The Allele Frequency Variation of Autosomal 19 Short Tandem Repeat (STR) Loci in Drug Abuser: A Pilot Study
Abstract Backgrounds: Substance use disorders (SUDs) refers to drug abuse of 10 separate classes impacting seriously mental health.Objective: This study aims to explore the genetic polymorphism of the 19 short tandem repeat (STR) loci (D19S433, D5S818, D21S11, D18S51, D6S1043, D3S1358, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX, Penta E, TH01, D12S391, D2S1338, and FGA) and the risk genetic factors of substance use disorders(SUDs).Methods: The capillary electrophoresis was applied to analyze 19 STR loci in 156 drug abusers. The data of 6,134 healthy people in a previous study were applied to contrast as the control group. The differences in the frequency of the gene were analyzed by Chi-square test. Results: The gene distributions of 19 STR in drug addicts were consistent with hereditary rules. The frequency of vWA, FGA, Penta E was significantly different between the drug abuser and the control group (P<0.05).Conclusion: The 19 STR loci might provide highly informative polymorphic data for addicted genetic studies. Furthermore, there might be a predisposing gene for the drug abuser.
