scholarly journals Invasion of pterygoid plates; an indicator for regional lymph node failure in maxillary sinus cancer

2020 ◽  
Author(s):  
Yasuo Kosugi ◽  
Terufumi Kawamoto ◽  
Masaki Oshima ◽  
Mitsuhisa Fujimaki ◽  
Shinichi Ohba ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Maxillary Sinus ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intraarterial Chemotherapy ◽  
Node Failure ◽  
Long Term Treatment ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Abstract Background: The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of regional lymph node failure, and to reveal the clinical and anatomical predictive factors for metastasis.Methods: We retrospectively evaluated 55 consecutive patients with locally advanced squamous cell carcinoma of the maxillary sinus who were treated with external radiotherapy and superselective intraarterial chemotherapy. Elective nodal irradiation (ENI) was performed only in the clinical node-positive (cN+) cases and not in the clinical node-negative (cN0) cases.Results: Thirty-eight patients were cN0, and 17 were cN+ at diagnosis. Regional lymph node metastases occurred in 7 of 38 patients with cN0, and 2 of 17 with cN+ during the median follow-up period of 36 months. There were more cases of high-grade (3 or 4) late adverse events in the ENI group than in the non-ENI group (13% vs. 41%, respectively; p = 0.03). In cN0 cases without ENI, invasion of the pterygoid plates (57% vs. 90%; p < 0.01) and oral cavity (35% vs. 92%, with invasion vs without invasion, respectively; p = 0.02) was significantly correlated with a low 5-year regional recurrence-free rate.Conclusions: Patients with MCS and invasion of the pterygoid plates and oral cavity can be considered appropriate candidates for ENI.

scholarly journals Invasion of the pterygoid plates: an indicator for regional lymph node failure in maxillary sinus cancer

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yasuo Kosugi ◽  
Terufumi Kawamoto ◽  
Masaki Oshima ◽  
Mitsuhisa Fujimaki ◽  
Shinichi Ohba ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Maxillary Sinus ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intraarterial Chemotherapy ◽  
Node Failure ◽  
Long Term Treatment ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Abstract Background The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of regional lymph node failure, and to reveal the clinical and anatomical predictive factors for metastasis. Methods We retrospectively evaluated 55 consecutive patients with locally advanced squamous cell carcinoma of the maxillary sinus who were treated with external radiotherapy and superselective intraarterial chemotherapy. Elective nodal irradiation (ENI) was performed only in the clinical node-positive (cN+) cases and not in the clinical node-negative (cN0) cases. Results: Thirty-eight patients were cN0, and 17 were cN+ at diagnosis. Regional lymph node metastases occurred in 7 of 38 patients with cN0, and 2 of 17 with cN+ during the median follow-up period of 36 months. There were more cases of high-grade (3 or 4) late adverse events in the ENI group than in the non-ENI group (13% vs. 41%, respectively; p = 0.03). In cN0 cases without ENI, invasion of the pterygoid plates (57% vs. 90%; p < 0.01) and oral cavity (35% vs. 92%, with invasion vs without invasion, respectively; p = 0.02) was significantly correlated with a low 5-year regional recurrence-free rate. Conclusions Patients with MCS and invasion of the pterygoid plates and oral cavity can be considered appropriate candidates for ENI.

scholarly journals Invasion of Pterygoid Plates; an Indicator for Regional Lymph Node Failure in Maxillary Sinus Cancer

2020 ◽  
Author(s):  
Yasuo Kosugi ◽  
Terufumi Kawamoto ◽  
Masaki Oshima ◽  
Mitsuhisa Fujimaki ◽  
Shinichi Ohba ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Maxillary Sinus ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intraarterial Chemotherapy ◽  
Node Failure ◽  
Long Term Treatment ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Abstract Purpose: The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of regional lymph node failure, and to reveal the clinical and anatomical predictive factors for metastasis. Methods: We retrospectively evaluated 55 consecutive patients with locally advanced squamous cell carcinoma of the maxillary sinus who were treated with external radiotherapy and superselective intraarterial chemotherapy. Elective nodal irradiation (ENI) was performed only in the clinical node-positive (cN+) cases and not in the clinical node-negative (cN0) cases. Results: Thirty-eight patients were cN0, and 17 were cN+ at diagnosis. Regional lymph node metastases occurred in 7 of 38 patients with cN0, and 2 of 17 with cN+ during the median follow-up period of 36 months. There were more cases of high-grade (3 or 4) late adverse events in the ENI group than in the non-ENI group (13% vs. 41%, respectively; p = 0.03). In cN0 cases without ENI, invasion of the pterygoid plates (57% vs. 90%; p < 0.01) and oral cavity (35% vs. 92%; p = 0.02) was significantly correlated with a low 5-year regional recurrence-free rate. Conclusions: Patients with MCS and invasion of the pterygoid plates and oral cavity can be considered appropriate candidates for ENI.

scholarly journals Invasion of pterygoid plates; an indicator for regional lymph node failure in maxillary sinus cancer

2020 ◽  
Author(s):  
Yasuo Kosugi ◽  
Terufumi Kawamoto ◽  
Masaki Oshima ◽  
Mitsuhisa Fujimaki ◽  
Shinichi Ohba ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Maxillary Sinus ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intraarterial Chemotherapy ◽  
Node Failure ◽  
Long Term Treatment ◽  
Maxillary Sinus Cancer ◽  
Sinus Cancer

Abstract Purpose: The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of regional lymph node failure, and to reveal the clinical and anatomical predictive factors for metastasis. Methods: We retrospectively evaluated 55 consecutive patients with locally advanced squamous cell carcinoma of the maxillary sinus who were treated with external radiotherapy and superselective intraarterial chemotherapy. Elective nodal irradiation (ENI) was performed only in the clinical node-positive (cN+) cases and not in the clinical node-negative (cN0) cases. Results: Thirty-eight patients were cN0, and 17 were cN+ at diagnosis. Regional lymph node metastases occurred in 7 of 38 patients with cN0, and 2 of 17 with cN+ during the median follow-up period of 36 months. There were more cases of high-grade (3 or 4) late adverse events in the ENI group than in the non-ENI group (13% vs. 41%, respectively; p = 0.03). In cN0 cases without ENI, invasion of the pterygoid plates (57% vs. 90%; p < 0.01) and oral cavity (35% vs. 92%; p = 0.02) was significantly correlated with a low 5-year regional recurrence-free rate. Conclusions: Patients with MCS and invasion of the pterygoid plates and oral cavity can be considered appropriate candidates for ENI.

scholarly journals Patterns of regional lymph node failure of locally advanced hypopharyngeal  squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

2020 ◽  
Author(s):  
Dongqing Wang ◽  
Shui Yu ◽  
Limin Zhai ◽  
Jin Xu ◽  
Baosheng Li
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
First Line ◽  
Node Failure ◽  
Intensity Modulated ◽  
Level Ii ◽  
Nodal Failure ◽  
First Line Treatment

Abstract Background : To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT). Methods : We retrospectively obtained the clinicopathological characters of 123 hypopharyngeal SCC patients, and investigated the patterns of regional lymph node failure. Univariate and multivariate logistic regression were used to determine the risk factors of regional lymph node failure. Results : Forty patients (32.5% of total patients) were suffered regional lymph node failure. In these patients, the ipsilateral neck level II nodal failure account for 55.0% (22/40) followed by level III 30.0% (12/40), level VIb 15.0% (6/40), level VII 15.0% (6/40), and level IV 5.0% (2/40). In addition, 17.5% (7/40) patients suffered contralateral neck level II nodal failure and 7.5% (3/40) patients suffered level III nodal failure. The common failure levels were the II (7/46, 15.2%), III (4/46, 8.7%), VIb (4/46, 8.7%), and VII (5/46, 10.9%) for treatment by surgery. The lymph node recurrence and persistent disease at levels II (19/77, 24.7%) and III (10/77, 13.0%) remained the major cause of failure following curative intent of IMRT. The postoperative radiation significantly decreased the risk of regional lymph node failure (OR=0.082, 95% CI: 0.007–1.000, P=0.049); and the radiologic extranodal extension significantly increased the risk of regional lymph node failure (OR=11.07, 95% CI: 2.870–42.69, P<0.001). Conclusions: Whatever the treatment modality, the lymph node failure at level II and III was the most popular pattern for hypopharyngeal SCC. Moreover, for patients who underwent surgery, the nodal failure at level VIb and VII was frequent. Thus, postoperative radiation of level VIb and VII may give rise to benefit to locally advanced hypopharyngeal SCC patients.

scholarly journals Patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma after first-line treatment with surgery and/or intensity-modulated radiotherapy

2020 ◽  
Author(s):  
Dongqing Wang ◽  
Shui Yu ◽  
Limin Zhai ◽  
Jin Xu ◽  
Baosheng Li
Keyword(s):  
Lymph Node ◽  
Regional Lymph Node ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
First Line ◽  
Node Failure ◽  
Intensity Modulated ◽  
Level Ii ◽  
Nodal Failure ◽  
First Line Treatment

Abstract Background: To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy (IMRT).Methods: We retrospectively obtained the clinicopathological characters of 123 hypopharyngeal SCC patients, and investigated the patterns of regional lymph node failure. Univariate and multivariate logistic regression were used to determine the risk factors of regional lymph node failure.Results: Forty patients (32.5% of total patients) were suffered regional lymph node failure. In these patients, the ipsilateral neck level II nodal failure account for 55.0% (22/40) followed by level III 30.0% (12/40), level VIb 15.0% (6/40), level VII 15.0% (6/40), and level IV 5.0% (2/40). In addition, 17.5% (7/40) patients suffered contralateral neck level II nodal failure and 7.5% (3/40) patients suffered level III nodal failure. The common failure levels were the II (7/46, 15.2%), III (4/46, 8.7%), VIb (4/46, 8.7%), and VII (5/46, 10.9%) for treatment by surgery. The lymph node recurrence and persistent disease at levels II (19/77, 24.7%) and III (10/77, 13.0%) remained the major cause of failure following curative intent of IMRT. The postoperative radiation significantly decreased the risk of regional lymph node failure (OR=0.082, 95% CI: 0.007–1.000, P=0.049); and the radiologic extranodal extension significantly increased the risk of regional lymph node failure (OR=11.07, 95% CI: 2.870–42.69, P<0.001).Conclusions: Whatever the treatment modality, the lymph node failure at level II and III was the most popular pattern for hypopharyngeal SCC. Moreover, for patients who underwent surgery, the nodal failure at level VIb and VII was frequent. Thus, postoperative radiation of level VIb and VII may give rise to benefit to locally advanced hypopharyngeal SCC patients.

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