3.33 times higher than normal-weight subjects (<23 kg/m2) and the probability of metabolic syndrome persisting was 16.34 times. When breast cancer survivors were in their 60s or older, the probability of metabolic syndrome persisting was 4.27 times higher than those in their 40s. To prevent the onset and persistence of metabolic syndrome in breast cancer survivors, health-care providers should identify risk factors. Obesity, in particular, should be controlled.

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Abstract B10: Fasting blood glucose and bone mineral density in Latina breast cancer survivors

10.1158/1940-6215.prev-14-b10 ◽

2015 ◽

Author(s):

Christina Dieli-Conwright ◽

Lindsey Avery ◽

Joanne Mortimer ◽

Debu Tripathy ◽

Darcy Spicer ◽

...

Keyword(s):

Breast Cancer ◽

Bone Mineral Density ◽

Blood Glucose ◽

Cancer Survivors ◽

Bone Mineral ◽

Breast Cancer Survivors ◽

Fasting Blood Glucose ◽

Mineral Density

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The metabolic syndrome in healthy, multiethnic adolescents in Toronto, Ontario: The use of fasting blood glucose as a simple indicator

Canadian Journal of Cardiology ◽

10.1016/s0828-282x(10)70360-3 ◽

2010 ◽

Vol 26 (3) ◽

pp. e128-e132 ◽

Cited By ~ 6

Author(s):

Vladimir Vuksan ◽

Valentina Peeva ◽

Alexander Rogovik ◽

Uljana Beljan-Zdravkovic ◽

Mark Stavro ◽

...

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

The Metabolic Syndrome ◽

Simple Indicator

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Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.90368.2008 ◽

2009 ◽

Vol 296 (1) ◽

pp. E203-E210 ◽

Cited By ~ 13

Author(s):

Michele La Merrill ◽

David S. Baston ◽

Michael S. Denison ◽

Linda S. Birnbaum ◽

Daniel Pomp ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

Blood Glucose ◽

Estrogenic Activity ◽

Fasting Blood Glucose ◽

Growth Spurt ◽

Cancer Model ◽

Serum Triglycerides ◽

Cancer Models

Diets high in fat are associated with increased susceptibility to obesity and metabolic syndrome. Increased adipose tissue that is caused by high-fat diets (HFD) results in altered storage of lipophilic toxicants like 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), which may further increase susceptibility to metabolic syndrome. Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz[a]anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background. Pregnant mice dosed with 1 μg/kg of TCDD or vehicle on gestational day 12.5 were placed on a HFD or low-fat diet (LFD) at parturition. Body weights, percent body fat, and fasting blood glucose were measured longitudinally, and triglycerides were measured at study termination. On HFD, all cancer models reached the pubertal growth spurt ahead of FVB controls. Among mice fed HFD, the HER2 model had a greater increase in body weight and adipose tissue from puberty through adulthood compared with the PyMT and DMBA models. However, the DMBA model consistently had higher fasting blood glucose levels than the PyMT and HER2 models. TCDD only impacted serum triglycerides in the PyMT model maintained on HFD. Because the estrogenic activity of the HFD was three times lower than that of the LFD, differential dietary estrogenic activities did not drive the observed phenotypic differences. Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise.

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