Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

Abstract Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults.Methods: We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone mineral density reference values in Singaporean adults and comparison for osteoporosis establishment – The Yishun Study

10.21203/rs.3.rs-37206/v4 ◽

2020 ◽

Author(s):

Kexun Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥ 21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm2 in women, and 1.041±0.098g/cm2 for men. Peak whole-body BMD was 1.193±0.93g/cm2 in women at, and 1.224±0.112g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-020-03646-y ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 1

Author(s):

Kexun Kenneth Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ≥21 years. A total of 542 participants were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093 ± 0.168 g/cm2 in women, and 1.041 ± 0.098 g/cm2 for men. Peak whole-body BMD was 1.193 ± 0.93 g/cm2 in women at, and 1.224 ± 0.112 g/cm2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5–163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment – The Yishun Study

10.21203/rs.3.rs-37206/v2 ◽

2020 ◽

Author(s):

Kexun Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adultsMethods: We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.090±0.168g.cm-2 in women, and 1.041±0.098g.cm-2 for men. Peak whole body BMD was 1.193±0.93g.cm-2 in women at, and 1.224±0.112g.cm-2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Comparing diagnosis using TDXA and TSG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone mineral density reference values in Singaporean adults and comparison for osteoporosis establishment – The Yishun Study

10.21203/rs.3.rs-37206/v3 ◽

2020 ◽

Author(s):

Kexun Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adults. Methods We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged [[EQUATION]] 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T-scores (denoted by T SG ) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (T DXA ), NHANES database (T NHANES ), and China (T CHN ), and the differences in prevalence compared. We then compared the concordance between T SG and T DXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO). Results Peak lumbar spine BMD was 1.093±0.168g/cm 2 in women, and 1.041±0.098g/cm 2 for men. Peak whole-body BMD was 1.193±0.93g/cm 2 in women at, and 1.224±0.112g/cm 2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in postmenopausal women, and 0.7% in men after 50 years of age. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from T DXA , T NHANES , and T CHN . Comparing diagnosis using T DXA and T SG cut-off values, 28 versus 15 women were diagnosed as osteoporotic respectively. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Bone Mineral Density Reference Values and Prevalence of Osteoporosis in Singaporean Adults – The Yishun Study

10.21203/rs.3.rs-37206/v1 ◽

2020 ◽

Author(s):

Kexun Chen ◽

Shiou-Liang Wee ◽

Benedict Wei Jun Pang ◽

Lay Khoon Lau ◽

Khalid Abdul Jabbar ◽

...

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Reference Values ◽

World Health ◽

Whole Body ◽

Kappa Statistics ◽

Mineral Density ◽

Percentage Difference ◽

Prevalence Of Osteoporosis

Abstract Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adultsMethods: We carried out a population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.090±0.168g.cm-2 in women, and 1.041±0.098g.cm-2 for men. Peak whole body BMD was 1.193±0.93g.cm-2 in women at, and 1.224±0.112g.cm-2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in women, and 0.7% in men. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Among the 28 women who were diagnosed as osteoporotic by TDXA, 16.5% only had osteopenia according to TSG. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.

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Estimation of lumbar spine bone mineral density by dual-energy X-ray absorptiometry: standard anteroposterior scansvssub-regional analyses of whole-body scans

British Journal of Radiology ◽

10.1259/bjr/22307093 ◽

2008 ◽

Vol 81 (968) ◽

pp. 637-642 ◽

Cited By ~ 7

Author(s):

M BOYANOV

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Dual Energy ◽

Spine Bone Mineral Density ◽

Whole Body ◽

Mineral Density ◽

X Ray ◽

Regional Analyses

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Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

Sao Paulo Medical Journal ◽

10.1590/s1516-31802009000500006 ◽

2009 ◽

Vol 127 (5) ◽

pp. 278-282 ◽

Cited By ~ 14

Author(s):

Maria Eugênia Farias Almeida Motta ◽

Maria Eduarda Nóbrega de Faria ◽

Gisélia Alves Pontes da Silva

Keyword(s):

Bone Mineral Density ◽

Celiac Disease ◽

Lumbar Spine ◽

Bone Mineral ◽

Gluten Free Diet ◽

Whole Body ◽

Chronological Age ◽

Gluten Free ◽

Mineral Density ◽

Low Bone Mineral Density

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING: Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira. METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm²) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet. RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION: Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.

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Prevalence of Osteoporosis in Male Patients with Chronic Obstructive Pulmonary Disease

Medicine Today ◽

10.3329/medtoday.v30i1.35554 ◽

2018 ◽

Vol 30 (1) ◽

pp. 1-4

Author(s):

Mohammad Zabed Jillul Bari ◽

Md Ismail Patwary ◽

Md Delwar Hossain ◽

Azizul Qadar Md Abdul Hye ◽

Syed Mujibur Rahman

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Femoral Neck ◽

Bone Mineral ◽

Oral Steroid ◽

Mineral Density ◽

Normal Bone ◽

Normal Bone Mineral Density ◽

Male Patients ◽

Prevalence Of Osteoporosis

Osteoporosis is one of the systemic features of COPD. Aims and objective is to determine the prevalence of osteoporosis in male COPD. In a cross-sectional study, we conducted dual-energy X-ray absorptiometry bone mineral density scans of the femoral neck and lumbar spine and collected data on smoking, duration of COPD, inhaled and oral corticosteroid treatment and staging by pulmonary function tests. We included 60 male patients with COPD, the mean age was 62.4 ± 8.1 years, smoking was 36.8 ± 17.2 smoking-pack year, duration of COPD was 5.4 ± 3.3 years, GOLD stage-III (56.7%) stage-IV (38.3%) and stage-II (5.0%), use of oral steroid (11.7%) inhaled steroid (63.3%) and none (25.0%). Normal bone mineral density was in 6 (10.0%), osteopenia in 24 (40.0%) and osteoporosis in 30 (50%) patients in femoral neck; whereas normal bone mineral density was in 4 (6.7%), osteopenia in 17 (28.3%) and osteoporosis in 39 (65.0%) patients in lumbar spine. Osteoporosis is highly prevalent in male COPD patients in both femoral neck and lumbar spine.Medicine Today 2018 Vol.30(1): 1-4

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