scholarly journals Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

2020 ◽  
Author(s):  
Elina Holopainen ◽  
Svetlana Vakkilainen ◽  
Outi Mäkitie
Keyword(s):  
Cesarean Section ◽  
Short Stature ◽  
Population Based ◽  
Full Term ◽  
Birth Length ◽  
Cesarean Section Delivery ◽  
Cartilage Hair Hypoplasia ◽  
Obstetric History ◽  
Induced Abortions ◽  
Ectopic Pregnancies

Abstract Background: Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All theses features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods: Among 47 Finnish women with CHH, we identified 14 women with ICD codes related to pregnancies, childbirth and puerperium in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results: There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105-139 cm; 4'1'', range 3'5''-4'7''). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5 and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5-50 cm; 1'7'', range 1'6''-1'8'') and weight (3010 g, range 2100-3320 g; 6.6 lb, range 4.6-7.3 lb) of the offspring in full-term singelton pregnancies was normal. Conclusions: Despite CHH mothers' significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and planned cesarean section should be planned in term pregnancies.

scholarly journals Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Elina Holopainen ◽  
Svetlana Vakkilainen ◽  
Outi Mäkitie
Keyword(s):  
Cesarean Section ◽  
Short Stature ◽  
Population Based ◽  
Full Term ◽  
Birth Length ◽  
Cesarean Section Delivery ◽  
Cartilage Hair Hypoplasia ◽  
Obstetric History ◽  
Induced Abortions ◽  
Ectopic Pregnancies

Abstract Background Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All these features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods Among 47 Finnish women with CHH, we identified 14 women with ICD codes related to pregnancies, childbirth and puerperium in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105–139 cm; 4′1′′, range 3′5′′–4′7′’). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5, and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5–50 cm; 1′7′′, range 1′6′′–1′8′′) and weight (3010 g, range 2100–3320 g; 6.6 lb, range 4.6–7.3 lb) of the offspring in full-term singleton pregnancies was normal. Conclusions Despite CHH mothers’ significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and planned cesarean section should be contemplated in term pregnancies.

scholarly journals Outcomes of 42 pregnancies in 14 women with cartilage-hair hypoplasia: a retrospective cohort study

2020 ◽  
Author(s):  
Elina Holopainen ◽  
Svetlana Vakkilainen ◽  
Outi Mäkitie
Keyword(s):  
Cesarean Section ◽  
Short Stature ◽  
Population Based ◽  
Full Term ◽  
Birth Length ◽  
Elective Cesarean Section ◽  
Cesarean Section Delivery ◽  
Cartilage Hair Hypoplasia ◽  
Obstetric History ◽  
Elective Cesarean

Abstract Background Cartilage-hair hypoplasia (CHH) is a rare skeletal dysplasia characterized by disproportionate short stature, immunodeficiency, anemia and risk of malignancies. All these features can affect pregnancy and predispose to maternal and fetal complications. This study aimed to evaluate obstetric history and maternal and fetal outcomes in women with CHH. Methods Among 47 Finnish women with CHH, we identified 14 with pregnancy-related diagnoses in the National Hospital Discharge Registry and obtained detailed data on gynecologic and obstetric history with a questionnaire. Offspring birth length and weight were collected and compared with population-based normal values. Results There were altogether 42 pregnancies in 14 women (median height 124 cm, range 105–139). Twenty-six pregnancies (62%), including one twin pregnancy, led to a delivery. Miscarriages, induced abortions and ectopic pregnancies complicated 9, 5, and 2 pregnancies, respectively. Severe pregnancy-related complications were rare. All women with CHH delivered by cesarean section, mostly due to evident cephalo-pelvic disproportion, and in 25/26 cases at full-term. In the majority, the birth length (median 48 cm, range 45.5–50) and weight (3010 g, range 2100–3320) of the offspring in full-term singleton pregnancies was normal. Conclusions Despite CHH mothers’ significant short stature and other potential CHH-related effects on pregnancy outcome, most pregnancies lead to a term cesarean section delivery. Since fetal growth was generally unaffected, cephalo-pelvic disproportion was evident and elective cesarean section should be planned in term pregnancies.

Growth status of children and adolescents born small for gestational age at full term in Korea: data from the KNHANES-V

2020 ◽  
Vol 33 (6) ◽  
pp. 743-750
Author(s):  
Ji Hyun Kim ◽  
Dong Ho Kim ◽  
Jung Sub Lim
Keyword(s):  
Short Stature ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Nationwide Survey ◽  
Population Based ◽  
Full Term ◽  
Stunted Growth ◽  
Growth Status ◽  
Health And Nutrition ◽  
Parental Height

AbstractObjectivesSmall for gestational age (SGA) status is known to show stunted growth and results in short stature in adults. The aim of this study was to describe the current short stature in subjects born SGA in Korea and to assess catch-up growth (CUG) or non-CUG.MethodsWe analyzed data from 3,524 subjects (1,831 male) aged 1–18 years who were born as full-term singletons and who participated in the Fifth Korean National Health and Nutrition Examination Survey (2010–2011).ResultsThe prevalence of SGA was 13.4% (n=471). Subjects born SGA had fathers with shorter height, shorter mother’s height, and mid-parental height than non-SGA subjects (p<0.05 for all). The odds ratios (ORs) for SGA birth of a short statured father and a short statured mother were 2.00 (95% CI; 1.15–3.47) and 2.11 (95% CI; 1.30–3.40), respectively. Among 471 SGA subjects, 28 subjects (5.9%) were non-CUG, which made up 36.4% of all subjects with short stature. The CUG subjects had a higher father's height, mother’s height, mid-parental height, and current BMI (p<0.05 for all). The non-CUG subjects had a higher percentage of fathers being near-short stature (height<10th percentile; 33.3 vs. 12.7%; p=0.008) and mothers being near-short stature (39.3 vs. 13.9%; p<0.001).ConclusionKorean subjects born SGA had a higher risk of current short stature. This population-based nationwide survey also showed that both father’s and mother’s short stature are risk factors of not only SGA birth but also non-CUG in their children.

Cesarean Section Delivery Is Not a Risk Factor for Development of Inflammatory Bowel Disease: A Population-based Analysis

2016 ◽  
Vol 14 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Charles N. Bernstein ◽  
Ankona Banerjee ◽  
Laura E. Targownik ◽  
Harminder Singh ◽  
Jean Eric Ghia ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Cesarean Section ◽  
Bowel Disease ◽  
Population Based ◽  
Cesarean Section Delivery ◽  
Inflammatory Bowel

scholarly journals Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Rong Yang ◽  
Hui Mei ◽  
Tongzhang Zheng ◽  
Qiang Fu ◽  
Yiming Zhang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Preterm Birth ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Population Based ◽  
Adverse Birth Outcomes ◽  
Cesarean Section Delivery ◽  
Increased Risk

Abstract Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes. Method We conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China. All pregnant women with singleton live birth recorded by the system between January 13 and March 18, 2020, were included. The adverse birth outcomes were preterm birth, low birth weight, neonatal asphyxia, premature rupture of membrane (PROM), and cesarean section delivery. Multivariate logistic regression was used to evaluate the associations between maternal COVID-19 diagnosis and adverse birth outcomes. Results Out of 11,078 pregnant women, 65 were confirmed with coronavirus disease 2019 (COVID-19). No deaths occurred from these confirmed cases or their newborns. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis had an increased risk of preterm birth (OR 3.34, 95% CI 1.60–7.00) and cesarean section (OR 3.63, 95% CI 1.95–6.76). There was no statistical difference in low birth weight, neonatal asphyxia, and PROM between the mothers with and without COVID-19. Among these newborns that were born to mothers with confirmed COVID-19, none was tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive or had abnormal CT results. Only one had diarrhea and three had a fever. Conclusions This population-based cohort study suggests that COVID-19 during the later pregnancy is associated with an increased risk of adverse birth outcomes, including iatrogenic preterm birth and cesarean section delivery. Our data provide little evidence for maternal-fetal vertical transmission of SARS-CoV-2. It is important to monitor the long-term health effects of SARS-CoV-2 infection on pregnant women and their children.

scholarly journals Vaginal Delivery

2021 ◽  
Author(s):  
Kizito Omona
Keyword(s):  
Cesarean Section ◽  
Vaginal Delivery ◽  
Gestational Age ◽  
Full Term ◽  
Normal Vaginal Delivery ◽  
Spontaneous Vaginal Delivery ◽  
Assisted Vaginal Delivery ◽  
Cesarean Section Delivery ◽  
Birth Canal ◽  
Three Stages

Vaginal delivery refers to the birth of offspring in mammals or babies in humans, through the vagina, also known as the “birth canal”. It is the natural method of birth for most mammals excluding those which lay eggs. For women who deliver vaginally, childbirth progresses in three stages: labor, delivery of the baby and delivery of the placenta. There are two types of vaginal delivery: Unassisted vaginal delivery and assisted vaginal delivery. In the later, this assistance can vary from use of medicines to emergency delivery procedures. The following types of vaginal delivery have been noted; (a) Spontaneous vaginal delivery (SVD) (b) Assisted vaginal delivery (AVD), also called instrumental vaginal delivery (c) Induced vaginal delivery and (d) Normal vaginal delivery (NVD), usually used in statistics or studies to contrast with a delivery by cesarean section. Delivery of a full-term newborn occurs at a gestational age of 37–42 weeks, usually determined by the last menstrual period or ultrasonographic dating and evaluation. Nearly 80% of newborns are delivered at full term while approximately 10% of singleton pregnancies are delivered preterm and 10% of all deliveries are post-term.

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