The Association between Daily Total Dietary Nutrient Intake and Recent Glycemic Control States of Non-Pregnant Adults 20+ Years Old from NHANES 1999–2018 (Except for 2003–2004)

(1) Background: Although daily total dietary nutrient intakes were potentially important factors in maintaining glycemic balance, their overall effect on glycemic control was still unclear among American adults. Objectives: We aimed to examine the association between daily total dietary nutrient intake and recent glycemic control status (RGCS). Methods: This cohort was composed of 41,302 individuals from the National Health and Nutrition Examination Survey (NHANES). The daily total intake of dietary nutrients and RGCS were independent and dependent variables, respectively. To evaluate their association, we carried out binary logistic regression, model fitting, linear discriminant analysis, and the receiver operator characteristic (ROC) analysis. Results: The result of robust check model showed that only the daily total dietary vitamin B6 intake (adjusted OR = 0.848; 95% CI: 0.738, 0.973; p-value = 0.019) was significantly negatively correlated with RGCS. When daily total dietary vitamin B6 intake and glycosylated hemoglobin (HbA1c) were used as independent variables and dependent variables, respectively, to fit the curves and lines, the established robust check model could distinguish American adults with different RGCS well. Moreover, the robust check model results of ROC analysis indicated that daily total dietary vitamin B6 intake might be a potential predictor for RGCS (AUC = 0.977; 95% CI: 0.974, 0.980; p-value < 0.001). (2) Conclusions: This study showed that only daily total dietary vitamin B6 intake was a beneficial factor in RGCS, but it might need further multicenter or prospective studies to verify whether vitamin B6 had biological implications and public health meaning for glycemic control among American adults (specifically referred to non-pregnant participants over 20 years old).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v2 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods: Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile. Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR=1.55, 95% CI: 1.03-2.33). Similar results were also observed for vitamin B6 (OR=1.63, 95% CI: 1.08-2.46), vitamin C (OR=1.59, 95% CI: 1.05-2.42), niacin (OR=1.65, 95% CI: 1.08-2.51), and vitamin K (second versus fourth quartile: OR=1.60, 95% CI: 1.05-2.44).Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer.Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Variation of HbA1c with Hemoglobin level: A comparative study betweenD10 Biorad (HpLC) and Nycocard (Immunochromatography) analyser.

10.21203/rs.3.rs-688900/v1 ◽

2021 ◽

Author(s):

Arabinda Mohan Bhattarai ◽

Sulochana Parajuli ◽

Salina Pradhananga

Keyword(s):

Glycemic Control ◽

High Performance ◽

Glycosylated Hemoglobin ◽

Cross Sectional Study ◽

Hplc Method ◽

P Value ◽

Diabetic Patients ◽

Cross Sectional ◽

Self Monitoring ◽

Background Measurement

Abstract Background Measurement of Glycosylated Hemoglobin (HbA1c) is an established procedure in evaluating long-term glycemic control in diabetic patients. It is an index of glycemic control which is not affected by diurnal glucose fluctuations. Methods A retrospective cross sectional study was performed in the Biochemistry department of Shree Birendra Hospital, Kathmandu, Nepal involving 100 known cases of type 2 diabetes mellitus. This study was designed to study the variation of HbA1c with hemoglobin levels. HbA1c was measured by Bio-Rad D10 (HPLC method) and Nycocard (Immunochromatography method). Linear regressive analysis with correlation coefficient was used to compare HbA1c with hemoglobin levels and a p-value < 0.05 is considered statistically significant. Results There was a strong correlation of HbA1c values with Hemoglobin levels in HPLC methods p = 0.001, r = 0.6, however no such correlation was seen in Nycocard method p = 0.6, r = 0.08. Conclusion Cation-exchange high performance liquid chromatography (HPLC) is the latest method introduced in our country Nepal. Therefore, interference caused by Hemoglobin variants needs to be evaluated by methods such as HPLC. In such situations, we may consider fructosamine, glycated serum albumin or self-monitoring of blood glucose as an adjunct to HbA1C measurements.

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study

Nutrition & Metabolism ◽

10.1186/s12986-020-00521-4 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods Data on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutrient intake quartile relative to that in the highest quartile. Results The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI 1.08–2.46), vitamin C (OR = 1.59, 95% CI 1.05–2.42), niacin (OR = 1.65, 95% CI 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI 1.05–2.44). Conclusions Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (https://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v1 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China.Methods Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile.Results The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2 + risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR = 1.55, 95% CI: 1.03–2.33). Similar results were also observed for vitamin B6 (OR = 1.63, 95% CI: 1.08–2.46), vitamin C (OR = 1.59, 95% CI: 1.05–2.42), niacin (OR = 1.65, 95% CI: 1.08–2.51), and vitamin K (second versus fourth quartile: OR = 1.60, 95% CI: 1.05–2.44).Conclusions Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2 + risk. Nutrients may influence the development of higher grade CIN and cervical cancer.Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v3 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

Abstract Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods: Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile. Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR=1.55, 95% CI: 1.03-2.33). Similar results were also observed for vitamin B6 (OR=1.63, 95% CI: 1.08-2.46), vitamin C (OR=1.59, 95% CI: 1.05-2.42), niacin (OR=1.65, 95% CI: 1.08-2.51), and vitamin K (second versus fourth quartile: OR=1.60, 95% CI: 1.05-2.44). Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer. Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

10.21203/rs.3.rs-22315/v4 ◽

2020 ◽

Author(s):

Zhe Wang ◽

Aimin Yang ◽

Jing Yang ◽

Weihong Zhao ◽

Zhilian Wang ◽

...

Keyword(s):

Cervical Intraepithelial Neoplasia ◽

Food Frequency Questionnaire ◽

Vitamin B6 ◽

Nutrient Intake ◽

Laboratory Tests ◽

Intraepithelial Neoplasia ◽

Food Frequency ◽

Dietary Nutrient ◽

Physical Examinations ◽

Fourth Quartile

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Depression and Vegetarians: Association between Dietary Vitamin B6, B12 and Folate Intake and Global and Subcortical Brain Volumes

Nutrients ◽

10.3390/nu13061790 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1790

Author(s):

Samuel Berkins ◽

Helgi Birgir Schiöth ◽

Gull Rukh

Keyword(s):

Vitamin B12 ◽

Brain Structure ◽

Vitamin B6 ◽

Significant Interaction ◽

Longitudinal Design ◽

Folate Intake ◽

Dietary Vitamin ◽

Brain Volumes ◽

Subcortical Brain ◽

Depression Status

Deficiency of vitamin B6 and vitamin B12, mostly in vegetarians, is found to be associated with depression and adverse neurological function. We investigated whether vitamin B6, B12, and folate have an effect on brain structure, especially among depressed people who follow a specific diet. The study sample comprised 9426 participants from the UK Biobank cohort with a mean age of 62.4 years. A generalized linear model controlling for age, sex, body mass index, ethnicity, town send deprivation index, educational qualification, smoking, and alcohol intake was used to test the association between study groups and structural brain volumes. Depression was more prevalent, and intake of vitamin B6 and B12 was lower among vegetarians, while non-vegetarians had a lower intake of folate. Overall, no significant association was observed between vitamin B6, B12, and folate intakes and both global and subcortical brain volumes among participants with depression. However, vitamin B12 intake was positively associated with right pallidum among non-depressed participants, and a significant interaction between vitamin B12 intake and depression status on the right pallidum was observed. Also, a significant interaction between folate intake and depression status on grey matter (GM) volume and left thalamus was observed. Upon diet stratification, folate intake is associated with total brain volume and GM volume among vegetarians with depression. Furthermore, no significant associations were observed for subcortical regions. Our findings suggest that dietary intake of vitamin B6 and B12 might have an effect on brain structure. Vegetarians, particularly those who suffer from depression may benefit from supplementing their diets with vitamins B6, B12, and folate to ensure brain health. Further studies, especially with a larger sample size and longitudinal design, are needed to confirm these findings.

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Intake of Potatoes Is Associated with Higher Diet Quality, and Improved Nutrient Intake and Adequacy among US Adolescents: NHANES 2001–2018 Analysis

Nutrients ◽

10.3390/nu13082614 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2614

Author(s):

Sanjiv Agarwal ◽

Victor L. Fulgoni

Keyword(s):

Vitamin C ◽

Vitamin K ◽

Diet Quality ◽

Vitamin B6 ◽

Nutrient Intake ◽

Healthy Eating Index ◽

Cross Sectional ◽

Recall Data ◽

Fiber Protein ◽

Potato Consumption

Potatoes are nutrient rich white vegetables, however, research on their impact on public health is limited. The objective of this study was to provide updated evaluation of the cross-sectional association between potato consumption and diet quality, nutrient intake and adequacy. Twenty-four hour diet recall data from adolescents (n = 16,633; age 9–18 years) were used to assess intakes. Usual intakes of nutrients were determined using the National Cancer Institute method and diet quality was calculated using the Healthy Eating Index-2015 (HEI-2015) after adjusting for demographic factors. Consumers of potatoes (baked or boiled potatoes, mashed potatoes and potato mixtures, fried potatoes, and potato chips) had higher (p < 0.05) HEI-2015 total score and subcomponent scores for total vegetables, total protein foods, and refined grain than non-consumers. Consumers also had higher (p < 0.05) intake of energy, dietary fiber, protein, copper, magnesium, phosphorus, potassium, selenium, sodium, zinc, niacin, vitamin B6, vitamin C, vitamin K and total choline; and higher (p < 0.05) adequacy for protein, copper, magnesium, phosphorus, potassium, zinc, thiamine, niacin, vitamin B6, vitamin C, and vitamin K than non-consumers. In conclusion, adolescent potato consumption was associated with higher diet quality, nutrient intake, and adequacy and therefore encouraging their consumption may be an effective strategy for improving nutritional status.

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