Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

Abstract BackgroundA relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children.MethodsThis was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.ResultsWe included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05).ConclusionProteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

10.21203/rs.3.rs-26481/v4 ◽

2020 ◽

Author(s):

Francois Folefack Kaze ◽

Seraphin Nguefack ◽

Constantine Menkoh Asong ◽

Jules Clement Nguedia Assob ◽

Jobert Richie Nansseu ◽

...

Keyword(s):

Birth Weight ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Paediatric Hospital ◽

Renal Markers ◽

History Of ◽

Birth Data ◽

Sub Saharan

Abstract Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children.Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

10.21203/rs.3.rs-26481/v2 ◽

2020 ◽

Author(s):

Francois Folefack Kaze ◽

Seraphin Nguefack ◽

Constantine Menkoh Asong ◽

Jules Clement Nguedia Assob ◽

Jobert Richie Nansseu ◽

...

Keyword(s):

Birth Weight ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Paediatric Hospital ◽

Renal Markers ◽

History Of ◽

Birth Data ◽

Sub Saharan

Abstract Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children.Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Birth weight and renal markers in children aged 5–10 years in Cameroon: a cross-sectional study

BMC Nephrology ◽

10.1186/s12882-020-02133-9 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Francois Folefack Kaze ◽

Seraphin Nguefack ◽

Constantine Menkoh Asong ◽

Jules Clement Nguedia Assob ◽

Jobert Richie Nansseu ◽

...

Keyword(s):

Birth Weight ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Paediatric Hospital ◽

Renal Markers ◽

History Of ◽

Birth Data ◽

Sub Saharan

Abstract Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children. Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [< 2500 g], normal BW (NBW) [2500-3999 g] and high BW (HBW) [> 4000 g] children, aged 5–10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation. Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3–8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p = 0.233). Seven (8.7%) children had proteinuria with 19, 2.2 and 14.3% having LBW, NBW and HBW, respectively (p = 0.051). Equivalent figures were 18 (22.5%), 14.3, 24.2 and 28.6% for decreased GFR, respectively (p = 0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p > 0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Birth Weight and Renal Markers in Children Aged 5 – 10 Years in Cameroon: A Cross-Sectional Study

10.21203/rs.3.rs-26481/v1 ◽

2020 ◽

Author(s):

Francois Folefack Kaze ◽

Seraphin Nguefack ◽

Constantine Menkoh Asong ◽

Jules Clement Nguedia Assob ◽

Jobert Richie Nansseu ◽

...

Keyword(s):

Birth Weight ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Paediatric Hospital ◽

Renal Markers ◽

History Of ◽

Birth Data ◽

Sub Saharan

Abstract Background A relationship exists between the birth weight (BW) and the glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children. Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using Schwartz equation. Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) others children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW respectively (p=0.051). Equivalents figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decrease GFR (p=0.818). There was a trends towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Birth weight and renal markers in children aged 5 – 10 years in Cameroon: A cross-sectional study

10.21203/rs.3.rs-26481/v5 ◽

2020 ◽

Author(s):

Francois Folefack Kaze ◽

Seraphin Nguefack ◽

Constantine Menkoh Asong ◽

Jules Clement Nguedia Assob ◽

Jobert Richie Nansseu ◽

...

Keyword(s):

Birth Weight ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Paediatric Hospital ◽

Renal Markers ◽

History Of ◽

Birth Data ◽

Sub Saharan

Abstract Background A relationship exists between birth weight (BW) and glomerular filtration rate (GFR) in postnatal kidney. Willing to fill a gap of knowledge in sub-Saharan Africa, we assessed the effect of BW on blood pressure (BP), proteinuria and GFR among Cameroonians children. Methods This was a cross-sectional hospital-based study from January to April 2018 at the Yaounde Gynaeco-Obstetric and Paediatric Hospital (YGOPH). We recruited low BW (LBW) [<2500g], normal BW (NBW) [2500-3999g] and high BW (HBW) [>4000g] children, aged 5-10 years, born and followed-up at YGOPH. We collected socio-demographic, clinical (weight, height, BP), laboratory (proteinuria, creatinine), maternal and birth data. The estimated GFR was calculated using the Schwartz equation.Results We included 80 children (61.2% boys) with 21 (26.2%) LBW, 45 (56.2%) NBW and 14 (15.5%) HBW; the median (interquartile range) age was 7.3 (6.3-8.1) years and 17 (21.2%) were overweight/obese. Two (2.5%) children, all with a NBW (4.4%), had an elevated BP whereas 2 (2.5%) other children, all with a LBW (9.5%), had hypertension (p=0.233). Seven (8.7%) children had proteinuria with 19%, 2.2% and 14.3% having LBW, NBW and HBW, respectively (p=0.051). Equivalent figures were 18 (22.5%), 14.3%, 24.2% and 28.6% for decreased GFR, respectively (p=0.818). There was a trend towards an inverse relationship between BW and BP, proteinuria and GFR (p>0.05). Conclusion Proteinuria is more pronounced in childhood with a history of LBW and HBW while LBW children are more prone to develop hypertension. Regular follow-up is needed to implement early nephroprotective measures among children with abnormal BW.

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Prevalence and Associated Factors of Hypertension among Assosa town, WesternEthiopia, 2018

Cardiology Open Access ◽

10.33140/coa.05.02.06 ◽

2020 ◽

Vol 5 (2) ◽

Keyword(s):

Health Center ◽

General Hospital ◽

Associated Factors ◽

Sampling Technique ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Chi Square ◽

Cross Sectional ◽

History Of ◽

Sub Saharan

Background: Hypertension, the global first and third risk for mortality and disease burden respectively, is recording an increment in Sub-Saharan Africa countries. This study aimed to identify prevalence and its associated risk factor of Hypertension in the Assosa town. Objective: To identify prevalence and factors associated with hypertension in the study area to increase it’s prevention and control methods. Methods & materials: Institutional based cross sectional study design with quota non-probability sampling technique was conducted among patients visited OPD units ofAssosa General Hospital (AGH) andAssosa Health Center(AHC) fromMarch to June 2018. All outpatients were included. To collect data, pre-tested structured questionnaire and face to face interviews were used. Components ofstatisticalresearch software SPSS version-21 like frequency table, chi-square test of independence & logistic regression was used to enter, analyze, summarize and characterize disease and associated factors data. Result: The study was conducted among 194 participants(152 from AGH and 42 from AHC) with 102 males and 92 females. Prevalence of hypertension among patients visited outpatient units of Assosa General Hospital and Assosa Health Center was 17.5%, and was slightly highest in male than female. Associated factors for hypertension among patients visited OPD units of AGH & AHC were history of hypertension in the family (CI=95% and COR=4.497(1.133-17.844) and being private employee (CI=95% and COR=0.0017(0.001-0.407). Conclusion & recommendation: Prevalence of HTN in the Assosa town, was low and influenced by some risk factors like work status and previousfamily history of hypertension. Even if usual usage ofsalt and using vegetable oil was not associated factor, being private employee were independent factor of HTN. In-depth study is recommended for further investigation. To increase preventative methods of HTN, health education supported by mass media, illustrative posters and anotherstrategies at every government & non government work sector are recommended.

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Prevalence and characteristics of accidental perineal tears during childbirth in a communal medical center in Guinea-Conakry: a cross-sectional study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20196053 ◽

2019 ◽

Vol 9 (1) ◽

pp. 389

Author(s):

Oumou Hawa Bah ◽

Boubacar Alpha Diallo ◽

Aboubacar Fode Momo Soumah ◽

Boubacar Siddi Diallo

Keyword(s):

Medical Center ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Sectional Study ◽

Cross Sectional ◽

Prevalence Studies ◽

Genital Mutilation ◽

Perineal Tears ◽

History Of ◽

Sub Saharan

Background: Prevalence studies are still rare in sub-Saharan Africa on perineal tears. We conducted this cross-sectional study in a communal hospital in Guinea-Conakry, with the objective of this study was to determining the prevalence and characteristics of post-obstetric perineal lesions.Methods: All deliveries between March 1st and August 31st, 2014 were reviewed. We included in the analysis all the single deliveries with perineal tears. The Anglo-Saxon classification of perineal tears was used.Results: The prevalence of perineal tears was 5.7% with 5.4% benign lesions and 0.3% severe lesions. We did not register 4th degree lesions. The average age of parturient was 22 years. The majority (96.6%) of parturient had a history of genital mutilation and perineal scarring (60.3%).Conclusions: This prevalence appear low compared to those reported in other studies in Africa and point to the need for more sophisticated studies to have a better estimate of the prevalence of perineal tears in Guinea-Conakry.

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Diabetes mellitus among patients attending TB clinics in Dar es Salaam: a descriptive cross-sectional study

BMC Infectious Diseases ◽

10.1186/s12879-019-4539-5 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Patricia J. Munseri ◽

Henrika Kimambo ◽

Kisali Pallangyo

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

Cross Sectional Study ◽

Dar Es Salaam ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Family History Of Diabetes ◽

History Of ◽

Sub Saharan

Abstract Background A bi-directional interaction between diabetes mellitus and tuberculosis is well established and has been likened to that between HIV and TB. Whereas HIV screening is standard of care test in sub Saharan Africa TB programs, the same is not true for diabetes mellitus (DM). Sub Saharan Africa, a region with high TB infection rates, is going through an epidemiological transition with rapidly rising prevalence of diabetes. We aimed at characterizing TB patients with DM in order to identify factors associated with TB-DM dual disease among patients attending TB clinics in Dar es Salaam. Methods A cross-sectional study was conducted between September 2016 and January 2017 among patients attending TB clinics in Dar es Salaam. We collected socio-demographic characteristics, anthropometric measurements and screened for diabetes by measuring fasting blood glucose that was followed by a 2 h postprandial glucose for participants with impaired fasting blood glucose. We examined for socio-demographic and clinical factors associated with diabetes using logistic regression analysis. Results Of the 660 enrolled participants with TB, 25 (3.8%) were on treatment for diabetes while 39 (6.1%) and 147 (23%) of the remaining 635 participants were ultimately diagnosed with DM and impaired fasting blood glucose respectively. The overall prevalence of DM was 9.7% (64/660). Independent risk factors for diabetes included: age > 44 years {OR 4.52, 95% CI: [1.28–15.89]}; family history of diabetes {OR 3.42, 95% [CI 1.88–6.21]}. HIV sero-positive TB patients were less likely to have DM compared to those who were HIV sero-negative {OR 0.35, 95% CI [0.17–0.73]}. Conclusions Screening for diabetes should be advocated for TB patients aged above 44 years and/or with a family history of diabetes. HIV sero-negative TB patients were more likely to have DM compared to those who were HIV sero-positive. Further studies are needed to confirm this observation and the underlying factors.

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Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia

Wellcome Open Research ◽

10.12688/wellcomeopenres.15482.2 ◽

2020 ◽

Vol 5 ◽

pp. 61

Author(s):

Comfort Rutty Phiri ◽

Amy S. Sturt ◽

Emily L. Webb ◽

Namakau Chola ◽

Richard Hayes ◽

...

Keyword(s):

Cross Sectional Study ◽

Vaginal Swab ◽

Sub Saharan Africa ◽

Cross Sectional ◽

Urinary Schistosomiasis ◽

Home Based ◽

Sub Saharan ◽

Cervicovaginal Lavage ◽

Female Genital

Background: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that is difficult to diagnose and is part of the wider spectrum of urogenital disease caused by the waterborne parasite Schistosoma haematobium. Over 90% of human schistosomiasis cases are found in sub-Saharan Africa with 3.8 million people infected with schistosomes in Zambia. Reported FGS prevalence ranges from 33-75% of those with urinary schistosomiasis in endemic areas, suggesting a potentially high FGS burden in Zambia alone. The Bilharzia and HIV (BILHIV) study evaluated home self-sampling genital collection methods for the diagnosis of FGS. Methods: Eligible participants included non-pregnant, sexually active women aged 18-31 who were previously recruited for the HPTN 071 (PopART) trial in Livingstone, Zambia. Household demographic and symptom questionnaires were administered by community workers. Participants were offered vaginal and cervical self-swabs and a urine cup. Cervicovaginal lavage (CVL) was performed in clinic by midwives. Information was collected from participants on the acceptability and feasibility of genital self-sampling. Results: From January-August 2018, 603 women were enrolled, and 87.3% (527/603) completed clinic follow up. A high proportion of participants indicated that self-collection of specimens was “easy” or “very easy” on a 5-point Likert scale. A high proportion of women would be willing to self-collect all three specimens again in future: vaginal swab 96.7% (583/603), cervical swab 96.5% (582/603), and urine 96.2% (580/603). Overall, 90.0% (543/603) preferred to self-collect samples at home, compared with sampling in the clinic Home-based self-sampling was preferred over provider-based sampling in the clinic due to greater privacy 65.0% (353/543), convenience 51.4% (279/543) and lack of needed transportation 17.7% (96/543). Conclusions: Home based genital self-sampling for FGS diagnosis is highly acceptable. This scalable method may inform future efforts for community-based diagnosis of FGS

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