Linking fasting blood glucose quartiles of nondiabetic volunteers ages 21–84 years to metabolic syndrome components: focusing on the aging paradox

Abstract Background: To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. Methods: This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. Results: According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. Conclusions: Metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v4 ◽

2020 ◽

Author(s):

Mohd Razif Shahril ◽

Syed Amirfaiz ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

East Coast ◽

Fasting Blood Glucose ◽

Peninsular Malaysia ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

Abstract To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. In conclusion, metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v3 ◽

2020 ◽

Author(s):

Mohd Razif Shahril ◽

Syed Amirfaiz ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

East Coast ◽

Fasting Blood Glucose ◽

Peninsular Malaysia ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

Abstract To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. In conclusion, metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

10.21203/rs.3.rs-22221/v2 ◽

2020 ◽

Author(s):

Mohd Razif Shahril ◽

Syed Amirfaiz ◽

Pei Lin Lua ◽

Ali Nurnazahiah ◽

Nor Syamimi Zakarai ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

East Coast ◽

Fasting Blood Glucose ◽

Peninsular Malaysia ◽

The Metabolic Syndrome ◽

Metabolic Syndrome Components

Abstract To date, limited data are available on metabolic syndrome prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of metabolic syndrome and abnormal metabolic syndrome components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the metabolic syndrome prevalence was 50.5%. Among those with metabolic syndrome, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other metabolic syndrome components were significantly different (p<0.05) between those with and without metabolic syndrome. Significant differences between metabolic syndrome and non-metabolic syndrome groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). However, no significant relationship was reported between sociodemographic, clinical parameters and metabolic syndrome among breast cancer survivors in this study. In conclusion, metabolic syndrome was highly prevalent among breast cancer survivors. It is recommended for health care professionals to closely monitor and improve the triglycerides, blood glucose and HDL-c level of the breast cancer survivors under their care to control the detrimental effect of metabolic syndrome.

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The metabolic syndrome in healthy, multiethnic adolescents in Toronto, Ontario: The use of fasting blood glucose as a simple indicator

Canadian Journal of Cardiology ◽

10.1016/s0828-282x(10)70360-3 ◽

2010 ◽

Vol 26 (3) ◽

pp. e128-e132 ◽

Cited By ~ 6

Author(s):

Vladimir Vuksan ◽

Valentina Peeva ◽

Alexander Rogovik ◽

Uljana Beljan-Zdravkovic ◽

Mark Stavro ◽

...

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

The Metabolic Syndrome ◽

Simple Indicator

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Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.90368.2008 ◽

2009 ◽

Vol 296 (1) ◽

pp. E203-E210 ◽

Cited By ~ 13

Author(s):

Michele La Merrill ◽

David S. Baston ◽

Michael S. Denison ◽

Linda S. Birnbaum ◽

Daniel Pomp ◽

...

Keyword(s):

Breast Cancer ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

Blood Glucose ◽

Estrogenic Activity ◽

Fasting Blood Glucose ◽

Growth Spurt ◽

Cancer Model ◽

Serum Triglycerides ◽

Cancer Models

Diets high in fat are associated with increased susceptibility to obesity and metabolic syndrome. Increased adipose tissue that is caused by high-fat diets (HFD) results in altered storage of lipophilic toxicants like 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), which may further increase susceptibility to metabolic syndrome. Because both TCDD and HFD are associated with increased breast cancer risk, we examined their effects on metabolic syndrome-associated phenotypes in three mouse models of breast cancer: 7,12-dimethylbenz[a]anthracene (DMBA), Tg(MMTV-Neu)202Mul/J (HER2), and TgN(MMTV-PyMT)634Mul/J (PyMT), all on an FVB/N genetic background. Pregnant mice dosed with 1 μg/kg of TCDD or vehicle on gestational day 12.5 were placed on a HFD or low-fat diet (LFD) at parturition. Body weights, percent body fat, and fasting blood glucose were measured longitudinally, and triglycerides were measured at study termination. On HFD, all cancer models reached the pubertal growth spurt ahead of FVB controls. Among mice fed HFD, the HER2 model had a greater increase in body weight and adipose tissue from puberty through adulthood compared with the PyMT and DMBA models. However, the DMBA model consistently had higher fasting blood glucose levels than the PyMT and HER2 models. TCDD only impacted serum triglycerides in the PyMT model maintained on HFD. Because the estrogenic activity of the HFD was three times lower than that of the LFD, differential dietary estrogenic activities did not drive the observed phenotypic differences. Rather, the HFD-dependent changes were cancer model dependent. These results show that cancer models can have differential effects on metabolic syndrome-associated phenotypes even before cancers arise.

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Prevalence of Metabolic Syndrome in Adults in Yazd 2014-2015: Results of Yazd Health Study (Yahs)

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v27i11.2499 ◽

2020 ◽

Author(s):

Vida Mozaffari-Khosravi ◽

Masoud Mirzaei ◽

Hassan Mozaffari-Khosravi

Keyword(s):

Metabolic Syndrome ◽

Blood Glucose ◽

Central Obesity ◽

Fasting Blood Glucose ◽

Health Study ◽

Postal Code ◽

General Obesity ◽

Blood Samples ◽

Blood Tests ◽

Over 40 Years

Introduction: Metabolic syndrome is a series of disorders such as central obesity, hypertriglyceridemia, decreasing HDL, abnormal blood glucose and hypertension that ultimately lead to the risk of cardiovascular disease, diabetes and other problems. The aim of this study was to determine the prevalence of this syndrome among adults in Yazd. Methods: This study was performed using the data of the recruitment phase of "Yazd Health Study" (YaHS). More than 10,000 residents (aged 20-69 years) of Yazd Greater Area have participated in this prospective cohort study. Lifestyle data, disease history, and blood tests have been recorded. Sampling was cluster random based on the postal code of the residents of Yazd Greater Area. Out of the 10,000 participants in the study, approximately 4,000 people gave blood samples to the lab in the first phase and their data were used to calculate the syndrome. Metabolic syndrome was defined based on the ATP III criteria. Data were analyzed by SPSS Version 16. Results: The overall prevalence of syndrome was 33.3%. The prevalence had a significant relationship with age, age over 40 years, reaching to the highest level of over 50%. The prevalence in women was 39.9%, more than men, with 25.9%. Frequency of abnormal components of the syndrome was respectively waist circumference or abdominal obesity (47.1%), diastolic or systolic blood pressure (43.7%), triglyceride (41.6%), HDL (39.5%) and fasting blood glucose (21.7). 67.5% and 91.7% of those with syndrome were obese or overweight, respectively. Conclusion: The study showed that the prevalence of metabolic syndrome, especially in women and those over 50 years old, is higher than other studies. General obesity, central obesity and hypertension are the most important components of metabolic syndrome in Yazd, which requires proper interventions.

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The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

Nutrients ◽

10.3390/nu14010175 ◽

2021 ◽

Vol 14 (1) ◽

pp. 175

Author(s):

Dana Hasan Alkhatib ◽

Abdul Jaleel ◽

Maryam Naveed Muhammad Tariq ◽

Jack Feehan ◽

Vasso Apostolopoulos ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Blood Glucose ◽

Dietary Supplements ◽

Bioactive Compounds ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Preventive Measure ◽

Blood Lipid ◽

Lifestyle Changes

Metabolic syndrome (MetS) is a combination of physiologically dysregulated parameters that can include elevated fasting blood glucose, high blood pressure, central obesity, increased triglyceride levels, insulin resistance, diabetes, elevated low density lipoprotein levels, and reduced high density lipoprotein levels in the blood. Effective clinical management of MetS is critical as it is strongly associated with long lasting and fatal complications in patients. Alongside standard care of lifestyle changes and medication, dietary supplements derived from herbal resources could be an alternative therapeutic strategy that is safe, efficient, culturally acceptable, and has few side effects. Of the dietary supplements, spicy foods have always been considered a great source of functional bioactive compounds. Herbal therapy is broadly used in many countries as a treatment or as a preventive measure in the management of MetS risk factors, including blood glucose, blood pressure, and blood lipid levels. Herein, an attempt is made to evaluate the recent studies in the management of MetS with herbal alternatives, and to explore the possibility of their use as therapeutic treatments or supplements.

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Metabolic characteristics and nutrition intake on women with normal body mass index

Food Research ◽

10.26656/fr.2017.4(s3).s13 ◽

2020 ◽

Vol 4 (S3) ◽

pp. 6-12

Author(s):

D.Y. Fitranti ◽

F.F. Dieny ◽

D.M. Kurniawati ◽

R. Purwanti ◽

B. Kusumaningnastiti ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Hdl Cholesterol ◽

Normal Weight ◽

Normal Body Mass Index ◽

Metabolic Characteristics ◽

Low Hdl ◽

Nutrition Intake

Metabolic syndrome can be found on an individual with normal weight (Metabolically Obese Normal Weight/MONW). Eating habits and lifestyle changing in early adulthood can be the risk of metabolic syndrome in person with a normal body mass index (BMI). The purpose of this study was to identify metabolic characteristics in women with normal BMI and to analyze the correlation of nutrition intake with metabolic syndrome on women with normal BMI. This is an observational study with a cross-sectional design at five offices in Semarang. The sample in this study was 64 subjects. Inclusion criteria of study subject were women aged 25-40 years and BMI <25 kg/m2 . Study subject was chosen by using a consecutive sampling method. The data of nutrition intake was obtained by using the Food Frequency Questionnaire. HDL cholesterol, fasting blood glucose and triglyceride were analyzed. Analysis data was conducted by using Pearson correlation and Rank Spearman. MONW was present in 10.9% and more than 50% had pre metabolic syndrome. A total of 51.6% of the subjects had central obese and 26.6% had low HDL cholesterol. About 14.1% of the subjects have hypertension. There was a positive correlation between energy, fat intake and waist circumference. Carbohydrate intake was positively correlated with fasting blood glucose and triglyceride. The higher protein intake, the higher HDL cholesterol. The most common indicator of metabolic syndrome on women with normal BMI was central obesity and low HDL cholesterol. The factors related to the prevalence of metabolic syndrome on women with normal BMI was macronutrient intake.

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Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults

Journal of Diabetes Research ◽

10.1155/2019/3175418 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Li Li ◽

Qifa Song ◽

Xi Yang

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Blood Glucose ◽

Serum Uric Acid ◽

Muscle Mass ◽

Alanine Aminotransferase ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Elevated Serum ◽

Chinese Adults

The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m2 BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P<0.01) for age, positive associations (P<0.01) for BMI, muscle mass, alanine aminotransferase, and creatinine. The stepwise multivariate logistic regression proved similar associations for age, BMI, creatinine, and alanine aminotransferase. No significant associations were testified between serum uric acid levels and cholesterol, HDL-C, LDL-C, triglyceride, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, and urine microalbumin. Factor analysis illustrated that 15 attributes could be grouped into two common factors and five individual factors. A common underlying factor was identified among uric acid, muscle mass, creatinine, alanine aminotransferase, and BMI. The results indicate that serum uric acid has no apparent association with metabolic syndromes that are commonly characterized by hypertension, dyslipidemia, and T2DM.

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