Photonic Crystal-Based Biosensor for Detection of Human Red Blood Cells Parasitized by Plasmodium Falciparum

Abstract In this paper, a biosensors based on a two-dimensional photonic crystal (2D PhC) waveguide including a ring resonator is designed and simulated based on refractive index changes of red blood cells. The proposed biosensor structure consists of an elliptical photonic crystal ring resonator and two linear waveguides containing silicon nitride rods in a 2D rectangular lattice with circular rods. The biosensor is utilized to detect the stages of the Plasmodium falciparum cycle in red blood cells and to diagnose malaria disease. The proposed design distinguishes with high sensitivity between normal red blood cells and cells infected with Plasmodium falciparum. This biosensor is very compact, consists of gold rods in the air background and works very well at two input central wavelengths of 0.514 μm and 1.55 μm. The finite-difference time-domain (FDTD) method is used to simulate and investigate the device. The biosensor is extremely compact which is very suitable for lab-on-chip applications and exhibits higher sensitivity at both input central wavelengths compared with that of previously reported sensors.

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Photonic crystal-based biosensor for detection of human red blood cells parasitized by plasmodium falciparum

Optical and Quantum Electronics ◽

10.1007/s11082-021-03421-w ◽

2021 ◽

Vol 54 (1) ◽

Author(s):

Ali Rashidnia ◽

Hassan Pakarzadeh ◽

Mohsen Hatami ◽

Natesan Ayyanar

Keyword(s):

Plasmodium Falciparum ◽

Photonic Crystal ◽

Red Blood Cells ◽

Blood Cells ◽

Human Red Blood Cells

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Fine mapping of Plasmodium falciparum ribosomal phosphoprotein PfP0 revealed sequences with highly specific binding activity to human red blood cells

Journal of Molecular Medicine ◽

10.1007/s00109-009-0533-5 ◽

2009 ◽

Vol 88 (1) ◽

pp. 61-74 ◽

Cited By ~ 3

Author(s):

Gabriela Arevalo-Pinzon ◽

Hernando Curtidor ◽

Claudia Reyes ◽

Martha Pinto ◽

Carolina Vizcaíno ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Fine Mapping ◽

Blood Cells ◽

Specific Binding ◽

Binding Activity ◽

Human Red Blood Cells

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Plasmodium falciparum rhoptry neck protein 5 peptides bind to human red blood cells and inhibit parasite invasion

Peptides ◽

10.1016/j.peptides.2013.07.028 ◽

2014 ◽

Vol 53 ◽

pp. 210-217 ◽

Cited By ~ 5

Author(s):

Hernando Curtidor ◽

Liliana C. Patiño ◽

Gabriela Arévalo-Pinzón ◽

Magnolia Vanegas ◽

Manuel E. Patarroyo ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Blood Cells ◽

Parasite Invasion ◽

Human Red Blood Cells ◽

Rhoptry Neck Protein

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Identification of Plasmodium falciparum MSP‐1 peptides able to bind to human red blood cells

Parasite Immunology ◽

10.1046/j.1365-3024.1996.d01-15.x ◽

1996 ◽

Vol 18 (10) ◽

pp. 515-526 ◽

Cited By ~ 106

Author(s):

MAURICIO URQUIZA ◽

LUIS E. RODRIGUEZ ◽

JORGE E. SUAREZ ◽

FANNY GUZMÁN ◽

MARISOL OCAMPO ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Blood Cells ◽

Human Red Blood Cells

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The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells

Blood Cells Molecules and Diseases ◽

10.1016/j.bcmd.2004.01.004 ◽

2004 ◽

Vol 32 (3) ◽

pp. 344-348 ◽

Cited By ~ 7

Author(s):

Henry M Staines ◽

Belinda C Dee ◽

Meng-Ru Shen ◽

J.Clive Ellory

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Blood Cells ◽

Anion Channel ◽

Human Red Blood Cells

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Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions

Blood ◽

10.1182/blood.v78.3.812.812 ◽

1991 ◽

Vol 78 (3) ◽

pp. 812-819 ◽

Cited By ~ 119

Author(s):

DK Kaul ◽

EF Jr Roth ◽

RL Nagel ◽

RJ Howard ◽

SM Handunnetti

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Blood Cells ◽

Peripheral Resistance ◽

Inverse Correlation ◽

Rosette Formation ◽

Flow Conditions ◽

Human Red Blood Cells ◽

Venular Endothelium

Abstract The occurrence of rosetting of Plasmodium falciparum-infected human red blood cells (IRBC) with uninfected red blood cells (RBC) and its potential pathophysiologic consequences were investigated under flow conditions using the perfused rat mesocecum vasculature. Perfusion experiments were performed using two knobby (K+) lines of P falciparum, ie, rosetting positive (K+R+) and rosetting negative (K+R-). The infusion of K+R+ IRBC resulted in higher peripheral resistance (PRU) than K+R- IRBC (P less than .0012). Video microscopy showed that under conditions of flow, in addition to cytoadherence of K+R+ IRBC to the venular endothelium, rosette formation was also restricted to venules, especially in the areas of slow flow. Rosettes were absent in arterioles and were presumably dissociated by higher wall shear rates. The presence of rosettes in the venules must therefore reflect their rapid reformation after disruption. Cytoadherence of K+R+ IRBC was characterized by formation of focal clusters along the venular wall. In addition, large aggregates of RBC were frequently observed at venular junctions, probably as a result of interaction between flowing rosettes, free IRBC, and uninfected RBC. In contrast, the infusion of K+R+ IRBC resulted in diffuse cytoadherence of these cells exclusively to the venular endothelium but not in rosetting or large aggregate formation. The cytoadherence of K+R+ IRBC showed strong inverse correlation with the venular diameter (r = -.856, P less than .00001). Incubation of K+R+ IRBC with heparin and with monoclonal antibodies to glycoprotein IV/CD36 abolished the rosette formation and resulted in decreased PRU and microvascular blockage. These findings demonstrate that rosetting of K+R+ IRBC with uninfected RBC enhances vasocclusion, suggesting an important in vivo role for rosetting in the microvascular sequestration of P falciparum-infected RBC.

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