scholarly journals The effect of Rosa canina L. and a polyherbal formulation syrups in patients with attention deficit/hyperactivity disorder: A study protocol for a multicenter randomized controlled trial

2021 ◽  
Author(s):  
Haide Golsorkhi ◽  
Mostafa Qorbani ◽  
Mohammad Kamalinejad ◽  
Saeideh Sabbaghzadegan ◽  
Mohsen Bahrami ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Clinical Manifestations ◽  
Behavioral Disorder ◽  
Childhood And Adolescence ◽  
Rosa Canina ◽  
Hyperactivity Disorder ◽  
Polyherbal Formulation ◽  
Multicenter Randomized Controlled Trial

Abstract Background: Attention deficit/hyperactivity disorder (ADHD) is the most common behavioral disorder in childhood and adolescence. A number of these patients do not respond to the current pharmacological treatments and there may also be drug side effects. This study aims to determine the efficacy and safety of two herbal medicine products, including Rosa canina L. (RC) and a polyherbal formulation (PHF) syrups on the clinical manifestations of ADHD in children and adolescents.Methods: Ninety ADHD patients based on DSM-5 diagnostic criteria will be randomly assigned equally to three groups: (1) RC syrup + methylphenidate (MP); (2) PHF syrup + MP; (3) placebo + MP according to the inclusion criteria (30 subjects in each group). The syrups dosage is 5 cc every 8 hours and MP has a stabilized dose for 8 weeks during the study. Moreover, Conner’s questionnaires will be completed by the teacher and parents before the intervention and then every 4 weeks. Also, the child symptom inventory-fourth edition (CSI-4) and temperament questionnaires will be completed before the intervention and every four weeks until two months.Discussion: This trial is the first experiment to determine the effects of RC and PHF syrups on the clinical manifestations of ADHD in children and adolescents. Our findings provide new insight into the effect of these herbal products on the clinical manifestations of ADHD.Trial registration: The trial was registered at https://en.irct.ir/ (Registration number: IRCT20190923044855N1). Registration date: 2020-01-14.

scholarly journals Attention deficit hyperactivity disorder in children and adolescents

2013 ◽  
Vol 19 (3) ◽  
pp. 5
Author(s):  
A J Flisher ◽  
S Hawkridge
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Childhood And Adolescence ◽  
Hyperactivity Disorder

Attention deficit hyperactivity disorder (ADHD), although commonest in childhood and adolescence, can be diagnosed across the age span.

scholarly journals Behavioral and Electrophysiological Correlates of Performance Monitoring and Development in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

2020 ◽  
Vol 10 (2) ◽  
pp. 79 ◽  
Author(s):  
Yanni Liu ◽  
Gregory L. Hanna ◽  
Barbara S. Hanna ◽  
Haley E. Rough ◽  
Paul D. Arnold ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Child Behavior Checklist ◽  
Performance Monitoring ◽  
Longitudinal Design ◽  
Flanker Task ◽  
Developmental Trajectory ◽  
Time Variability ◽  
Hyperactivity Disorder

The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) involves deficits in performance monitoring and adaptive adjustments. Yet, the developmental trajectory and underlying neural correlates of performance monitoring deficits in youth with ADHD remain poorly understood. To address the gap, this study recruited 77 children and adolescents with ADHD and 77 age- and gender-matched healthy controls (HC), ages 8–18 years, who performed an arrow flanker task during electroencephalogram recording. Compared to HC, participants with ADHD responded more slowly and showed larger reaction time variability (RTV) and reduced post-error slowing; they also exhibited reduced error-related negativity (ERN) and error positivity effects, and reduced N2 and P3 congruency effects. Age effects were observed across groups: with increasing age, participants responded faster, with less variability, and with increased post-error slowing. They also exhibited increased ERN effects and increased N2 and P3 congruency effects. Increased RTV and reduced P3 amplitude in incongruent trials were associated with increased ADHD Problems Scale scores on the Child Behavior Checklist across groups. The altered behavioral and ERP responses in ADHD are consistent with the pattern associated with younger age across groups. Further research with a longitudinal design may determine specific aspects of developmental alteration and deficits in ADHD during performance monitoring.

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