Mechanisms of Sex Differences in Ankylosing Spondylitis: Interleukin 2 Receptor Subunit Beta and CD3d Molecule Play an Important Role

Introduction:ankylosing spondylitis (AS) is characterized by sexual dimorphism in clinical manifestations. Our aim is to reveal the reason for gender difference in AS. Material and Methods: we used bioinformatics to analyze gene expression data of GSE73754. And verified by PCR and ELISA. Results: the pathogenic pathways leading to AS are Th1 and Th2 cell differentiation. The key gene involved in this pathway in male is interleukin 2 receptor subunit beta (IL2RB). The key genes involved in female are IL2RB and CD3d molecule (CD3D) . Both genes are immune-related genes.Conclusion: differences in key genes contribute to gender differences in AS. Male AS may require only one gene, while female AS requires two genes.