The effect of timing of breast cancer surgery during the menstrual cycle phase on the axillary lymph node, estrogen receptor, progesterone receptor and c-erb B2

2020 ◽  
Author(s):  
Berrin Papila Kundaktepe Specialist ◽  
Sinem Durmus ◽  
Cigdem Papila ◽  
Mehmet Velidedeoglu ◽  
Remise Gelisgen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Menstrual Cycle ◽  
Progesterone Receptor ◽  
Luteal Phase ◽  
Breast Cancer Surgery ◽  
Cycle Phase ◽  
Axillary Lymph ◽  
Menstrual Cycle Phase ◽  
Erbb2 Gene

Abstract Background: Estrogen receptor (ER) and progesterone receptor (PR) positivity and c-erbB2 gene expression levels are important in determining breast cancer (BC) development and aggression. Although the importance of hormonal factors in tumor cell proliferation, migration and differentiation is increasing, it needs more evidence. The effect of BC surgery timing during the menstrual cycle on prognosis remains controversial. In order to clarify this hypothesis, we aimed to determine the importance of adjusting the timing of surgery according to the menstrual cycle by examining the relationship between ER, PR, c-erbB2 gene and the menstrual cycle phase in patients with premenopausal BC.Method: Our study was designed retrospectively. 50 patients with premenopausal BC who were operated were included in the study.Results: Our results showed that the patients in the luteal phase had higher ER positivity, PR positivity and c-erbB2 negativity, and the number of metastatic axillary lymph nodes was lower than the patients in follicular phase. Conclusion: BC surgery during the luteal phase in pre-menopausal women is associated with a better clinical outcome. Although larger-scale studies are needed, our results suggest that better results can be achieved by performing surgery in luteal phase in BC patients during premenopausal period.

scholarly journals Menstrual Cycle and Surgical Treatment of Breast Cancer: Findings From the NCCTG N9431 Study

2009 ◽  
Vol 27 (22) ◽  
pp. 3620-3626 ◽  
Author(s):  
Clive S. Grant ◽  
James N. Ingle ◽  
Vera J. Suman ◽  
Daniel A. Dumesic ◽  
D. Lawrence Wickerham ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Adjuvant Radiation ◽  
Menstrual Phase ◽  
Menstrual Cycle Phase ◽  
Hormone Levels ◽  
Menstrual History

Purpose For nearly two decades, multiple retrospective reports, small prospective studies, and meta-analyses have arrived at conflicting results regarding the value of timing surgical intervention for breast cancer on the basis of menstrual cycle phase. We present the results of a multi–cooperative group, prospective, observational trial of menstrual cycle phase and outcome after breast cancer surgery, led by the North Central Cancer Treatment Group (NCCTG) in collaboration with the National Surgical Adjuvant Breast and Bowel Project (NSABP) and the International Breast Cancer Study Group (IBCSG). Patients and Methods Premenopausal women age 18 to 55 years, who were interviewed for menstrual history and who were surgically treated for stages I to II breast cancer, had serum drawn within 1 day of surgery for estradiol, progesterone, and luteinizing hormone levels. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. Disease-free survival (DFS) and overall survival (OS) rates were determined by Kaplan-Meier method and were compared by using the log-rank test and Cox proportional hazard modeling. Results Of 1,118 women initially enrolled, 834 women comprised the study cohort: 230 (28%) in luteal phase; 363 (44%) in follicular phase; and 241 grouped as other. During a median follow-up of 6.6 years, and in analysis that accounted for nodal disease, estrogen receptor status, adjuvant radiation therapy or chemotherapy, neither DFS nor OS differed with respect to menstrual phase. The 5-year DFS rates were 82.7%, 82.1%, and 79.2% for follicular, luteal, or other phases, respectively. Corresponding OS survival rates were 91.9%, 92.2%, and 91.8%, respectively. Conclusion When menstrual cycle phases were strictly defined, neither DFS nor OS differed between women who underwent surgery during the follicular phase versus the luteal phase. Nearly 30% of the patients did not meet criteria for either follicular- or luteal-phase categories.

scholarly journals Timing of breast cancer surgery in relation to menstrual cycle phase: no effect on 3-year prognosis: The ITS Study

2007 ◽  
Vol 98 (1) ◽  
pp. 39-44 ◽  
Author(s):  
H Thorpe ◽  
S R Brown ◽  
J R Sainsbury ◽  
T J Perren ◽  
V Hiley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Cycle Phase ◽  
Menstrual Cycle Phase

Menstrual cycle could affect Ki67 expression in estrogen receptor-positive breast cancer patients

2015 ◽  
Vol 68 (10) ◽  
pp. 825-829 ◽  
Author(s):  
Yoshiya Horimoto ◽  
Atsushi Arakawa ◽  
Masahiko Tanabe ◽  
Keiji Kuroda ◽  
Joe Matsuoka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Expression Level ◽  
Breast Cancer Cell Lines ◽  
Cycle Phase ◽  
Ki67 Expression ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer

BackgroundKi67 is a potent prognostic marker for determining systemic treatment of patients with hormone receptor-positive breast cancer. However, evaluation of Ki67 expression can be difficult, due mostly to its heterogeneity. The Ki67 expression level, which indicates that a cell is undergoing division (cell cycle), rises when proliferation activity increases. Thus, Ki67 expression might be affected by hormonal stimuli. We hypothesised that Ki67 expression level might change during the menstrual cycle. We examined pairs of biopsy and surgical specimens from individual patients to evaluate this hypothesis.MethodsFirst, the effects of estradiol on Ki67 expression in breast cancer cell lines were examined employing immunocytochemistry and Western blotting. Next, differences in Ki67 expression between biopsy and surgical specimens from 131 patients with estrogen receptor-positive tumours were retrospectively examined.ResultsIn vitro experiments showed Ki67 expression in estrogen receptor-positive cancer cells to be dependent on estradiol stimulation. Ki67 expression was higher in biopsy samples collected in the luteal phase than in those from other phases. When biopsy and surgical samples were obtained at different times during the menstrual cycle in the same individual, there were differences in Ki67 expression between these samples. Those collected in the luteal phase showed higher Ki67 expression than samples obtained during other phases (p<0.01).ConclusionsKi67 expression varied in the same patients according to menstrual cycle phase. Our results suggest that Ki67 expression in estrogen receptor-positive breast cancer should be carefully assessed bearing in mind the patient's menstrual cycle, since the interpretation of expression could affect treatment decisions.

Surgical procedures, menstrual cycle phase, and prognosis in operable breast cancer

The Lancet ◽  
1991 ◽  
Vol 338 (8770) ◽  
pp. 815-816 ◽  
Author(s):  
R.A. Badwe ◽  
I.S. Fentiman ◽  
Z. Saad ◽  
A. Bentley ◽  
M.A. Richards ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Surgical Procedures ◽  
Operable Breast Cancer ◽  
Cycle Phase ◽  
Menstrual Cycle Phase

scholarly journals PSYCHOPHYSIOLOGICAL CHARACTERISTICS OF WOMEN IN DEPENDENCE ON THE OVARIOHORMONAL CYCLE PHASE AND PROGESTERONE ACTIVITY (PART 2)

2013 ◽  
Vol 12 (2) ◽  
pp. 257-265
Author(s):  
K. B. Muravlyova ◽  
O. I. Kuzminova ◽  
S. I. Petrova ◽  
M. V. Skoraya ◽  
O. M. Bazanova
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Peak Frequency ◽  
Follicular Phase ◽  
Progesterone Level ◽  
Cycle Phase ◽  
Alpha Band ◽  
Menstrual Cycle Phase ◽  
Subject Design ◽  
Alpha Peak

With the aim to identify the effects of menstrual cycle phase on the alpha EEG characteristics the 78 women aged 18–27 years were studied in a within-subject design Half the subjects began investigation at their follicular phase and half at their luteal phase (LP). The alpha peak frequency, alpha band width and power inalpha-2 range are highest, but power in alpha 1 and activation are lowest in LP that is associated with the highest saliva progesterone level.

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