Aplastic Crisis Induced by Human Parvovirus B19 Infection in a Previously Healthy Adult Male

Background: Human parvovirus B19 (B19 V) induced aplastic crisis is very rare and in this paper, we describe a healthy adult male suddenly developed acute aplastic crisis induced by B19 V was found to have hereditary spherocytosis (HS).Case presentation: A 31-year-old male presented with fever, general fatigue and dizziness. The complete blood counts showed severe anemia. Folate levels, glucose-6-phosphate dehydrogenase levels, the direct Coombs' test and osmotic fragility tests were all normal. And B19 V infection was proven both by the detection of B19 V DNA using PCR and the presence of B19 V IgM by serology and the patient improved following six units of packed red blood cells and antiviral treatment.Conclusions: This is the first report to describe a case with B19 V, EBV and CMV co-infection diagnosed in a patient with HS in China and DNA test of B19 V is recommended in acute aplastic crisis diseases.