Diagnostic value of ganglion cell-inner plexiform layer for early detection of ethambutol-induced optic neuropathy

2018 ◽  
Vol 103 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Ju-Yeun Lee ◽  
Jinu Han ◽  
Jeong Gi Seo ◽  
Kyung-Ah Park ◽  
Sei Yeul Oh
Keyword(s):  
Early Detection ◽  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Plexiform Layer ◽  
Diagnostic Value ◽  
Retinal Nerve Fibre Layer ◽  
Field Pattern ◽  
Control Group ◽  
Inner Plexiform Layer ◽  
Minimum Thickness

AimTo evaluate the diagnostic value of macular ganglion cell-inner plexiform layer (mGCIPL) thickness versus peripapillary retinal nerve fibre layer (pRNFL) thickness for the early detection of ethambutol-induced optic neuropathy (EON).MethodsTwenty-eight eyes of 15 patients in the EON group and 100 eyes of 53 healthy subjects in the control group were included. All patients with EON demonstrated the onset of visual symptoms within 3 weeks. Diagnostic power for pRNFL and mGCIPL thicknesses measured by Cirrus spectral-domain optical coherence tomography was assessed by area under the receiver operating characteristic (AUROC) curves and sensitivity.ResultsAll of the mGCIPL thickness measurements were thinner in the EON group than in the control group in early EON (p<0.001). All of pRNFL thicknesses except inferior RNFL showed AUROC curves above 0.5, and all of the mGCIPL thicknesses showed AUROC curves above 0.5. The AUROC of the average mGCIPL (0.812) thickness was significantly greater than that of the average pRNFL (0.507) thickness (p<0.001). Of all the mGCIPL-related parameters considered, the minimum thickness showed the greatest AUROC value (0.863). The average mGCIPL thickness showed a weak correlation with visual field pattern standard deviations (r2=0.158, p<0.001).ConclusionsIn challenging cases of EON, the mGCIPL thickness has better diagnostic performance in detecting early-onset EON as compared with using pRNFL thickness. Among the early detection ability of mGCIPL thickness, minimum GCIPL thickness has high diagnostic ability.

Temporal Raphe Sign for Discrimination of Glaucoma from Optic Neuropathy in Eyes with Macular Ganglion Cell–Inner Plexiform Layer Thinning

Ophthalmology ◽  
2019 ◽  
Vol 126 (8) ◽  
pp. 1131-1139 ◽  
Author(s):  
Jinho Lee ◽  
Young Kook Kim ◽  
Ahnul Ha ◽  
Yong Woo Kim ◽  
Sung Uk Baek ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Plexiform Layer ◽  
Inner Plexiform Layer

Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes

2013 ◽  
Vol 97 (12) ◽  
pp. 1592-1597 ◽  
Author(s):  
Yih-Chung Tham ◽  
Carol Y Cheung ◽  
Victor T Koh ◽  
Ching-Yu Cheng ◽  
Elizabeth Sidhartha ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Optic Disc ◽  
Nerve Fibre ◽  
Plexiform Layer ◽  
Retinal Nerve Fibre Layer ◽  
Inner Plexiform Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Determinants of Macular Ganglion Cell–Inner Plexiform Layer Thickness in Normal Chinese Adults

2020 ◽  
Author(s):  
Xiaoyu Xu ◽  
Hui Xiao ◽  
Kunbei Lai ◽  
Xinxing Guo ◽  
Jingyi Luo ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Plexiform Layer ◽  
Signal Strength ◽  
Retinal Nerve Fibre Layer ◽  
Older Age ◽  
Inner Plexiform Layer ◽  
High Definition ◽  
Chinese Adults ◽  
Significant Difference ◽  
Over 40 Years

Abstract Background To determine the influences of multiple demographic and ocular factors on the measurements of macular ganglion cell–inner plexiform layer (GCIPL) thickness in normal Chinese adults. Methods This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated. Results The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was (84.56 ± 5.36), (81.32 ± 5.58), (83.08 ± 5.37), (85.70 ± 5.95), (87.15 ± 6.26), (85.07 ± 6.11), (82.46 ± 5.76), and (83.88 ± 5.59) µm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001–0.117; effects enhanced if age over 40 years), thinner pRNFL (all P < 0.001), and weaker signal strength (all P < 0.001). No significant difference was found between males and females (P = 0.069–0.842), and between right eyes and the left eyes (P = 0.160–0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135–0.968). Conclusions Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength. This is relevant in comprehensively understanding the normative data and differentiating normal aging from abnormalities.

Diagnostic Performance of Macular Ganglion Cell/Inner Plexiform Layer Thickness to Discriminate Normal Eye from Eye with Early Glaucoma Using Cirrus Spectral-Domain Optical Coherence Tomography

2019 ◽  
Vol 43 (1) ◽  
pp. 7
Author(s):  
Widya Artini ◽  
Baltazar Bimo Bisara
Keyword(s):  
Ganglion Cell ◽  
Optic Neuropathy ◽  
Diagnostic Performance ◽  
Ganglion Cells ◽  
Plexiform Layer ◽  
Spectral Domain ◽  
Reference List ◽  
Search Term ◽  
Inner Plexiform Layer ◽  
Early Glaucoma

Background: Glaucoma is a progressive optic neuropathy characterized by a progressive loss of retinal ganglion cells (RGC). In glaucomatous optic neuropathy, structural optic nerve changes may occur before detectable functional loss, which can be diagnosed early by detecting loss of RGC. This review was conducted to see the diagnostic performance of macular ganglion cell/inner plexiform layer (GC-IPL) thickness parameters to discriminate normal eye from early glaucoma eye using Cirrus Spectral-domain OCT compared to peri-papilarry Retinal Nerve Fiber Layer (RNFL) thickness parameters. Methods: Literature search was conducted from MEDLINE database using Pubmed, Clinical Key, and ScienceDirect. No publication date was set, and only articles published in English were included. Reference list from the included studies were also checked for potentially relevant articles. Results: Twenty articles were found related to search term. Seven articles met the inclusion criteria. Fourteen others were excluded. All studies revealed significant thinner GC-IPL and RNFL average thickness in glaucoma patients compared to normal patients. GC-IPL Average was inferior to GC-IPL Minimum and RNFL inferior in determining normal eye from early glaucomatous eyes. Studies evaluating the diagnostic performance of Ganglion Cells Complex (GCC) thickness also found low sensitivity values, ranging between 61.0% and 78.6% for average GCC. Conclusion: Diagnostic performance of GC-IPL is comparable to RNFL parameters measurement in detecting early glaucoma eyes. Best performance in detecting early glaucoma were showed by GC-IPL minimum and RNFL inferior.

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