scholarly journals Implication of Retrobulbar and Internal Carotid Artery Blood-Flow-Volume Alterations for the Pathogenesis of Non-arteritic Anterior Ischemic Optic Neuropathy

2021 ◽  
Author(s):  
Zhiyong Fu ◽  
Hongyang Li ◽  
Yanling Wang
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Optic Disc ◽  
Internal Carotid ◽  
Vessel Density ◽  
Ischemic Optic Neuropathy ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Healthy Side

Abstract Background: To analyze blood flow volume alteration that involved both retrobulbar artery and internal carotid artery (ICA) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) and to assess their relevance for the pathogenesis of NAION. Methods: Forty two patients with NAION (unilateral affected) and 42 age-matched controls participated in this study. By head-and-neck computed tomographic angiography (CTA), the diameter of ICA and ophthalmic artery (OA) were measured. By colour Doppler imaging (CDI), the mean blood flow velocity (Vm) and the blood flow volume of ICA and OA were measured or calculated. By optical coherence tomography angiography (OCTA), peripapillary and optic disc vessel density were measured. Data obtained from the affected side of the patients were compared to those of the contralateral healthy side and the control. Results: Compared with the controls and the contralateral healthy side of the patients with NAION, the diameter of ICA, the blood flow volume of ICA and OA, the peripapillary and optic disc vessel density in the affected side decreased significantly (p<0.05). However, there was no statistical difference in the diameter of OA (p=0.179, 0.054 respectively), the Vm of OA (p=0.052, 0.083 respectively), or the Vm of ICA (p=0.364, 0.938 respectively) between groups. Peripapillary and optic disc vessel density were significantly positive correlated with the blood flow volume in ipsilateral ICA and OA in patients with NAION (all p<0.01). Conclusions: The reduction of blood flow volume was more prominent in OA and ICA than decrease of Vm, peripapillary and optic disc vessel density were significantly positive correlated with the blood flow volume of ipsilateral ICA and OA in patients with NAION. This finding may imply a predominant affection of retrobulbar artery and ICA blood flow volume alterations in the pathogenesis of NAION.

scholarly journals Implication of Retrobulbar and internal carotid artery blood-flow-volume alterations for the pathogenesis of non-arteritic anterior ischemic optic neuropathy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhiyong Fu ◽  
Hongyang Li ◽  
Yanling Wang
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Optic Disc ◽  
Internal Carotid ◽  
Vessel Density ◽  
Ischemic Optic Neuropathy ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Healthy Side

Abstract Background To analyze blood flow volume alteration that involved both retrobulbar artery and internal carotid artery (ICA) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) and to assess their relevance for the pathogenesis of NAION. Methods Forty two patients with NAION (unilateral affected) and 42 age-matched controls participated in this study. By head-and-neck computed tomographic angiography (CTA), the diameter of ICA and ophthalmic artery (OA) were measured. By colour Doppler imaging (CDI), the mean blood flow velocity (Vm) and the blood flow volume of ICA and OA were measured or calculated. By optical coherence tomography angiography (OCTA), peripapillary and optic disc vessel density were measured. Data obtained from the affected side of the patients were compared to those of the contralateral healthy side and the control. Results Compared with the controls and the contralateral healthy side of the patients with NAION, the diameter of ICA, the blood flow volume of ICA and OA, the peripapillary and optic disc vessel density in the affected side decreased significantly (p < 0.05). However, there was no statistical difference in the diameter of OA (p = 0.179, 0.054 respectively), the Vm of OA (p = 0.052, 0.083 respectively), or the Vm of ICA (p = 0.364, 0.938 respectively) between groups. Peripapillary and optic disc vessel density were significantly positive correlated with the blood flow volume in ipsilateral ICA and OA in patients with NAION (all p < 0.01). Conclusions The reduction of blood flow volume was more prominent in OA and ICA than decrease of Vm, peripapillary and optic disc vessel density were significantly positive correlated with the blood flow volume of ipsilateral ICA and OA in patients with NAION.

scholarly journals Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery

Stroke ◽  
2003 ◽  
Vol 34 (8) ◽  
pp. 1876-1880 ◽  
Author(s):  
J.F. Soustiel ◽  
T.C. Glenn ◽  
P. Vespa ◽  
B. Rinsky ◽  
C. Hanuscin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Volume Measurement ◽  
Flow Volume ◽  
Blood Flow Volume

scholarly journals Diameter and haemodynamics of internal carotid artery siphon and ophthalmic artery in patients with non-arteritic anterior ischaemic optic neuropathy

2019 ◽  
Author(s):  
Zhiyong Fu ◽  
Hongyang Li ◽  
Yanling Wang
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Blood Flow Velocity ◽  
Ophthalmic Artery ◽  
Internal Carotid ◽  
Flow Volume ◽  
Blood Flow Volume ◽  
Ischaemic Optic Neuropathy ◽  
Anterior Ischaemic Optic Neuropathy

Abstract Purpose To compare the diameter and the haemodynamics of internal carotid artery siphon(ICAS) and ophthalmic artery (OA) in patients with unilateral non-arteritic anterior ischaemic optic neuropathy (NAION) with their contralateral sides and age-matched controls. Methods 30 patients clinically diagnosed with NAION (unilateral affected) and 30 age-matched controls participated in this study. By CTA, the diameter of ICAS and OA in both eyes were measured. By CDI, the blood flow velocity (Vm) and the blood flow volume of ICAS and OA in both eyes were measured or calculated. Measurements on the affected side of the patients were compared to the contralateral healthy side and the controls. Results Compared between the affected sides and the controls, the Vm, the diameter, and the blood flow volume in the ICAS were all significantly decreased (p<0.05), the Vm and the blood flow volume in the OA tended to be reduced (p=0.062, 0.055 respectively), while the difference of the diameter in the OA was insignificant (p=0.116). Compared between the affected sides and the unaffected healthy sides, the Vm, the diameter, and the blood flow volume in the ICAS were also significantly decreased (p<0.05), while no marked differences were detected in the OA, neither for the Vm, the diameter, or the blood flow volume(p=0.178, 0.151,0.173 respectively). Conclusion NAION may be associated with decreased blood flow velocity and diameter in the ICAS . These findings might be potentially useful in the monitoring of NAION.

Impact of transient hypotension on regional cerebral blood flow in humans

2015 ◽  
Vol 129 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Nia C.S. Lewis ◽  
Kurt J. Smith ◽  
Anthony R. Bain ◽  
Kevin W. Wildfong ◽  
Tianne Numan ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Vertebral Artery ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Regional Cerebral Blood

Diameter reductions in the internal carotid artery (ICA) and vertebral artery (VA) contribute to the decline in brain blood with hypotension. The decline in vertebral blood flow with hypotension was greater when carbon dioxide was low; this was not apparent in the ICA.

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