scholarly journals Decreased Serum Iron Concentration and Total Iron Binding Capacity Are Associated With Serious Crohn’s Disease

2021 ◽  
Author(s):  
Jingling Su ◽  
Yandan Ren ◽  
Lupeng Liu ◽  
Yiqun Hu ◽  
Huaxiu Shi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Stores ◽  
Patient Groups ◽  
Iron Binding Capacity ◽  
Combined Detection

Abstract Background: This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity.Methods: Eighty-four patients with Crohn’s disease (CD) and twenty-four healthy volunteers were included. The indicators related to iron stores were detected within one week after endoscopic and CT enterography examinations.Results: Patients were divided into three groups according to the CDAI scores. Serum iron levels were decreased in all patient groups (p<0.05), and the values of remission group were higher than those of moderate group (p<0.001). The total iron binding capacity （TIBC） values of the moderate group were lower than those of the controls and the other patient groups (p<0.05). None of the indicators differed significantly among the patients classified by SES-CD (p>0.05). Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. The sensitivity and specificity were 32.7% and 100%, respectively (AUC = 0.812, p<0.01).Conclusions: Decreases in serum iron and TIBC were associated with the clinical activity of CD. Combined detection of the two indicators was conducive to screening patients with serious disease.

scholarly journals Decreased Serum Iron Concentration and Total Iron Binding Capacity Are Associated With Serious Crohn’s Disease

2021 ◽  
Author(s):  
Jingling Su ◽  
Yandan Ren ◽  
Lupeng Liu ◽  
Yiqun Hu ◽  
Huaxiu Shi ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Patient Groups ◽  
Iron Binding Capacity ◽  
Combined Detection

Abstract Background This study aimed to investigate whether serum indicators related to iron stores in the body are associated with clinical and endoscopic disease severity. Methods Eighty-four patients with Crohn’s disease (CD) and twenty-four healthy volunteers were included in this retrospective study. Clinical and endoscopic severity of disease was recorded by Crohn’s disease activity index (CDAI) scores and the simple endoscopic score of Crohn’s disease (SES-CD), respectively. The indicators related to iron stores included serum iron (SI), total iron binding capacity (TIBC), ferritin, transferrin (Tf), and transferrin saturation (TSAT%). They were detected within one week after endoscopic and CT enterography examinations. Results Patients were divided into three groups according to the CDAI scores. Serum iron levels were decreased in all patient groups (p < 0.05), and the values of remission group were higher than those of moderate group (p < 0.001). The TIBC values of the moderate group were lower than those of the controls and the other patient groups (p < 0.05). The above two indicators were negatively correlated with CDAI scores (p < 0.05). None of the indicators differed significantly among the patients classified by SES-CD (p > 0.05). Underweight, decreased serum iron and TIBC were independent risk factors for moderate clinical disease. Combined detection of decreased serum iron and TIBC was helpful in differentiating severe patients. The sensitivity and specificity were 32.7% and 100%, respectively (AUC = 0.812, p < 0.01). Conclusions Decreases in serum iron and TIBC were associated with the clinical activity of CD. Combined detection of the two indicators was conducive to screening patients with serious disease.

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

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