Determining the Optimal Dose of 18F-FDG for Hodgkin lymphoma Imaging on PET/CT Camera with BGO Crystals

Abstract Purpose: We aimed to find the minimum feasible dose of fluorodeoxyglucose (18F-FDG) in positron emission tomography/computed tomography (PET/CT) of Hodgkin lymphoma patients performed on a camera with bismuth germanate (BGO) crystals.Methods: Ninety-one 18F-FDG PET/CT scans with decreasing time per bed position (2 min, 1.5 min, 1 min, 50 sec, 40 sec, 30 sec and 20 sec) were assessed to evaluate image quality. Mean administered dose was 3.0±0.1 MBq/kg and mean uptake time was 54.0±8.7 min. The series quality was subjectively marked in 1-10 scale and then ranked 1-7 based on the mean mark. Interobserver rank correlation and intraclass correlation within each series were calculated. Phantom studies were also performed to determine if reduced acquisition time can be directly translated into a reduced dose. Results: We show the longer the time of acquisition the higher the mark and rank. The interobserver agreement in ranking was 100% with kappa coefficient of 1.00 (95% CI [0.83-1.0]). The general intraclass correlation coefficient was 0.945 (95% CI [0,936-0,952]). Only the series with 2 min and 1.5 min acquisition time were appropriate for assessment (mean mark ≥7). In phantom studies there was a linear correlation between time per bed, administered activity and number of total prompts detected by a scanner. Hence, reduction of acquisition time of 25% (from 2 min to 1.5 min) could be directly translated into a 25% dose reduction (from 3.0 to 2.25 MBq/kg).Conclusions: In patients with HL, 18F-FDG dose can be reduced by up to 25% when using a BGO crystal camera, without substantial impact on image quality.

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The image quality, lesion detectability, and acquisition time of 18F-FDG total-body PET/CT in oncological patients

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-020-04823-w ◽

2020 ◽

Vol 47 (11) ◽

pp. 2507-2515 ◽

Cited By ~ 2

Author(s):

Yi-Qiu Zhang ◽

Peng-Cheng Hu ◽

Run-Ze Wu ◽

Yu-Shen Gu ◽

Shu-Guang Chen ◽

...

Keyword(s):

Image Quality ◽

Acquisition Time ◽

Lesion Detectability ◽

Oncological Patients ◽

Pet Ct ◽

18F Fdg ◽

Total Body

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The effect of reduced scan time on response assessment FDG-PET/CT imaging using Deauville score in patients with lymphoma

European Journal of Hybrid Imaging ◽

10.1186/s41824-021-00096-0 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Charlotte Hornnes ◽

Annika Loft ◽

Liselotte Højgaard ◽

Flemming Littrup Andersen

Keyword(s):

Image Quality ◽

Hodgkin Lymphoma ◽

Fdg Pet ◽

Response Assessment ◽

Acquisition Time ◽

List Mode ◽

Deauville Score ◽

Scan Time ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Purpose [18F]Fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) is used for response assessment during therapy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Clinicians report the scans visually using Deauville criteria. Improved performance in modern PET/CT scanners could allow for a reduction in scan time without compromising diagnostic image quality. Additionally, patient throughput can be increased with increasing cost-effectiveness. We investigated the effects of reducing scan time of response assessment FDG-PET/CT in HL and NHL patients on Deauville score (DS) and image quality. Methods Twenty patients diagnosed with HL/NHL referred to a response assessment FDG-PET/CT were included. PET scans were performed in list-mode with an acquisition time of 120 s per bed position(s/bp). From PET list-mode data images with full acquisition time of 120 s/bp and shorter acquisition times (90, 60, 45, and 30 s/bp) were reconstructed. All images were assessed by two specialists and assigned a DS. We estimated the possible savings when reducing scan time using a simplified model based on assumed values/costs for our hospital. Results There were no significant changes in the visually assessed DS when reducing scan time to 90 s/bp, 60 s/bp, 45 s/bp, and 30 s/bp. Image quality of 90 s/bp images were rated equal to 120 s/bp images. Coefficient of variance values for 120 s/bp and 90 s/bp images was significantly < 15%. The estimated annual savings to the hospital when reducing scan time was 8000-16,000 €/scanner. Conclusion Acquisition time can be reduced to 90 s/bp in response assessment FDG-PET/CT without compromising Deauville score or image quality. Reducing acquisition time can reduce costs to the clinic.

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