Determinants of Macular Ganglion Cell–Inner Plexiform Layer Thickness in Normal Chinese Adults

Abstract Background To determine the influences of multiple demographic and ocular factors on the measurements of macular ganglion cell–inner plexiform layer (GCIPL) thickness in normal Chinese adults. Methods This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated. Results The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was (84.56 ± 5.36), (81.32 ± 5.58), (83.08 ± 5.37), (85.70 ± 5.95), (87.15 ± 6.26), (85.07 ± 6.11), (82.46 ± 5.76), and (83.88 ± 5.59) µm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001–0.117; effects enhanced if age over 40 years), thinner pRNFL (all P < 0.001), and weaker signal strength (all P < 0.001). No significant difference was found between males and females (P = 0.069–0.842), and between right eyes and the left eyes (P = 0.160–0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135–0.968). Conclusions Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength. This is relevant in comprehensively understanding the normative data and differentiating normal aging from abnormalities.

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Determinants of Macular Ganglion Cell–Inner Plexiform Layer Thickness in Normal Chinese Adults

10.21203/rs.3.rs-29159/v2 ◽

2020 ◽

Author(s):

Xiaoyu Xu ◽

Hui Xiao ◽

Kunbei Lai ◽

Xinxing Guo ◽

Jingyi Luo ◽

...

Keyword(s):

Ganglion Cell ◽

Plexiform Layer ◽

Signal Strength ◽

Retinal Nerve Fibre Layer ◽

Older Age ◽

Inner Plexiform Layer ◽

High Definition ◽

Chinese Adults ◽

Significant Difference ◽

Over 40 Years

Abstract Background: Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants of macular GCIPL thickness in normal Chinese adults.Methods: This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated.Results: The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was 84.56 ± 5.36, 81.32 ± 5.58, 83.08 ± 5.37, 85.70 ± 5.95, 87.15 ± 6.26, 85.07 ± 6.11, 82.46 ± 5.76, and 83.88 ± 5.59 μm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001 - 0.117; effects enhanced if age over 40 years), thinner pRNFL (all P <0.001), and weaker signal strength (all P <0.001). No significant difference was found between males and females (P = 0.069 - 0.842), and between right eyes and the left eyes (P = 0.160 - 0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135 - 0.968). Conclusions: Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength.

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Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults

BMC Ophthalmology ◽

10.1186/s12886-021-02023-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiaoyu Xu ◽

Hui Xiao ◽

Kunbei Lai ◽

Xinxing Guo ◽

Jingyi Luo ◽

...

Keyword(s):

Ganglion Cell ◽

Plexiform Layer ◽

Signal Strength ◽

Retinal Nerve Fibre Layer ◽

Older Age ◽

Inner Plexiform Layer ◽

High Definition ◽

Chinese Adults ◽

Significant Difference ◽

Over 40 Years

Abstract Background Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants of macular GCIPL thickness in normal Chinese adults. Methods This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated. Results The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was 84.56 ± 5.36, 81.32 ± 5.58, 83.08 ± 5.37, 85.70 ± 5.95, 87.15 ± 6.26, 85.07 ± 6.11, 82.46 ± 5.76, and 83.88 ± 5.59 μm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001–0.117; effects enhanced if age over 40 years), thinner pRNFL (all P < 0.001), and weaker signal strength (all P < 0.001). No significant difference was found between males and females (P = 0.069–0.842), and between right eyes and the left eyes (P = 0.160–0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135–0.968). Conclusions Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength. This is relevant in comprehensively understanding the normative data and differentiating normal aging from abnormalities.

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Thinning rates of retinal nerve layer and ganglion cell-inner plexiform layer in various stages of normal tension glaucoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314899 ◽

2019 ◽

Vol 104 (8) ◽

pp. 1131-1136

Author(s):

Hiroko Inuzuka ◽

Akira Sawada ◽

Masayuki Inuzuka ◽

Tetsuya Yamamoto

Keyword(s):

Ganglion Cell ◽

Nerve Fibre ◽

Plexiform Layer ◽

Normal Tension Glaucoma ◽

Retinal Nerve Fibre Layer ◽

Inner Plexiform Layer ◽

Advanced Stage ◽

Rates Of Change ◽

Significant Difference ◽

Nerve Fibre Layer

AimsTo compare the changes in the macular retinal nerve fibre layer (mRNFL), macular ganglion cell layer and inner plexiform layer (mGCIPL), and circumpapillary retinal nerve fibre layer (cpRNFL) in various stages of normal tension glaucoma (NTG) using spectral domain optical coherence tomography.MethodsEyes with NTG (n=218) were assigned into three groups based on initial mean deviation (MD) as follows: mild (MD>−6 dB), moderate (−6 dB≥MD≥−12 dB) and severe (−12 dB>MD>−20 dB). Annual rates of change in mRNFL, mGCIPL and cpRNFL thickness were calculated by linear regression analysis.ResultsAge, gender, spherical equivalent, and average intraocular pressure during follow-up were not significantly different among the three groups. There were significant differences in the mRNFL, mGCIPL and cpRNFL among the three groups at baseline (p<0.0001 in all sectors except for the mRNFL in the superonasal sector). The average thinning rates of the mRNFL, mGCIPL and cpRNFL were −0.38±0.32 µm/year, −0.62±0.46 µm/year and −0.86±0.83 µm/year, respectively. No significant difference in the rates of change in the mRNFL and mGCIPL were found among the groups in any sector. However, there was a significant difference in the rate of change in the cpRNFL among the groups (in all sectors: p<0.0001).ConclusionsChanges in the mRNFL and mGCIPL can reflect the progression of NTG even in its advanced stage. However, careful interpretation of changes in the cpRNFL in the advanced stage of glaucoma is warranted due to a potential floor effect.

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Diagnostic value of ganglion cell-inner plexiform layer for early detection of ethambutol-induced optic neuropathy

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312063 ◽

2018 ◽

Vol 103 (3) ◽

pp. 379-384 ◽

Cited By ~ 3

Author(s):

Ju-Yeun Lee ◽

Jinu Han ◽

Jeong Gi Seo ◽

Kyung-Ah Park ◽

Sei Yeul Oh

Keyword(s):

Early Detection ◽

Ganglion Cell ◽

Optic Neuropathy ◽

Plexiform Layer ◽

Diagnostic Value ◽

Retinal Nerve Fibre Layer ◽

Field Pattern ◽

Control Group ◽

Inner Plexiform Layer ◽

Minimum Thickness

AimTo evaluate the diagnostic value of macular ganglion cell-inner plexiform layer (mGCIPL) thickness versus peripapillary retinal nerve fibre layer (pRNFL) thickness for the early detection of ethambutol-induced optic neuropathy (EON).MethodsTwenty-eight eyes of 15 patients in the EON group and 100 eyes of 53 healthy subjects in the control group were included. All patients with EON demonstrated the onset of visual symptoms within 3 weeks. Diagnostic power for pRNFL and mGCIPL thicknesses measured by Cirrus spectral-domain optical coherence tomography was assessed by area under the receiver operating characteristic (AUROC) curves and sensitivity.ResultsAll of the mGCIPL thickness measurements were thinner in the EON group than in the control group in early EON (p<0.001). All of pRNFL thicknesses except inferior RNFL showed AUROC curves above 0.5, and all of the mGCIPL thicknesses showed AUROC curves above 0.5. The AUROC of the average mGCIPL (0.812) thickness was significantly greater than that of the average pRNFL (0.507) thickness (p<0.001). Of all the mGCIPL-related parameters considered, the minimum thickness showed the greatest AUROC value (0.863). The average mGCIPL thickness showed a weak correlation with visual field pattern standard deviations (r2=0.158, p<0.001).ConclusionsIn challenging cases of EON, the mGCIPL thickness has better diagnostic performance in detecting early-onset EON as compared with using pRNFL thickness. Among the early detection ability of mGCIPL thickness, minimum GCIPL thickness has high diagnostic ability.

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The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

BioMed Research International ◽

10.1155/2017/8923819 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Maja Zivkovic ◽

Vesna Jaksic ◽

Athanassios Giarmoukakis ◽

Michael Grentzelos ◽

Marko Zlatanovic ◽

...

Keyword(s):

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Plexiform Layer ◽

Inner Plexiform Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Significant Difference ◽

Retinal Nerve Fiber

Purpose. To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods. 89 patients (124 eyes) with established myopia range from −3.0 to −8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results. Mean RNFL thickness prior to LASIK was 93.86±12.17 μm while the first month and the sixth month postoperatively were 94.01±12.04 μm and 94.46±12.27 μm, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p>0.05). Mean GC-IPL thickness was 81.70±7.47 μm preoperatively with no significant difference during the follow-up period (82.03±7.69 μm versus 81.84±7.64 μm; p>0.05). Conclusion. RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.

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