scholarly journals Can the BMI-based dose regimen be used to reduce injection activity and to obtain a constant image quality in oncological patients by 18F-FDG total-body PET/CT imaging?

2021 ◽  
Author(s):  
Jie Xiao ◽  
Haojun Yu ◽  
Xiuli Sui ◽  
Yan Hu ◽  
Yanyan Cao ◽  
...  
Keyword(s):  
Image Quality ◽  
Dose Regimen ◽  
Ct Imaging ◽  
Oncological Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Total Body

The image quality, lesion detectability, and acquisition time of 18F-FDG total-body PET/CT in oncological patients

2020 ◽  
Vol 47 (11) ◽  
pp. 2507-2515 ◽  
Author(s):  
Yi-Qiu Zhang ◽  
Peng-Cheng Hu ◽  
Run-Ze Wu ◽  
Yu-Shen Gu ◽  
Shu-Guang Chen ◽  
...  
Keyword(s):  
Image Quality ◽  
Acquisition Time ◽  
Lesion Detectability ◽  
Oncological Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Total Body

scholarly journals Can the BMI-Based Dose Regimen be Used to Reduce Injection Activity and to Obtain a Constant Image Quality in Oncological Patients by 18F-FDG Total-Body PET/CT Imaging?

2021 ◽  
Author(s):  
Jie Xiao ◽  
Haojun Yu ◽  
Xiuli Sui ◽  
Yan Hu ◽  
Cao Yanyan ◽  
...  
Keyword(s):  
Image Quality ◽  
Dose Regimen ◽  
Qualitative Assessment ◽  
Acquisition Time ◽  
Quadratic Relation ◽  
Patient Cohort ◽  
Oncological Patients ◽  
Pet Ct ◽  
Patient Size ◽  
Total Body

Abstract Purpose PET image quality is influenced by the patient size according to the current guideline. The purpose was to propose an optimized dose regimen to yield a constant image quality independent of patient size to meet the clinical needs.Methods A first patient cohort of 78 consecutives for oncological patients (59.7±13.7 years) who underwent a total-body PET/CT scan were retrospectively enrolled to develop the regimen. The patients were equally distributed in four BMI groups according to WHO criteria. The liver SNR (Signal noise ratio, SNRL) was obtained through manually drawing ROIs and normalized (SNRnorm) by the injected activity and acquisition time. And fits of SNRnorm against different patient-dependent parameters were performed to determine the best correlating parameter and fit method. A qualitative assessment on image quality was performed using a 5-point Likert scale to determine the acceptable threshold of SNRL. And thus, an optimized regimen was proposed and validated by a second patient cohort with prospectively enrolled 38 oncological patients. Results The linear fit showed SNRnorm was the strongest correlation (R2 = 0.69) with the BMI than other patient-dependent parameters. The qualitative assessment revealed a SNRL of 14.0 as a threshold to achieve a sufficient image quality. The optimized dose regimen was determined as a quadratic relation with BMI: Injected activity = 39.2 MBq/(-0.03*BMI+1.49)2. In the validation study, the SNRL no longer decreased with the increase of BMI. There was no significant difference of the image quality, the SNRL, between different BMI groups (p > 0.05). In addition, the injected activity was reduced by 75.6±2.9 %, 72.1±4.0 %, 67.1±4.4 % and 64.8±3.5 % compared to the first cohort for the four BMI groups, respectively.Conclusion The study recommended a quadratic relation between the 18F-FDG injected activity and the patient’s BMI and propose a regimen for total-body PET imaging. In the regimen, the image quality can maintain in a constant level independent of patient size and meet the clinical requirement even with a reduced injected activity.

Image quality and lesion detectability in low-dose pediatric 18F-FDG scans using total-body PET/CT

2021 ◽  
Author(s):  
Yu-Mo Zhao ◽  
Ying-He Li ◽  
Tao Chen ◽  
Wei-Guang Zhang ◽  
Lin-Hao Wang ◽  
...  
Keyword(s):  
Image Quality ◽  
Low Dose ◽  
Lesion Detectability ◽  
Pet Ct ◽  
18F Fdg ◽  
Total Body

scholarly journals Feasibility of Low-Dose 68Ga-DOTATATE With Short Acquisition Time Using Total-Body PET/CT in Patients With Neuroendocrine Tumor

2021 ◽  
Author(s):  
Jie Xiao ◽  
Haojun Yu ◽  
Hongyan Yin ◽  
Guobin Liu ◽  
Yan Hu ◽  
...  
Keyword(s):  
Image Quality ◽  
Dose Regimen ◽  
Low Dose ◽  
Signal To Noise Ratio ◽  
Subjective Evaluation ◽  
Blood Pool ◽  
Acquisition Time ◽  
Short Acquisition Time ◽  
Pet Ct ◽  
Total Body

Abstract Purpose To explore the feasibility of a low dose regimen with short acquisition time of 68Ga-DOTATATE total-body PET/CT without compromising image quality of patients with NETs. Methods Fifty-seven consecutive NETs patients who underwent 68Ga-DOTATATE total-body PET/CT, with a low dose regimen (0.8-1.2 MBq/kg) of 68Ga-DOTATATE and acquisition time of 10 min prior to any treatment, were enrolled in the present study. The PET data were split into 1 min, 2 min, 3 min, 4 min, 5 min, 8 min and 10 min reconstruction groups, referenced as R1, R2, R3, R4, R5, R8 and R10. The subjective evaluation of image quality was scored in 5-point Likert scale based on three aspects: the overall impression of the image quality, the image noise, the lesion detectability. The objective image quality was assessed by the signal-to-noise ratio of liver (SNRL), the coefficient of variation (CV), the SUVmax, SUVmean, SD of liver, mediastinal blood pool and lesion, the tumor-liver ratio (TLR), the tumor-mediastinal blood pool-ratio (TMR) of lesion. Results The sufficient subjective image quality with a score of 3.44±0.53 could be obtained at 3 min acquisition duration, with a kappa value of 0.90. In quantitative analysis, the value of SNRL is over 10 in all reconstruction groups. As the acquisition time increases, SNRL was increased and CV was decreased within 3 min, while SNRL and CV showed no significant different between R4-R10. There was no significant different in TMR and TLR of lesion between R1-R10 (all p < 0.05). Referenced as PET images of R10, 90 SSTR-positive lesions are identified, and all those lesions are found in the R1-R10 groups (100%).Conclusion The low-dose (0.8-1.2 MBq/kg) 68Ga-DOTATATE total-body PET/CT not only shortens acquisition time, but maintains a sufficient image quality for the NETs patients.

scholarly journals Total-body 18F-FDG PET Scan in Oncological Patients: How Fast could it be?

2021 ◽  
Author(s):  
Pengcheng Hu ◽  
Yiqiu Zhang ◽  
Haojun Yu ◽  
Shuguang Chen ◽  
Hui Tan ◽  
...  
Keyword(s):  
Image Quality ◽  
Phantom Study ◽  
Pet Scan ◽  
Clinical Settings ◽  
Recovery Coefficient ◽  
Clinical Images ◽  
Oncological Patients ◽  
Pet Ct ◽  
Significant Difference ◽  
Total Body

Abstract Purpose: The aim of the study was to explore a fast PET scan protocol of the total-body uEXPLORER scanner by assessing the image quality consistent to that of a conventional digital PET/CT scanner both from the phantom and clinical perspectives.Methods: The phantom study using a NEMA/IEC NU-2 body phantom was performed both on a total-body PET/CT (uEXPLORER) and a digital routine PET/CT (uMI 780), with hot sphere to background activity concentration ratio of 4:1. The contrast recovery coefficient (CRC), background variability (BV), recovery coefficient RCmax and RCmean were assessed and compared between that in uEXPLORER with the different scanning duration and reconstruction protocols and that in uMI 780 with clinical settings. The coefficient of variation (COV) of the uMI 780 with clinical settings were calculated and used as a threshold to determine the optimized scanning duration and reconstruction protocols were, which can provide a consistent image quality for the two scanners. And subsequently, the proposed protocol was validated by 30 oncological patients. Images acquired in uMI 780 with a 2-3 minute for each bed position were referred as G780. All PET raw data were reconstructed using data-cutting technique to simulate a 30s, 45s or 60s acquisition duration on uEXPLORER. The iterations were 2 and 3 for uEXPLORER, referred as G30s_3i, G45s_2i, G45s_3i, G60s_2i, and G60s_3i. A 5-point Likert scale was used in the qualitative analysis to assess the image quality. The image quality was also compared with the liver COV, the lesion target-to-background ratio (TBR), and the lesion signal-to-noise ratio (SNR).Results: In the phantom study, CRC, BV, RCmax and RCmean in uEXPLORER with different scanning duration and reconstruction iterations were compared with that in uMI 780 with clinical settings and a minor fluctuation was found among different scanning durations. COV of the uMI 780 with clinical settings was 11.6% and determined protocol with a 30-45s scanning duration and 2 or 3 iterations to provide a similar image quality.In the quantitative analysis on the clinical images, there was no significant difference between G780 and G45s_3i. All the other groups in uEXPLORER with a 45s- and above acquisition showed a significantly improved image quality than that in uMI 780 with clinical settings. Comparing the liver COV, there was no significantly difference between G780 and G30s_3i. And no significant difference in lesion TBR was identified between G780 and G45s_2i, while uEXPLORER had a better performance in lesion SNR compared to that in uMI 780 with clinical settings. Conclusions: This study demonstrated a fast PET protocol with a 30-45s acquisition in uEXPLORER with consistent image quality to that in uMI 780 with clinical settings.

scholarly journals Longitudinal [18F]FDG and [13N]NH3 PET/CT imaging of brain and spinal cord in a canine hemisection spinal cord injury model

2021 ◽  
pp. 102692
Author(s):  
Lijian Zhang ◽  
Francisco R. López-Picón ◽  
Yingqin Jia ◽  
Yao Chen ◽  
Juan Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ct Imaging ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Pet Ct ◽  
Cord Injury ◽  
18F Fdg ◽  
Brain And Spinal Cord

Total-body 18F-FDG PET/CT scan in oncology patients: how fast could it be?

2021 ◽  
Author(s):  
Pengcheng Hu ◽  
Yiqiu Zhang ◽  
Haojun Yu ◽  
Shuguang Chen ◽  
Hui Tan ◽  
...  
Keyword(s):  
Ct Scan ◽  
Fdg Pet ◽  
Oncology Patients ◽  
Pet Ct ◽  
18F Fdg ◽  
Total Body ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

scholarly journals 18F-FDG PET/CT imaging findings of multiple solitary fibrous tumor

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16743
Author(s):  
Xiaofei Liu ◽  
Wenhua Zhu ◽  
Xiaohong Zhou ◽  
Hao Yao ◽  
Jiagui Su ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fibrous Tumor ◽  
Fdg Pet Ct

scholarly journals Hibernoma: 18F FDG PET/CT Imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 569-570 ◽  
Author(s):  
Rathan M. Subramaniam ◽  
Amy C. Clayton ◽  
Dimitrios Karantanis ◽  
Douglas A. Collins
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
Sign in / Sign up

Export Citation Format

Share Document