Trawl impacts on the relative status of biotic communities of seabed sedimentary habitats in 24 regions worldwide

Bottom trawling is widespread globally and impacts seabed habitats. However, risks from trawling remain unquantified at large scales in most regions. We address these issues by synthesizing evidence on the impacts of different trawl-gear types, seabed recovery rates, and spatial distributions of trawling intensity in a quantitative indicator of biotic status (relative amount of pretrawling biota) for sedimentary habitats, where most bottom-trawling occurs, in 24 regions worldwide. Regional average status relative to an untrawled state (=1) was high (>0.9) in 15 regions, but <0.7 in three (European) regions and only 0.25 in the Adriatic Sea. Across all regions, 66% of seabed area was not trawled (status = 1), 1.5% was depleted (status = 0), and 93% had status > 0.8. These assessments are first order, based on parameters estimated with uncertainty from meta-analyses; we recommend regional analyses to refine parameters for local specificity. Nevertheless, our results are sufficiently robust to highlight regions needing more effective management to reduce exploitation and improve stock sustainability and seabed environmental status—while also showing seabed status was high (>0.95) in regions where catches of trawled fish stocks meet accepted benchmarks for sustainable exploitation, demonstrating that environmental benefits accrue from effective fisheries management. Furthermore, regional seabed status was related to the proportional area swept by trawling, enabling preliminary predictions of regional status when only the total amount of trawling is known. This research advances seascape-scale understanding of trawl impacts in regions around the world, enables quantitative assessment of sustainability risks, and facilitates implementation of an ecosystem approach to trawl fisheries management globally.

Global diffusion of three road safety policies, 1964–2015

Global convergence of public policies has been regarded as a defining feature of the late twentieth century. This study explores the generalizability of this thesis for three road safety measures: (i) road safety agencies; (ii) child restraint laws; and (iii) mandatory use of daytime running lights. This study analyzes cross-national longitudinal data using survival analysis for the years 1964–2015 in 181 countries. The first main finding is that only child restraint laws have globally converged; in contrast, the other two policies exhibit a fractured global convergence process, likely as the result of competing international and national forces. This finding may reflect the lack of necessary conditions, at the regional and national levels, required to accelerate the spread of policies globally, adding further nuance to the global convergence thesis. A second finding is that mechanisms of policy adoption, such as imitation/learning and competition, rather than coercion, explain more consistently global and regional convergence outcomes in the road safety realm. This finding reinforces the idea of specific elective affinities, when explaining why the diffusion of policies may or not result in convergence. Lastly, by recognizing fractured convergence processes, these results call for revisiting the global convergence thesis and reintegrating more consistently regional analyses into policy diffusion and convergence studies.

Magnetic resonance T1w/T2w ratio and voxel-based morphometry in multiple system atrophy

Diagnosis of multiple system atrophy (MSA) may be improved by using multimodal imaging approaches. We investigated the use of T1-weighted/T2-weighted (T1w/T2w) images ratio combined with voxel-based morphometry to evaluate brain tissue integrity in MSA compared to Parkinson’s disease (PD) and healthy controls (HC). Twenty-six patients with MSA, 43 patients with PD and 56 HC were enrolled. Whole brain voxel-based and local regional analyses were performed to evaluate gray and white matter (GM and WM) tissue integrity and mean regional values were used for patients classification using logistic regression. Increased mean regional values of T1w/T2w in bilateral putamen were detected in MSA-P compared to PD and HC. The combined use of regional GM and T1w/T2w values in the right and left putamen showed the highest accuracy in discriminating MSA-P from PD and good accuracy in discriminating MSA from PD and HC. A good accuracy was also found in discriminating MSA from PD and HC by either combining regional GM and T1w/T2w values in the cerebellum or regional WM and T1w/T2w in the cerebellum and brainstem. The T1w/T2w image ratio alone or combined with validated MRI parameters can be further considered as a potential candidate biomarker for differential diagnosis of MSA.

Examining Diffusion and Convergence Processes of Three Road Safety Policies, 1964-2015

Global convergence of public policies has been regarded as a defining feature of the late twentieth century. This study explores the generalizability of this thesis for three road safety measures: i) road safety agencies; ii) child restraint laws; and iii) mandatory use of daytime running lights. We analyze cross-national longitudinal data using survival analysis for the years 1964-2015 in 181 countries. Our first main finding is that only child restraint laws have globally converged; in contrast, the other two policies exhibit a fractured global convergence process, likely as the result of competing international and national forces. This finding may reflect the lack of necessary conditions, at the regional and national levels, required to accelerate the spread of policies globally, adding further nuance to the global convergence thesis. A second finding is that mechanisms of policy adoption, such as imitation/learning and competition, rather than coercion, explain more consistently global and regional convergence outcomes in the road safety realm. This finding reinforces the idea of specific elective affinities, when explaining why the diffusion of policies may or not result in convergence. Lastly, by recognizing fractured convergence processes, our results call for revisiting the global convergence thesis and reintegrating more consistently regional analyses into policy diffusion and convergence studies.

Magnetic resonance T1w/T2w ratio in multiple system atrophy: A combined study with voxel-based morphometry

Diagnosis of multiple system atrophy (MSA) may be improved by using multimodal imaging approaches. We investigated the use of T1-weighted/T2-weighted (T1w/T2w) images ratio combined with voxel-based morphometry to evaluate brain tissue integrity in MSA compared to Parkinson’s disease (PD) and healthy controls (HC). Twenty-six patients with MSA, 43 patients with PD and 56 HC were enrolled. Whole brain voxel-based and local regional analyses were performed to evaluate gray and white matter (GM and WM) tissue integrity and mean regional values were used for patients classification using logistic regression. Increased mean regional values of T1w/T2w in bilateral putamen were detected in MSA-P compared to PD and HC. The combined use of regional GM and T1w/T2w values in the right and left putamen showed the highest accuracy in discriminating MSA-P from PD and good accuracy in discriminating MSA from PD and HC. A good accuracy was also found in discriminating MSA from PD and HC by either combining regional GM and T1w/T2w values in the cerebellum or regional WM and T1w/T2w in the cerebellum and brainstem. The T1w/T2w image ratio alone or combined with validated MRI parameters can be further considered as a potential candidate biomarker for differential diagnosis of MSA.

Methylome-wide change associated with response to electroconvulsive therapy in depressed patients

Electroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment considered to be effective in treating severe and pharmacotherapy-resistant forms of depression. Recent studies have suggested that epigenetic mechanisms can mediate treatment response and investigations about the relationship between the effects of ECT and DNA methylation have so far largely taken candidate approaches. In the present study, we examined the effects of ECT on the methylome associated with response in depressed patients (n = 34), testing for differentially methylated CpG sites before the first and after the last ECT treatment. We identified one differentially methylated CpG site associated with the effect of ECT response (defined as >50% decrease in Hamilton Depression Rating Scale score, HDRS), TNKS (q < 0.05; p = 7.15 × 10−8). When defining response continuously (ΔHDRS), the top suggestive differentially methylated CpG site was in FKBP5 (p = 3.94 × 10−7). Regional analyses identified two differentially methylated regions on chromosomes 8 (Šídák’s p = 0.0031) and 20 (Šídák’s p = 4.2 × 10−5) associated with ΔHDRS. Functional pathway analysis did not identify any significant pathways. A confirmatory look at candidates previously proposed to be involved in ECT mechanisms found CpG sites associated with response only at the nominally significant level (p < 0.05). Despite the limited sample size, the present study was able to identify epigenetic change associated with ECT response suggesting that this approach, especially when involving larger samples, has the potential to inform the study of mechanisms involved in ECT and severe and treatment-resistant depression.

Hydroclimatic Variability and Land Cover Transformations in the Central Italian Alps

Extreme streamflow nonstationarity has probably attracted more attention than mean streamflow nonstationarity in the assessment of the impacts of climate change on the water cycle. Nonetheless, a significant decrease in mean streamflow could lead to conditions of scarcity of freshwater in the long-term period, seriously compromising the sustainability of the demand for civil, agricultural, and industrial uses. Regional analyses are useful to better characterize an area’s nonstationarity, since a clear trend at a global scale has not been detected yet. In this article, long-term and high-quality series of streamflow discharges observed in five rivers in the Central Italian Alps, including two multicentury series and two new precipitation and streamflow series not analyzed before, are investigated to statistically characterize individual trends of mean annual runoff volumes. Nonparametric pooled statistics are also introduced to assess the regional trend. Additional climatic and nonclimatic factors, namely, precipitation trends and land cover transformations, have also been considered as potential change drivers. Unlike precipitation, runoff volumes show a marked and statistically significant decrease of −1.45 mm/year, which appears to be homogeneous in the region. The land cover transformation analysis presented here revealed extensive woodland expansions of 510 km2 in 2018 out of the 2650 km2 area measured in 1954, representing 38% of the area investigated in this study: this anthropic driver of enhanced hydrologic losses can be recognized as an additional likely cause for the regional runoff volume decrease.

Observed snow depth trends in the European Alps: 1971 to 2019

The European Alps stretch over a range of climate zones which affect the spatial distribution of snow. Previous analyses of station observations of snow were confined to regional analyses. Here, we present an Alpine-wide analysis of snow depth from six Alpine countries – Austria, France, Germany, Italy, Slovenia, and Switzerland – including altogether more than 2000 stations of which more than 800 were used for the trend assessment. Using a principal component analysis and k-means clustering, we identified five main modes of variability and five regions which match the climatic forcing zones: north and high Alpine, north-east, north-west, south-east, and south and high Alpine. Linear trends of monthly mean snow depth between 1971 and 2019 showed decreases in snow depth for most stations from November to May. The average trend among all stations for seasonal (November to May) mean snow depth was −8.4 % per decade, for seasonal maximum snow depth −5.6 % per decade, and for seasonal snow cover duration −5.6 % per decade. Stronger and more significant trends were observed for periods and elevations where the transition from snow to snow-free occurs, which is consistent with an enhanced albedo feedback. Additionally, regional trends differed substantially at the same elevation, which challenges the notion of generalizing results from one region to another or to the whole Alps. This study presents an analysis of station snow depth series with the most comprehensive spatial coverage in the European Alps to date.