Case Report: Both Mother and Child With Chronic HBV Infection Were Clinically Cured After PEG-IFN Treatment
Abstract Background：Interferon is significant for chronic hepatitis B patients to get ideal treatment endpoint—functional cure, and is widely used as a first line therapy.Case presentation：We reported two cases of consanguineous patients with chronic hepatitis B. Case 1 was a 36-year-old woman with chronic hepatitis B for 13 years. Case 2 and case 1 were mother-child relationship. At the age of 2, HBsAg and HBeAg of case 2 were found to be positive during physical examination, and they received antiviral therapy together. Both mother and child were treated with Peginterferon (PEG-IFN). Based on antiviral therapy, through prolonged interferon therapy or combined with oral medication of individualized treatment, they both achieved clinical cure.Conclusion：The outcome of the two patients suggests not only the significance of individualized antiviral therapy but also a high correlation between the response to interferon antiviral therapy and genetic background.
