Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

Abstract Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods: Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile. Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR=1.55, 95% CI: 1.03-2.33). Similar results were also observed for vitamin B6 (OR=1.63, 95% CI: 1.08-2.46), vitamin C (OR=1.59, 95% CI: 1.05-2.42), niacin (OR=1.65, 95% CI: 1.08-2.51), and vitamin K (second versus fourth quartile: OR=1.60, 95% CI: 1.05-2.44).Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer.Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study

Nutrition & Metabolism ◽

10.1186/s12986-020-00521-4 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile. Results The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI 1.08–2.46), vitamin C (OR = 1.59, 95% CI 1.05–2.42), niacin (OR = 1.65, 95% CI 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI 1.05–2.44). Conclusions Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (https://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v1 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China.Methods Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile.Results The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2 + risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI: 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI: 1.08–2.46), vitamin C (OR = 1.59, 95% CI: 1.05–2.42), niacin (OR = 1.65, 95% CI: 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI: 1.05–2.44).Conclusions Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2 + risk. Nutrients may influence the development of higher grade CIN and cervical cancer.Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v3 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods: Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile. Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR=1.55, 95% CI: 1.03-2.33). Similar results were also observed for vitamin B6 (OR=1.63, 95% CI: 1.08-2.46), vitamin C (OR=1.59, 95% CI: 1.05-2.42), niacin (OR=1.65, 95% CI: 1.08-2.51), and vitamin K (second versus fourth quartile: OR=1.60, 95% CI: 1.05-2.44). Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v4 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

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Comparison of a food frequency questionnaire using reported vs standard portion sizes for classifying individuals according to nutrient intake

Journal of the American Dietetic Association ◽

10.1016/s0002-8223(21)01115-9 ◽

1991 ◽

Vol 91 (3) ◽

pp. 316-320 ◽

Cited By ~ 1

Author(s):

Julie A. Clapp ◽

R. Sue McPherson ◽

Debra B. Reed ◽

Bartholomew P. Hsi

Keyword(s):

Food Frequency Questionnaire ◽

Nutrient Intake ◽

Food Frequency ◽

Portion Sizes

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Validation of a Food Frequency Questionnaire Based on Food Groups for Estimating Individual Nutrient Intake.

The Japanese Journal of Nutrition and Dietetics ◽

10.5264/eiyogakuzashi.59.221 ◽

2001 ◽

Vol 59 (5) ◽

pp. 221-232 ◽

Cited By ~ 94

Author(s):

Keiko Takahashi ◽

Yukio Yoshimura ◽

Tae Kaimoto ◽

Daisuke Kunii ◽

Tatsushi Komatsu ◽

...

Keyword(s):

Food Frequency Questionnaire ◽

Nutrient Intake ◽

Food Groups ◽

Food Frequency

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The Association between Daily Total Dietary Nutrient Intake and Recent Glycemic Control States of Non-Pregnant Adults 20+ Years Old from NHANES 1999–2018 (Except for 2003–2004)

Nutrients ◽

10.3390/nu13114168 ◽

2021 ◽

Vol 13 (11) ◽

pp. 4168

Author(s):

Yin Bai ◽

Hao Zhang ◽

Jie Yang ◽

Lei Peng

Keyword(s):

Glycemic Control ◽

Vitamin B6 ◽

Nutrient Intake ◽

Roc Analysis ◽

Glycosylated Hemoglobin ◽

Dietary Vitamin ◽

P Value ◽

Dependent Variables ◽

Dietary Nutrient ◽

Daily Total

(1) Background: Although daily total dietary nutrient intakes were potentially important factors in maintaining glycemic balance, their overall effect on glycemic control was still unclear among American adults. Objectives: We aimed to examine the association between daily total dietary nutrient intake and recent glycemic control status (RGCS). Methods: This cohort was composed of 41,302 individuals from the National Health and Nutrition Examination Survey (NHANES). The daily total intake of dietary nutrients and RGCS were independent and dependent variables, respectively. To evaluate their association, we carried out binary logistic regression, model fitting, linear discriminant analysis, and the receiver operator characteristic (ROC) analysis. Results: The result of robust check model showed that only the daily total dietary vitamin B6 intake (adjusted OR = 0.848; 95% CI: 0.738, 0.973; p-value = 0.019) was significantly negatively correlated with RGCS. When daily total dietary vitamin B6 intake and glycosylated hemoglobin (HbA1c) were used as independent variables and dependent variables, respectively, to fit the curves and lines, the established robust check model could distinguish American adults with different RGCS well. Moreover, the robust check model results of ROC analysis indicated that daily total dietary vitamin B6 intake might be a potential predictor for RGCS (AUC = 0.977; 95% CI: 0.974, 0.980; p-value < 0.001). (2) Conclusions: This study showed that only daily total dietary vitamin B6 intake was a beneficial factor in RGCS, but it might need further multicenter or prospective studies to verify whether vitamin B6 had biological implications and public health meaning for glycemic control among American adults (specifically referred to non-pregnant participants over 20 years old).

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